Next-Generation Sequencing: Standard Operating Procedures and Applications
暫譯: 下一代定序：標準作業程序與應用

Suravajhala, Prashanth N., Bizzaro, Jeff W.

Next-Generation Sequencing: Standard Operating Procedures and Applications
  • 出版商: CRC
  • 出版日期: 2025-05-30
  • 售價: $5,140
  • 貴賓價: 9.5 折 $4,883
  • 語言: 英文
  • 頁數: 278
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 1032392622
  • ISBN-13: 9781032392622

    • 尚未上市，無法訂購

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商品描述

This cutting-edge reference book compiles standard operating procedures, protocols, and applications of next-generation sequencing (NGS). It discusses genomic testing applications through NGS. It pays special focus on the protocols for cataloguing variants of uncertain significance. Over the years, NGS and advanced bioinformatics approaches have allowed the transition of genomic assays into translational practices. The book covers visualisation of NGS datasets, investigation of early development impairment, and metagenome protocols. It also discusses the challenges in NGS methods.

Key Points:

  • Includes case studies of application of NGS in different taxa like humans, rodents, plants, and bacteria
  • Compiles protocols from various reputed companies like Illumina, PacBio, and ThermoFisher
  • Discusses the translational applications of NGS methods
  • Reviews machine learning heuristics for NGS data interpretation
  • Discusses emerging genomic assay technologies and characterising mechanisms of disease prevalence

The book is meant for researchers and industry experts in genomics, computational biology, and bioinformatics.

Chapter 7 and 9 of this book is freely available as a downloadable Open Access PDF at http: //www.taylorfrancis.com under a Creative Commons [Attribution-Non Commercial-No Derivatives (CC BY-NC-ND)] 4.0 license.

商品描述(中文翻譯)

這本前沿的參考書匯編了標準操作程序、協議和下一代定序（next-generation sequencing, NGS）的應用。它探討了透過NGS進行基因組測試的應用，特別關注於不確定意義變異的目錄編制協議。多年來，NGS和先進的生物資訊學方法使基因組檢測轉變為轉譯實踐。該書涵蓋了NGS數據集的可視化、早期發展障礙的調查以及宏基因組協議。它還討論了NGS方法中的挑戰。

重點：
- 包含NGS在不同類群（如人類、囓齒動物、植物和細菌）中的應用案例研究
- 匯編了來自Illumina、PacBio和ThermoFisher等多家知名公司的協議
- 討論了NGS方法的轉譯應用
- 回顧了NGS數據解釋的機器學習啟發式方法
- 討論了新興的基因組檢測技術及其對疾病流行機制的特徵化

本書適合基因組學、計算生物學和生物資訊學的研究人員和行業專家。

本書的第7章和第9章可在http://www.taylorfrancis.com以可下載的開放存取PDF形式免費獲得，並遵循創用CC [署名-非商業性-禁止改作 (CC BY-NC-ND)] 4.0許可證。

作者簡介

Prashanth N Suravajhala is a Principal Scientist, Systems Biology at the Amrita School of Biotechnology, Kerala, India. He has a PhD in Systems Biology from Aalborg University, Denmark. His group has benchmarked pipelines and developed methods for systems genomic integration. He is an Associate Editor of Frontiers in Genetics/Systems Biology, Bio-Protocol, Biomolecules, and BMC Medical Genomics.

Jeff W Bizzaro has been involved in the field of bioinformatics for more than 25 years and has made significant contributions to the development of bioinformatics software. He is a co-founder of Bioinformatics.org, a professional network that advocates for open science and provides various resources to students and professionals.

作者簡介(中文翻譯)

Prashanth N Suravajhala 是印度喀拉拉邦阿姆里塔生物技術學院的系統生物學首席科學家。他擁有丹麥奧爾堡大學的系統生物學博士學位。他的研究小組已經建立了基準管道並開發了系統基因組整合的方法。他是《遺傳學前沿/系統生物學》、《生物協議》、《生物分子》和《BMC醫學基因組學》的副編輯。

Jeff W Bizzaro 在生物資訊學領域工作超過25年，對生物資訊學軟體的發展做出了重要貢獻。他是 Bioinformatics.org 的共同創辦人，這是一個倡導開放科學的專業網絡，並為學生和專業人士提供各種資源。

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