Bioinformatics in the Post-Genomic Era : Genome, Transcriptome, Proteome, and Information-Based Medicine

Jeff Augen

  • 出版商: Addison Wesley
  • 出版日期: 2004-08-27
  • 售價: $2,110
  • 貴賓價: 9.5$2,005
  • 語言: 英文
  • 頁數: 408
  • 裝訂: Paperback
  • ISBN: 0321173864
  • ISBN-13: 9780321173867
  • 相關分類: 生物資訊 Bioinformatics
  • 海外代購書籍(需單獨結帳)
    無現貨庫存(No stock available)

買這商品的人也買了...

商品描述

Table of Contents:

Preface.

1. Introduction.

Overview.

Computationally Intense Problems: A Central Theme in Modern Biology.

Building the Public Infrastructure.

The Human Genome’s Several Layers of Complexity.

Toward Personalized Medicine.

Illnesses are Polygenic.

New Science, New Infrastructure.

The Proactive Future of Information-Based Medicine.

2. Introduction to Bioinformatics.

Introduction.

The Emergence of Bioinformatics.

The Public Database Infrastructure.

Building Database Infrastructure for Bioinformatics.

Traditional Bioinformatic Tools and Algorithms.

Summary.

3. Gene Structure.

Introduction.

The Central Dogma of Molecular Biology.

The Genetic Code.

Structure and Content of the Genome.

Computational Techniques for the Identification of Genomic Features.

High-Throughput Gene Sequencing.

Summary.

4. Computational Techniques for Sequence Analysis.

Introduction.

Hidden Markov Models.

Perceptrons and Neural Networks.

Pattern Discovery, Single Nucleotide Polymorphisms, and Haplotype Identification.

Summary.

5. Transcription.

Introduction.

The Transcriptome.

Technologies for Transcriptional Profiling.

Hierarchical Clustering.

Summary.

6. Overview of the Proteome and the Protein Translation Process.

Introduction.

Ribosomal Structure and the Protein Translation Process.

Special Features of the Eukaryotic-Translation Process.

Summary.

7. Protein Structure Prediction.

Introduction.

Overview of Ab Initio and Database-Driven Approaches.

Overview of   Protein Structure.

Protein Structure Databases.

Ab Initio Structure Prediction.

Predicting Lead–Target Interactions.

Summary.

8. Medical Informatics and Information-Based Medicine.

Introduction.

The Continuous Evolution in Understanding that Leads to Genomic Medicine.

Electronic Medical Records.

Grid Computing and Medical Informatics.

Modeling and Predicting Disease.

Summary.

9. New Themes in Bioinformatics.

Introduction.

Overview of Parallel Computing and Workflow Distribution in Bioinformatics.

Workflow Computing.

High-Performance Computing and Systems Biology.

The Delineation of Metabolic Pathways.

Systems Biology.

Summary.

Further Reading.

Index.

商品描述(中文翻譯)

目錄:

前言。
1. 簡介。
- 概述。
- 現代生物學中的計算密集型問題。
- 建立公共基礎設施。
- 人類基因組的多層次複雜性。
- 迈向個性化醫學。
- 疾病是多基因的。
- 新科學,新基礎設施。
- 基於信息的醫學的主動未來。
2. 生物信息學簡介。
- 簡介。
- 生物信息學的出現。
- 公共數據庫基礎設施。
- 為生物信息學建立數據庫基礎設施。
- 傳統生物信息學工具和算法。
- 總結。
3. 基因結構。
- 簡介。
- 分子生物學的中心法則。
- 遺傳密碼。
- 基因組的結構和內容。
- 用於識別基因組特徵的計算技術。
- 高通量基因序列。
- 總結。
4. 序列分析的計算技術。
- 簡介。
- 隱馬爾可夫模型。
- 感知器和神經網絡。
- 模式發現,單核苷酸多態性和單倍型鑑定。
- 總結。
5. 轉錄。
- 簡介。
- 轉錄組。
- 轉錄分析技術。
- 階層聚類。
- 總結。