Microarrays for an Integrative Genomics (Hardcover)

Description:

Functional genomics--the deconstruction of the genome to determine the biological function of genes and gene interactions--is one of the most fruitful new areas of biology. The growing use of DNA microarrays allows researchers to assess the expression of tens of thousands of genes at a time. This quantitative change has led to qualitative progress in our ability to understand regulatory processes at the cellular level.

This book provides a systematic introduction to the use of DNA microarrays as an investigative tool for functional genomics. The presentation is appropriate for readers from biology or bioinformatics. After presenting a framework for the design of microarray-driven functional genomics experiments, the book discusses the foundations for analyzing microarray data sets, genomic data-mining, the creation of standardized nomenclature and data models, clinical applications of functional genomics research, and the future of functional genomics.

Isaac S. Kohane is Director of the Children’s Hospital Informatics Program, Associate Professor of Pediatrics at Harvard Medical School, and an Attending Physician in Endocrinology at Children's Hospital, Boston.

Alvin Kho is Research Fellow in Medicine at Children's Hospital, Boston.

Atul J. Butte is a Staff Informatician in the Children's Hospital Informatics Program, an Instructor in Pediatrics at Harvard Medical School, and an Attending Physician in Endocrinology at Children's Hospital, Boston.

 

 

描述：
功能基因組學是將基因組解構以確定基因和基因相互作用的生物學功能的一個最有成果的新領域之一。DNA微陣列的廣泛應用使研究人員能夠同時評估數以萬計的基因表達。這種定量變化使我們能夠在細胞水平上更好地理解調控過程。

本書系統地介紹了DNA微陣列作為功能基因組學研究工具的使用。這本書的內容適合生物學或生物信息學的讀者。在介紹了微陣列驅動的功能基因組學實驗設計框架之後，本書討論了分析微陣列數據集的基礎知識、基因組數據挖掘、標準化命名和數據模型的建立、功能基因組學研究的臨床應用以及功能基因組學的未來。

Isaac S. Kohane是兒童醫院信息學計劃主任，哈佛醫學院兒科副教授，兒童醫院內分泌學主治醫師。

Alvin Kho是兒童醫院研究員。

Atul J. Butte是兒童醫院信息學計劃的一名工作人員，哈佛醫學院兒科講師，兒童醫院內分泌學主治醫師。