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商品描述
Bioconductor software has become a standard tool for the analysis and comprehension of data from high-throughput genomics experiments. Its application spans a broad field of technologies used in contemporary molecular biology. In this volume, the authors present a collection of cases to apply Bioconductor tools in the analysis of microarray gene expression data. Topics covered include
* import and preprocessing of data from various sources
* statistical modeling of differential gene expression
* biological metadata
* application of graphs and graph rendering
* machine learning for clustering and classification problems
* gene set enrichment analysis
Each chapter of this book describes an analysis of real data using hands-on example driven approaches. Short exercises help in the learning process and invite more advanced considerations of key topics. The book is a dynamic document. All the code shown can be executed on a local computer, and readers are able to reproduce every computation, figure, and table.
商品描述(中文翻譯)
Bioconductor 軟體已成為分析和理解高通量基因組實驗數據的標準工具。它的應用涵蓋了當代分子生物學中使用的廣泛技術。在本卷中,作者呈現了一系列案例,以應用 Bioconductor 工具分析微陣列基因表達數據。涵蓋的主題包括:
* 從各種來源導入和預處理數據
* 差異基因表達的統計建模
* 生物元數據
* 圖形及圖形渲染的應用
* 用於聚類和分類問題的機器學習
* 基因集富集分析
本書的每一章都描述了使用實際數據的分析,採用以實例為驅動的方法。短小的練習有助於學習過程,並邀請對關鍵主題進行更深入的考量。本書是一份動態文檔。所有顯示的代碼都可以在本地計算機上執行,讀者能夠重現每一個計算、圖形和表格。
