Rodent Models of Neurodegenerative Disease
暫譯: 神經退行性疾病的齧齒動物模型
Javadpour, Pegah, Ghasemi, Rasoul
- 出版商: CRC
- 出版日期: 2026-03-26
- 售價: $7,940
- 貴賓價: 9.8 折 $7,781
- 語言: 英文
- 頁數: 150
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 103266049X
- ISBN-13: 9781032660493
海外代購書籍(需單獨結帳)
商品描述
Rodent Models of Neurodegenerative Disease explores neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Lewy body disease, and prion disease which represent some of the most complex and devastating challenges in neuroscience. With rising prevalence in aging populations worldwide, these disorders place immense burdens on patients, families, and healthcare systems. This comprehensive volume, Rodent Models of Neurodegenerative Disease, provides an in-depth examination of the utility, strengths, and limitations of rodent models in unraveling the molecular, cellular, and behavioral aspects of neurodegeneration. Organized by disease, each chapter explores both genetic and non-genetic models, highlighting their relevance to human pathology, translational value, and contributions to therapeutic discovery.
Key features of this book include the following:
- Detailed coverage of rodent models for major neurodegenerative diseases.
- Critical analysis of disease mechanisms, from protein aggregation and mitochondrial dysfunction to neuroinflammation and synaptic loss.
- A dedicated chapter on behavioral assays, bridging molecular pathology with motor, cognitive, and social outcomes. Insights into the translational challenges of preclinical research and its role in shaping future therapies. With contributions from leading neuroscientists, this book serves as a valuable reference for researchers, graduate students, and professionals in neuroscience, neurology, pharmacology, and related fields. Whether for experimental design, model selection, or therapeutic evaluation, it provides an essential guide for advancing neurodegenerative disease research.
About the Editors:
Dr. Pegah Javadpour, PhD, is Assistant Professor of Medical Physiology at the Neuroscience Research Center, Institute of Neuroscience and Cognition, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Her research focuses on mitochondrial dysfunction, oxidative stress, and neuroinflammation in neurodegenerative disorders, particularly Parkinson's and Alzheimer's diseases. She has a special interest in mitochondria-targeted therapeutic strategies, including mitochondrial transplantation therapy (mitotherapy), as potential treatments for these conditions.
Dr. Rasoul Ghasemi, PhD, is Associate Professor of Physiology in the Department of Physiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. His research explores the neurophysiology of learning and memory, with emphasis on insulin signaling, hippocampal function, neuroinflammation, oxidative stress, and neuroprotection in neurodegenerative diseases. He has published extensively on the cellular and molecular mechanisms underlying brain resilience and pathology.
商品描述(中文翻譯)
《啮齒動物神經退行性疾病模型》探討了如阿茲海默症、帕金森病、亨廷頓舞蹈症、肌萎縮側索硬化症、額顳葉癡呆、路易體病及朊病毒病等神經退行性疾病，這些疾病代表了神經科學中一些最複雜且毀滅性的挑戰。隨著全球老年人口的增加，這些疾病對患者、家庭及醫療系統造成了巨大的負擔。本書《啮齒動物神經退行性疾病模型》提供了對啮齒動物模型在揭示神經退行性疾病的分子、細胞及行為方面的效用、優勢及限制的深入探討。每一章根據疾病進行組織，探討了遺傳及非遺傳模型，強調其與人類病理的相關性、轉化價值及對治療發現的貢獻。
本書的主要特色包括：
- 詳細介紹主要神經退行性疾病的啮齒動物模型。
- 對疾病機制的批判性分析，涵蓋從蛋白質聚集、線粒體功能障礙到神經炎症及突觸損失等方面。
- 專門章節探討行為測試，將分子病理與運動、認知及社交結果相連接。深入了解臨床前研究的轉化挑戰及其在塑造未來治療中的角色。本書由領先的神經科學家撰寫，對於神經科學、神經學、藥理學及相關領域的研究人員、研究生及專業人士來說，都是一部寶貴的參考資料。無論是實驗設計、模型選擇還是治療評估，本書都提供了推進神經退行性疾病研究的必要指導。
編輯介紹：
佩嘉·賈瓦杜爾博士（Dr. Pegah Javadpour），博士，伊朗德黑蘭沙希德·貝赫什提醫科大學神經科學研究中心醫學生理學助理教授。她的研究專注於神經退行性疾病中的線粒體功能障礙、氧化壓力及神經炎症，特別是帕金森病和阿茲海默症。她對以線粒體為目標的治療策略（包括線粒體移植療法）特別感興趣，這些策略被視為這些疾病的潛在治療方法。
拉蘇爾·卡西米博士（Dr. Rasoul Ghasemi），博士，伊朗德黑蘭沙希德·貝赫什提醫科大學生理學系副教授。他的研究探討學習和記憶的神經生理學，重點關注胰島素信號傳導、海馬體功能、神經炎症、氧化壓力及神經保護在神經退行性疾病中的作用。他在大腦韌性及病理的細胞和分子機制方面發表了大量研究。
作者簡介
Dr. Pegah Javadpour, PhD, is Assistant Professor of Medical Physiology at the Neuroscience Research Center, Institute of Neuroscience and Cognition, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Her research focuses on mitochondrial dysfunction, oxidative stress, and neuroinflammation in neurodegenerative disorders, particularly Parkinson's and Alzheimer's diseases. She has a special interest in mitochondria-targeted therapeutic strategies, including mitochondrial transplantation therapy (mitotherapy), as potential treatments for these conditions.
Dr. Rasoul Ghasemi, PhD, is Associate Professor of Physiology in the Department of Physiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. His research explores the neurophysiology of learning and memory, with emphasis on insulin signaling, hippocampal function, neuroinflammation, oxidative stress, and neuroprotection in neurodegenerative diseases. He has published extensively on the cellular and molecular mechanisms underlying brain resilience and pathology.
作者簡介(中文翻譯)
佩嘉·賈瓦杜爾博士，哲學博士，是伊朗德黑蘭沙希德·貝赫什提醫科大學神經科學研究中心的醫學生理學助理教授。她的研究專注於神經退行性疾病中的線粒體功能障礙、氧化壓力和神經炎症，特別是帕金森病和阿茲海默病。她對以線粒體為目標的治療策略，包含線粒體移植療法（mitotherapy），作為這些疾病的潛在治療方法特別感興趣。
拉蘇爾·卡塞米博士，哲學博士，是伊朗德黑蘭沙希德·貝赫什提醫科大學生理學系的副教授。他的研究探討學習和記憶的神經生理學，重點關注胰島素信號傳導、海馬體功能、神經炎症、氧化壓力和神經保護在神經退行性疾病中的作用。他在大腦韌性和病理學的細胞及分子機制方面發表了大量研究。
