Glutathione
暫譯: 谷胱甘肽
Flohe, Leopold
- 出版商: CRC
- 出版日期: 2020-09-30
- 售價: $2,450
- 貴賓價: 9.5 折 $2,328
- 語言: 英文
- 頁數: 410
- 裝訂: Quality Paper - also called trade paper
- ISBN: 036765699X
- ISBN-13: 9780367656997
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相關主題
商品描述
This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione-S-transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets.
Key selling features:
- Summarizing the way glutathione is involved in stress responses
- Compiling the multiple ways glutathione affects inflammatory responses
- Disclosing how glutathione dampens programmed cell death such as ferroptosis
- Exploring the enigma of how enzymes accelerate glutathione-dependent processes
- Discussing how detoxification and redox regulation is mediated by glutathionylation
- Reviewing the ways glutaredoxins catalyze protein disulfide reduction
- Highlighting the medical impact of glutathione-related metabolic pathways
- Illustrating the role thiol metabolism of pathogens might play in drug discovery
商品描述(中文翻譯)
這是對於過去三十年來有關谷胱甘肽（glutathione）所有已知資訊的第一次嚴肅嘗試綜合。本書包含了谷胱甘肽生物合成的最新進展，特別強調其在適應性壓力反應中的調控。其他章節回顧了谷胱甘肽運輸系統和谷胱甘肽過氧化酶（glutathione peroxidases），以及它們在底物特異性和定位上的差異。進一步的貢獻集中於不同谷胱甘肽-S-轉移酶（glutathione-S-transferases）的多樣化角色，以及亞硝基谷胱甘肽（nitrosoglutathione）和谷胱甘肽還原酶（glutaredoxins）——一種還原酶亞家族的角色。本書最後討論了病原體中類似或同源的硫醇代謝及相關酶作為藥物靶點的潛在適用性。
主要銷售特點：
- 總結谷胱甘肽在壓力反應中的參與方式
- 彙編谷胱甘肽影響炎症反應的多種方式
- 揭示谷胱甘肽如何抑制程序性細胞死亡，例如鐵死亡（ferroptosis）
- 探索酶如何加速依賴谷胱甘肽的過程之謎
- 討論解毒和氧化還原調控如何通過谷胱甘肽化（glutathionylation）介導
- 回顧谷胱甘肽還原酶催化蛋白質二硫化物還原的方式
- 突顯與谷胱甘肽相關的代謝途徑對醫學的影響
- 說明病原體的硫醇代謝在藥物發現中的角色可能性
作者簡介
Leopold Flohé is Professor at the Universidad de la Republica Uruguay in Montevideo, Uruguay. He also Distinguishing Visiting Professor in the Department of Molecular Medicine at the University of Padova in Italy. He has been recognized by PubMed.gov as a Redox Pioneer because has published an article on antioxidant/redox biology, as first author, that has been cited more than 1,000 times, and more than 20 articles have been cited more than 100 times. He obtained the medical doctorate at the Institute of Pharmacology and Toxicology at the University of Tübingen, Germany, in 1968. He held positions in both Academia (Tübingen, Aachen, and Braunschweig, Germany) and industry (Aachen). He is now operating the biotech company MOLISA in Magdeburg, Germany, while teaching as guest professor at the local university. Dr. Flohé is the pioneer who established the selenoprotein nature of glutathione peroxidase (GPx), the first and, for almost 10 years, the only selenoprotein known in animals. His work was pivotal to link the essential trace element selenium to metabolic processes, which led the Food and Drug Administration (FDA) to approve selenium supplementation for humans in 1980, and stimulated selenium biochemistry in general. In recent years, he embarked on investigating how pathogens protect themselves from oxidative killing. His studies on the thiol-dependent hydroperoxide metabolism of trypanosomatids and mycobacteria defined molecular drug targets, paving the way to new therapeutic strategies for neglected diseases affecting the people of developing countries.
作者簡介(中文翻譯)
Leopold Flohé 是位於烏拉圭蒙特維多的烏拉圭共和國大學的教授。他同時也是意大利帕多瓦大學分子醫學系的特聘訪問教授。他因為發表了一篇關於抗氧化劑/氧化還原生物學的文章（第一作者），該文章被引用超過 1,000 次，因此被 PubMed.gov 認定為氧化還原先驅，並且有超過 20 篇文章被引用超過 100 次。他於 1968 年在德國圖賓根大學的藥理學和毒理學研究所獲得醫學博士學位。他曾在學術界（圖賓根、亞琛和布倫瑞克，德國）和產業界（亞琛）擔任職位。目前，他在德國馬格德堡經營生技公司 MOLISA，同時在當地大學擔任客座教授。Flohé 博士是首位確立谷胱甘肽過氧化物酶（GPx）為硒蛋白性質的先驅，這是動物中已知的第一種且在近 10 年內唯一的硒蛋白。他的研究對於將必需微量元素硒與代謝過程聯繫起來至關重要，這促使美國食品藥品監督管理局（FDA）於 1980 年批准人類補充硒，並刺激了硒生物化學的發展。近年來，他開始研究病原體如何保護自己免受氧化殺傷。他對於依賴硫醇的三尖體和分枝桿菌的過氧化氫代謝的研究確定了分子藥物靶點，為針對影響發展中國家人民的被忽視疾病的新治療策略鋪平了道路。
