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商品描述
This is a second edition of a book that provides an overview of the most current findings on the diverse roles played by astrocytes in the function and dysfunction of the central nervous system (CNS), with emphasis on their cellular connections. Astrocytes are highly elaborated cells and likely the only neural cells that simultaneously establish associations with different cellular types. The fine processes of astrocytes are found in practically all nearby cellular types in the CNS, including astrocytes themselves, neurons, oligodendrocytes, microglia, and brain endothelial cells. Such close morphological associations, together with the fact that astrocytes express a multitude of ion channels, transporters, and membrane receptors, endow these cells with the unique capability to sense and influence diverse CNS functions. Disruption of these elaborated connections and altered astrocyte polarization are implicated in numerous pathological conditions, such as epilepsy, stroke, leukodystrophies, Alzheimer's, and autism, and also certain psychiatric disorders, major depression, and schizophrenia.
商品描述(中文翻譯)
這是一本第二版的書籍，提供了有關星形膠質細胞在中樞神經系統（CNS）功能與失調中所扮演的多樣角色的最新研究概述，特別強調它們的細胞連結。星形膠質細胞是高度發達的細胞，可能是唯一同時與不同細胞類型建立聯繫的神經細胞。星形膠質細胞的細微突起幾乎存在於CNS中所有鄰近的細胞類型，包括星形膠質細胞本身、神經元、少突膠質細胞、小膠質細胞和腦內皮細胞。這種緊密的形態學聯繫，加上星形膠質細胞表達多種離子通道、運輸蛋白和膜受體，使這些細胞具備感知和影響多樣CNS功能的獨特能力。這些精細的連結被破壞以及星形膠質細胞極化的改變與多種病理狀況有關，如癲癇、中風、白質發育不良、阿茲海默症、自閉症，以及某些精神疾病、重度憂鬱症和精神分裂症。
作者簡介
Dr. Eliana Scemes is a professor at New York Medical College. She obtained her Ph.D. in general physiology from the University of Sao Paulo, Brazil, and obtained further postdoctoral training in neurobiology in Brazil and in neuroscience at Albert Einstein College of Medicine. Her research has made significant contributions to the understanding of astrocyte biology, focusing on gap junction proteins (connexins and pannexins) and their impact on CNS physiopathology. She has contributed over 100 publications, with an h-index of 49, in the form of research and review articles and book chapters, and has been a member of numerous professional societies and the editorial board member of many scientific journals.
Dr. David C. Spray is a professor in the Dominick P. Purpura Department of Neuroscience and Department of Medicine at Albert Einstein College of Medicine and an adjunct professor of biomedical engineering at the City College of New York. His Ph.D. in physiology at the University of Florida College of Medicine, supported by one of the first Centers for Neuroscience, dealt with transduction properties of peripheral sensory neurons. As a Grass Foundation Fellow and for more than a dozen years afterward, he spent summers doing research at the Marine Biological Laboratory in Woods Hole, MA. His primary research focus has been on gap junctions, where current research of the laboratory focuses on neuron-glial interactions in peripheral ganglia associated with several models of chronic pain and gap junction control of the blood-brain barrier at the astrocyte endfeet. Dr. Spray has published about 500 papers, with an h-index >100, and with Dr. Scemes, he has co-authored more than 50 original articles and reviews, primarily dealing with gap junctions and astrocytes. He has served on NIH study sections, including Molecular and Cellular Biology of Glia, which he chaired, and is on the editorial boards of numerous journals, including Glia.
作者簡介(中文翻譯)
Dr. Eliana Scemes 是紐約醫學院的教授。她在巴西聖保羅大學獲得一般生理學的博士學位，並在巴西接受神經生物學的博士後訓練，以及在阿爾伯特·愛因斯坦醫學院接受神經科學的博士後訓練。她的研究對於理解星形膠質細胞生物學做出了重要貢獻，專注於間隙連接蛋白（connexins 和 pannexins）及其對中樞神經系統生理病理學的影響。她發表了超過100篇論文，h-index 為49，包括研究文章、綜述文章和書籍章節，並且是多個專業學會的成員以及許多科學期刊的編輯委員會成員。
Dr. David C. Spray 是阿爾伯特·愛因斯坦醫學院的多米尼克·P·普爾普拉神經科學系和內科系的教授，同時也是紐約市立大學生物醫學工程的兼任教授。他在佛羅里達大學醫學院獲得生理學的博士學位，該學位由第一個神經科學中心之一支持，研究周邊感覺神經元的轉導特性。作為草根基金會的研究員，並在隨後的十多年中，他在麻薩諸塞州伍茲霍爾的海洋生物實驗室進行夏季研究。他的主要研究重點是間隙連接，實驗室目前的研究專注於與幾種慢性疼痛模型相關的周邊神經節中的神經元-膠質細胞相互作用，以及在星形膠質細胞末端對血腦屏障的間隙連接控制。Dr. Spray 發表了約500篇論文，h-index 超過100，並與 Dr. Scemes 共同撰寫了超過50篇原創文章和綜述，主要涉及間隙連接和星形膠質細胞。他曾在 NIH 研究小組中任職，包括他擔任主席的膠質細胞的分子與細胞生物學，並且是多個期刊的編輯委員會成員，包括《Glia》。
