Computational Exome and Genome Analysis
暫譯: 計算外顯子與基因組分析

Robinson, Peter N., Piro, Rosario Michael, Jager, Marten

  • 出版商: CRC
  • 出版日期: 2020-09-30
  • 售價: $2,100
  • 貴賓價: 9.5$1,995
  • 語言: 英文
  • 頁數: 557
  • 裝訂: Quality Paper - also called trade paper
  • ISBN: 0367657740
  • ISBN-13: 9780367657741
  • 相關分類: 生物資訊 Bioinformatics
  • 海外代購書籍(需單獨結帳)

相關主題

商品描述

Exome and genome sequencing are revolutionizing medical research and diagnostics, but the computational analysis of the data has become an extremely heterogeneous and often challenging area of bioinformatics. Computational Exome and Genome Analysis provides a practical introduction to all of the major areas in the field, enabling readers to develop a comprehensive understanding of the sequencing process and the entire computational analysis pipeline.

商品描述(中文翻譯)

外顯子組和基因組測序正在徹底改變醫學研究和診斷,但數據的計算分析已成為生物資訊學中一個極具異質性且常常具有挑戰性的領域。《計算外顯子組和基因組分析》提供了該領域所有主要領域的實用介紹,使讀者能夠全面理解測序過程及整個計算分析流程。

作者簡介

Peter Robinson is Professor for Medical Genomics at the Charité Universitätsmedizin Berlin, and professor for Bioinformatics at the Free University of Berlin. He studied Mathematics and Computer Science at Columbia University as well as Medicine at the University of Pennsylvania. Peter has led a bioinformatics research group since 2004. He has led the development of the Human Phenotype Ontology, which is used internationally to describe the clinical manifestations of patients with genetic disorders and to empower exome and genome analysis. His group has published algorithms for exome, genome, ChIP-seq and NGS T Cell Receptor profiling.

Rosario M. Piro is an Assistant Professor of Bioinformatics at Freie Universität Berlin and Charité-Universitätsmedizin Berlin, Germany. His research is mainly focused on computational neuropathology, including cancer genetics/genomics of brain tumors as well as network analysis and disease gene prediction for neurological disorders; and computational oncology in general, including the development and evolution of cancers in other organs or tissues. His expertise in next-generation sequencing data analysis techniques is complemented by a past research experience in the field of data-intensive distributed computing.



Marten Jäger is a graduate student in Peter Robinson's group and has developed pipelines for exome and genome sequencing data. Marten's work has involved the development of algorithms for variant annotation, exome prioritization, RNA-seq, and integrative genomics analysis.

作者簡介(中文翻譯)

彼得·羅賓森是柏林夏里特醫學大學的醫學基因組學教授,以及柏林自由大學的生物資訊學教授。他在哥倫比亞大學學習數學和計算機科學,並在賓夕法尼亞大學學習醫學。自2004年以來,彼得一直領導一個生物資訊學研究小組。他主導了人類表型本體(Human Phenotype Ontology)的開發,該本體在國際上用於描述遺傳疾病患者的臨床表現,並促進外顯子組和基因組分析。他的團隊已發表了針對外顯子、基因組、ChIP-seq和NGS T細胞受體分析的算法。



羅薩里奧·M·皮羅是德國柏林自由大學和夏里特醫學大學的生物資訊學助理教授。他的研究主要集中在計算神經病理學,包括腦腫瘤的癌症遺傳學/基因組學,以及神經疾病的網絡分析和疾病基因預測;還有一般的計算腫瘤學,包括其他器官或組織中癌症的發展和演變。他在下一代測序數據分析技術方面的專業知識,得益於他在數據密集型分佈式計算領域的過去研究經驗。



馬滕·耶格是彼得·羅賓森小組的研究生,並開發了外顯子和基因組測序數據的處理流程。馬滕的工作涉及變異註釋、外顯子優先排序、RNA-seq和整合基因組分析的算法開發。

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