Computational Intelligence for Oncology and Neurological Disorders: Current Practices and Future Directions
暫譯: 腫瘤學與神經疾病的計算智慧：現行實務與未來方向

隨著基於計算智能的方法的興起，例如生物啟發技術，以及來自各種複雜實驗的臨床數據的可用性，醫療顧問、研究人員、神經科醫生和腫瘤科醫生在醫療腫瘤學和神經疾病領域中，基於計算智能的應用潛力巨大。本書專注於該領域的跨學科研究，將處理神經疾病和醫療腫瘤學的醫療從業人員與計算智能研究者聚集在一起。

本書收集了高品質的原創貢獻，包含最新的發展或實用價值的應用，呈現智能系統在計算腫瘤學和神經疾病領域的跨學科研究和綜述文章。它汲取了計算機科學、物理學、數學、醫學、心理學、認知科學、腫瘤學和神經生物學等領域的研究，結合了理論、應用、計算、實驗和臨床研究。對於任何專注於計算方法的神經學或腫瘤學研究人員來說，這本書將引起極大的興趣。

Dr. Mrutyunjaya Panda holds a Ph.D. degree in Computer Science from Berhampur University. He obtained his Master in Communication System Engineering from University College of Engineering, Burla, under Sambalpur University (Now, VSSUT, Burla), MBA in HRM from IGNOU, New Delhi, Bachelor in Electronics and Tele Communication Engineering from Utkal University. He is having 23 years of teaching and research experience and presently working as Associate Professor and Head in the Department of Computer Science and Applications, Utkal University, Vani Vihar, Bhubaneswar, Odisha, India. He is a member of KES (Australia), IAENG (Hong Kong), ACEEE(I), IETE(I), CSI(I), ISTE(I). He has published about 130 research papers in International and National journals and conferences of repute. He has also published 15 book chapters, edited five books in Springer, Taylor and Francis, IGI Global etc., Guest editor of International Journal of Computational Intelligence studies (IJCIStudies), Inderscience, UK and authored two text books on Soft Computing Techniques by Universal science press and Modern approaches of Data Mining by Narosa Publications to his credit. He is a program committee member of various international conferences. He is acting as a member of editorial board and active reviewer of various international journals and conferences. He is an Associate editor of International Journal of cognitive informatics and natural intelligence (IJCINI), IGI Global, USA and Journal of network and Innovative Computing (JNIC), MIR Labs, USA, Editorial board member of International Journal of knowledge engineering and soft data paradigms, (IJKESDP) Inderscience, UK, and reviewer of journals including: IEEE Access, Applied soft computing, Elsevier, Journal of King Saud University of computer and Information sciences, Elsevier, Wiley WIREs, Neural Computing and Applications, Springer to name a few. His active area of research includes Data Mining, Granular Computing, Big Data Analytics, Internet of Things, Intrusion detection system, Social networking, wireless sensor networks, Image Processing, Text and Opinion Mining and Bioinformatics, Natural language processing etc.

Dr. Ajith Abraham presently working as Dean of Faculty of Computing and Data Science at FLAME University, Pune India. Dr. Abraham was the Founding Director of Machine Intelligence Research Labs (MIR Labs), a Not-for-Profit Scientific Network for Innovation and Research Excellence connecting Industry and Academia. The Network with HQ in Seattle, USA has currently more than 1,000 scientific members from over 100 countries. As an Investigator / Co-Investigator, he has won research grants worth over 100+ Million US$ from Australia, USA, EU, Italy, Czech Republic, France, Malaysia and China. Dr. Abraham works in a multi-disciplinary environment involving machine intelligence, cyber-physical systems, Internet of things, network security, sensor networks, Web intelligence, Web services, data mining and applied to various real-world problems. In these areas he has authored / coauthored more than 1,400+ research publications out of which there are 100+ books covering various aspects of Computer Science. One of his books was translated to Japanese and few other articles were translated to Russian and Chinese. About 1,200+ publications are indexed by Scopus and over 1,000+ are indexed by Thomson ISI Web of Science. Some of the articles are available in the ScienceDirect Top 25 hottest articles. He has 1,100+ co-authors originating from 40+ countries. Dr. Abraham has nearly 50,000+ academic citations (h-index of 104 as per google scholar). He has given more than 150+ plenary lectures and conference tutorials (in 20+ countries). For his research, he has won seven best paper awards at prestigious International conferences held in Belgium, Canada Bahrain, Czech Republic, China and India. Since 2008, Dr. Abraham was the Chair of IEEE Systems Man and Cybernetics Society Technical Committee on Soft Computing (which has over 200+ members) and served as a Distinguished Lecturer of IEEE Computer Society representing Europe (2011-2013). Dr. Abraham was the editor-in-chief of Engineering Applications of Artificial Intelligence (EAAI) and serves/served the editorial board of over 15 International Journals indexed by Thomson ISI. He is actively involved in the organization of several academic conferences, and some of them are now annual events. Dr. Abraham received Ph.D. degree in Computer Science from Monash University, Melbourne, Australia (2001) and a Master of Science Degree from Nanyang Technological University, Singapore (1998). More information at: http: //www.softcomputing.net/

Dr Gopi Biju holds a M.B.B.S degree from Medical College, Trivandrum in the year 1981 and BCCPM (PALLIATIVE MEDICINE) from General Hospital, Ernakulam, in 2020. He is the recipient of the national fellowship of palliative medicine 2021-22, in institute of palliative medicine, calicut medical college, kozhokode, kerala, India and the global fellowship program in palliative medicine from Pallium India, Trivandrum, Kerala. He has worked as Consultant Palliative Physician, Palliative Physician and General Practitioner since 1984 till date in several medical colleges and hospitals suc as Khorfakkan Hospital, Sharjah, U.A.E and Pain and Palliative Care Dept, Lakeshore Hospital, Nettoor, Ernakulam, Kerala, India to name a few. He has very rich clinical experiences in and around the globe, some of which are as follows:

Clinical Experience and Job Description:

• Started the Pain and Palliative Home Care facilities for the first time in Lakeshore Hospital during the Covid Pandemic. Made all the SOPs for the smooth functioning of the Department. Extended the facility by opening IP facilities and admitting patients for Terminal care under Palliative Care Dept, Consultation for Palliative care from other in-house departments, like Oncology, Pulmonology, Cardiology, Neurology and Physical Rehabilitation. Home Care facility is well established now.
• Started a Joint Venture called "Doctor on Wheels" in Association with Signature Aged Care, Chalikkavattom, Ernakulam, Kerala with the view of providing Palliative and curative care especially for elderly patients who have difficulty in visiting doctors in the hospitals due to the restrictions due to the Lockdown during the Corona Pandemic. This has been a blessing for a lot of old people and their families who were in a dilemma as to what to do for the care of their aged relatives who could not be taken to hospitals for treatment and follow up.
• Worked in Peace Mission Centre, as Palliative Physician taking care of terminally ill patients with cancer and other end of stage chronically ill patients after obtaining my BCCPM course certification.
• Worked in Al Ghail Medical Centre, Al Ghail, R.A.K, as General Practitioner looking after workers in the Al Ghail Free Zone and the local patients residing in the area.
• Worked in Reem Al Nahda Medical Centre as General Practitioner conducting Family Medical Practice.
• Completed Basic life support course as per American Heart Association guidelines conducted by Eduscope International LLC, Dubai Health Care City, Dubai, U.A.E, and became a BLS Provider on 22nd August 2016

- In Metro Medical Centre and Dr. Sanjay Medical Centre, I was working as a General Practitioner looking after the company patients in the clinic as well as in the company clinics.

- Grand Sunny Medical Centre, is situated in the Industrial area no.2 in Sharjah, U.A.E. It is a part of Dr. Sunny Healthcare Group which is a well-established healthcare group in the Northern Emirates with several quality awards from the Govt. of Sharjah. I was the Medical Director and General Practitioner in the clinic which had a dental dept. and a female GP dept. in addition to the Male GP dept. We usually treated common illnesses and injuries among the labour class population who visited the clinic from the surrounding industrial area.

- In Vitalis Medical Centre, Bangalore, India, I was working as a General Practitioner doing all the routine general practice in the multispecialty clinic with state-of-the-art healthcare facilities.

- In Gopi Medical Clinic, Sharjah, I have set up a family practice clinic in 1993, in the Industrial area where low-income families and labourers were living, near their places of work. I was one of the first to implement a tailor-made Medical Insurance Policy for Factory workers in the area when no such medical insurance facility was available in the country. We had computerized our medical records from the inception of the clinic when it was a rarity in private practice. We had a system in place even in the early days for the safe disposal of hazardous medical waste when no such facility was available at that time.

- In Kuwaiti Hospital, Sharjah, I had worked in the Paediatric department and with the Anesthesiology Consultant had set up the Paediatric ICU and NICU. We used to manage critically ill children in our department without the need to refer to other tertiary hospital.

- In Khorfakkan Hospital, Sharjah, I joined the new Hospital in the Accident and Emergency Dept. which was not fully functional. On the instruction of the Director of the Hospital at the time, we made the A & E Dept. fully functional in time for the official opening of the Hospital by the Ruler of Sharjah in 1984.

- At present, he is working as Consultant Palliative Physician at Pain and Palliative Care Dept, Lakeshore Hospital, Nettoor, Ernakulam, Kerala, India. He is the member of the Indian Medical Association, Trivandrum Branch.

Dr. Reuel Ajith finished an MD degree in June 2021 from the Faculty of Medicine in Vilnius University, Lithuania. His research interests are in Internal medicine with a focus on neuro-degenerative diseases. He was in a team of researchers that developed the usage of artificial intelligence and free-speech to detect early signs of Parkinson's disease (https: //doi.org/10.1016/j.engappai.2018.09.018). The early detection mechanism used signal and speech processing techniques integrated with machine learning algorithms. He is affiliated with Machine Intelligence Research Labs (MIR Labs) dealing with AI and health care related projects.

**Dr. Mrutyunjaya Panda** 擁有來自 Berhampur University 的計算機科學博士學位。他在 Sambalpur University（現為 VSSUT, Burla）下的 University College of Engineering, Burla 獲得通信系統工程碩士學位，並在 IGNOU, 新德里 獲得人力資源管理 MBA，還在 Utkal University 獲得電子與電信工程學士學位。他擁有 23 年的教學和研究經驗，目前擔任印度奧里薩邦布巴內斯瓦爾 Utkal University 計算機科學與應用系的副教授及系主任。他是 KES（澳大利亞）、IAENG（香港）、ACEEE(I)、IETE(I)、CSI(I)、ISTE(I) 的成員。他在國際和國內知名期刊及會議上發表了約 130 篇研究論文，並出版了 15 篇書章，編輯了五本書籍，出版於 Springer、Taylor and Francis、IGI Global 等。他是《國際計算智能研究期刊》（IJCIStudies）的客座編輯，並著有兩本教科書，分別是《軟計算技術》（由 Universal Science Press 出版）和《數據挖掘的現代方法》（由 Narosa Publications 出版）。他是多個國際會議的程序委員會成員，並擔任多個國際期刊和會議的編輯委員會成員及活躍審稿人。他是《國際認知信息學與自然智能期刊》（IJCINI，IGI Global, USA）和《網絡與創新計算期刊》（JNIC，MIR Labs, USA）的副編輯，並擔任《國際知識工程與軟數據範式期刊》（IJKESDP，Inderscience, UK）的編輯委員會成員，還是包括 IEEE Access、Applied Soft Computing、Elsevier、King Saud University Journal of Computer and Information Sciences、Wiley WIREs、Neural Computing and Applications、Springer 等期刊的審稿人。他的研究主攻方向包括數據挖掘、粒狀計算、大數據分析、物聯網、入侵檢測系統、社交網絡、無線傳感器網絡、圖像處理、文本與意見挖掘及生物信息學、自然語言處理等。

**Dr. Ajith Abraham** 目前擔任印度浦那 FLAME University 計算與數據科學學院的院長。Dr. Abraham 曾是機器智能研究實驗室（MIR Labs）的創始主任，這是一個非營利科學網絡，旨在促進創新和研究卓越，連接產業與學術。該網絡總部位於美國西雅圖，目前擁有來自 100 多個國家的 1,000 多名科學成員。作為研究者/共同研究者，他獲得了來自澳大利亞、美國、歐盟、意大利、捷克共和國、法國、馬來西亞和中國的研究資助，總額超過 1 億美元。Dr. Abraham 在多學科環境中工作，涉及機器智能、網絡物理系統、物聯網、網絡安全、傳感器網絡、網絡智能、網絡服務、數據挖掘，並應用於各種現實世界問題。在這些領域，他已發表/共同發表超過 1,400 篇研究出版物，其中有 100 多本書籍涵蓋計算機科學的各個方面。他的一本書被翻譯成日文，其他幾篇文章則被翻譯成俄文和中文。約 1,200 篇出版物被 Scopus 索引，超過 1,000 篇被 Thomson ISI Web of Science 索引。一些文章在 ScienceDirect 的 25 篇最熱門文章中可見。他擁有來自 40 多個國家的 1,100 多位共同作者。Dr. Abraham 擁有近 50,000 次學術引用（根據 Google Scholar 的 h-index 為 104）。他在 20 多個國家發表了超過 150 次的全體講座和會議教程。因其研究，他在比利時、加拿大、巴林、捷克共和國、中國和印度的多個國際會議上獲得了七個最佳論文獎。自 2008 年以來，Dr. Abraham 擔任 IEEE 系統人與控制論學會軟計算技術委員會的主席（該委員會擁有超過 200 名成員），並於 2011-2013 年擔任 IEEE 計算機學會的傑出講師，代表歐洲。Dr. Abraham 曾擔任《工程應用人工智能》（EAAI）的主編，並服務於超過 15 本由 Thomson ISI 索引的國際期刊的編輯委員會。他積極參與多個學術會議的組織，其中一些會議現在已成為年度活動。Dr. Abraham 在澳大利亞墨爾本的莫納什大學獲得計算機科學博士學位（2001），並在新加坡南洋理工大學獲得理學碩士學位（1998）。更多信息請訪問：http://www.softcomputing.net/

**Dr. Gopi Biju** 於 1981 年獲得來自特里凡得琅醫學院的 M.B.B.S 學位，並於 2020 年獲得來自厄爾納庫拉姆總醫院的 BCCPM（緩和醫學）學位。他是 2021-22 年度印度卡利卡特醫學院緩和醫學研究所的國家緩和醫學獎學金獲得者，並獲得來自印度特里凡得琅的 Pallium India 的全球緩和醫學獎學金計劃。他自 1984 年以來一直擔任緩和醫學顧問醫生、緩和醫學醫生和全科醫生，工作於多所醫學院和醫院，如阿聯酋沙迦的 Khorfakkan 醫院和印度厄爾納庫拉姆的 Lakeshore 醫院的疼痛與緩和醫學部等。他在全球各地擁有豐富的臨床經驗，部分經歷如下：

**臨床經驗與工作描述：**

- 在 Covid 疫情期間，首次在 Lakeshore 醫院啟動疼痛與緩和居家護理設施。制定了所有標準作業程序以確保部門的順利運行。通過開設住院設施，為緩和醫學部提供終末期護理，並從其他內部科別（如腫瘤學、肺病學、心臟病學、神經學和物理康復）提供緩和醫學諮詢。居家護理設施現在已經建立良好。

- 與 Signature Aged Care 合作啟動了一個名為「Doctor on Wheels」的合資企業，旨在為因疫情封鎖而無法前往醫院就診的老年患者提供緩和和治療護理。這對許多面臨困境的老年人及其家庭來說是一種福音。

- 在和平使命中心擔任緩和醫學醫生，照顧末期癌症患者及其他慢性病末期患者，並獲得 BCCPM 課程證書。

- 在 Al Ghail 醫療中心擔任全科醫生，照顧 Al Ghail 自由區的工人及當地患者。

- 在 Reem Al Nahda 醫療中心擔任全科醫生，進行家庭醫學實踐。

- 根據美國心臟協會的指導方針，完成了由 Eduscope International LLC 在阿聯酋迪拜健康城舉辦的基本生命支持課程，並於 2016 年 8 月 22 日成為 BLS 提供者。

- 在 Metro 醫療中心和 Dr. Sanjay 醫療中心擔任全科醫生，照顧診所及公司診所的患者。

- Grand Sunny 醫療中心位於阿聯酋沙迦的工業區 2，是 Dr. Sunny Healthcare Group 的一部分，該集團在北阿聯酋享有良好的聲譽，並獲得了沙迦政府的多項質量獎項。我在診所擔任醫療主任和全科醫生，診所內設有牙科部和女性全科醫生部，除了男性全科醫生部。我們通常治療來自周邊工業區的勞工階層人口的常見疾病和傷害。

- 在印度班加羅爾的 Vitalis 醫療中心擔任全科醫生，進行多專科診所的常規全科醫學實踐，並擁有先進的醫療設施。

- 在沙迦的 Gopi 醫療診所，我於 1993 年在工業區設立了一家家庭診所，該地區居住著低收入家庭和勞工，靠近他們的工作地點。我是該地區首批為工廠工人實施量身定制的醫療保險政策的人之一，當時該國尚未提供此類醫療保險設施。我們從診所成立之初就對醫療記錄進行了電腦化，這在私人執業中是罕見的。我們在早期就建立了安全處理危險醫療廢物的系統，當時並沒有此類設施。

- 在沙迦的科威特醫院，我曾在兒科部工作，並與麻醉科顧問一起設立了兒科重症監護室和新生兒重症監護室。我們在部門內管理危重病兒，無需轉診至其他三級醫院。

- 在沙迦的 Khorfakkan 醫院，我加入了新醫院的急診部，該部門尚未完全運行。在當時醫院主任的指示下，我們使急診部在 1984 年沙迦統治者正式開幕前完全運行。

- 目前，他在印度厄爾納庫拉姆的 Lakeshore 醫院疼痛與緩和醫學部擔任顧問緩和醫學醫生。他是印度醫學會特里凡得琅分會的成員。

**Dr. Reuel Ajith** 於 2021 年 6 月在立陶宛維爾紐斯大學醫學院獲得醫學博士學位。他的研究興趣集中在內科，特別是神經退行性疾病。他曾參與一個研究團隊，開發使用人工智能和自由語音來檢測帕金森病早期跡象的技術（https://doi.org/10.1016/j.engappai.2018.09.018）。該早期檢測機制使用信號和語音處理技術，並結合機器學習算法。他與機器智能研究實驗室（MIR Labs）有關聯，專注於人工智能和醫療保健相關項目。