Handbook of Systems Biology: Concepts and Insights (Hardcover)

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This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics.

Key Features

*Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines
*Includes the latest research developments in human and animal models to assist with translational research
*Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers

Table Of Contents

SECTION I: Component of biological systems
Proteomic analysis of cellular systems
The protein-coding transcriptome
ncRNAs and their targets

SECTION II: Network properties of biological systems
Probabilistic functional networks
Protein-protein inteactome networks
Gene regulatory networks
Phenotypic profiling networks
Genetic interaction networks
Chromatin networks
Drug-target networks
Graph theory properties of cellular networks

SECTION III: Dynamic and logical propoerties of biological systems
Boolean models of cellular networks
Bayesian approaches in understanding networks
Transcriptional network logic in development
Metabolic systems reconstruction
Evolution of biological networks
Systems understanding of the cell cycle
Quantitative design principles on molecular systems
Systems biology of signaling
Single cell systems dynamics
Spatial organization of cellular systems

SECTION IV: Systems and biology
Systems understanding of yeast biology
systems understandingof c.elegans development
Biological systems in Arabidopsis
Biological rhythms in development and hemeostasis
System biology of stem cells
The brain connectome

SECTION V:MULTISCALE BIOLOGICAL SYSTEMS, HEALTH AND ECOLOGY
Systems medicine
Cancer systems biology
Infectious disease and the immune system
Network perturbations and disease states
Impact of personal genomics on systems biology
Social networks, human disease, and epidemics

本書為遺傳學、分子生物學、細胞生物學、微生物學和生物醫學科學研究人員提供了進入系統生物學的入門點，以了解擴展他們工作的關鍵概念。章節組織圍繞著器官和生物體、生物過程的系統特性、細胞網絡以及系統生物學和疾病等更廣泛的主題進行討論，探討了概念的發展、當前應用和未來前景。強調了該領域的多學科性質以及系統生物學在人類生物研究中的重要性。科技作為科學進步的一個極其重要的方面，特別是在創造新領域方面，在每個章節中以“方框”的形式討論，以與相應的主題相關聯。

主要特點：

* 強調系統生物學的跨學科性，並由各個學科的領導者提供貢獻
* 包括人類和動物模型的最新研究發展，以協助轉化研究
* 將科學和計算方面的內容並列，以促進計算和生物研究人員之間的合作

目錄：

第一部分：生物系統的組成部分
細胞系統的蛋白質組學分析
蛋白質編碼轉錄組
非編碼RNA及其靶點

第二部分：生物系統的網絡特性
概率功能網絡
蛋白質相互作用網絡
基因調控網絡
表型分析網絡
基因互作網絡
染色質網絡
藥物靶點網絡
細胞網絡的圖論特性

第三部分：生物系統的動態和邏輯特性
細胞網絡的布爾模型
理解網絡的貝葉斯方法
發育中的轉錄網絡邏輯
代謝系統重建
生物網絡的演化
對細胞週期的系統理解
分子系統的定量設計原則
信號傳導的系統生物學
單個細胞系統動力學
細胞系統的空間組織

第四部分：系統和生物學
酵母生物學的系統理解
線蟲發育的系統理解
拟南芥中的生物系統
發育和體內平衡的生物節奏
幹細胞的系統生物學
大腦連接組

第五部分：多尺度生物系統、健康和生態學
系統醫學
癌症系統生物學
傳染病和免疫系統
網絡干擾和疾病狀態
個人基因組學對系統生物學的影響
社交網絡、人類疾病和流行病