Modeling and Simulating Cardiac Electrical Activity

This book provides a thorough introduction to the topic of mathematical modeling of electrical activity in the heart, from molecular details of ionic channel dynamics to clinically derived patient-specific models. It discusses how cellular ionic models are formulated, introduces commonly used models and explains why there are so many different models available. The chapters cover modeling of the intracellular calcium handling that underlies cellular contraction as well as modeling molecular-level details of cardiac ion channels, and specialized topics such as cardiomyocyte energetics and signalling pathways. It is an excellent resource for experienced and specialized researchers in the field, but also biological scientists with a limited background in mathematical modelling and computational methods.

Key Features

• Thorough introduction to the topic of mathematical modeling of electrical activity in the heart
• Focuses on use of experimental data in mathematical modeling, and on explanations rather than equations
• In addition to being experts in the field, the contributing authors are expert science communicators

Trine Krogh-Madsen received a MSc in applied physics from the Technical University of Denmark and a PhD in physiology from McGill University. She is an Associate Research Professor in the Department of Medicine and at the Institute for Computational Biomedicine at Weill Cornell Medicine, New York.

David J Christini received a BS in electrical engineering from the Pennsylvania State University, and a MS and PhD in biomedical engineering from Boston University. After nearly 20 years as faculty member at Weill Cornell Medicine, he is currently a Professor of physiology and pharmacology at SUNY Downstate Health Sciences University, Brooklyn NY, where he also serves as Senior Vice President for Research.