Cancer Hypoxia: Implication in Therapeutics and Precision Oncology
暫譯: 癌症缺氧：對治療與精準腫瘤學的影響

這本書全面回顧了缺氧在癌症發生和進展中的角色。它探討了缺氧驅動的信號通路以及缺氧腫瘤中的免疫微環境，提供了對癌症發展和治療的網絡影響的見解，以及應對缺氧引起的免疫抑制的策略。書中調查了缺氧對癌症幹細胞和細胞幹性（stemness）的影響，強調了其在缺氧環境中維持幹性的角色及潛在的治療機會。該書進一步探討了檢測缺氧表型的工具和技術，以及用於研究缺氧癌症、血管生成和缺氧腫瘤中的血管重塑的體內模型，討論了創新的藥物傳遞和針對缺氧誘導因子的策略。最後，它概述了缺氧研究在癌症治療中的臨床應用，涵蓋了從放射策略的進展到生物標記、診斷、精準醫療以及未來缺氧活化前藥研究的方向。這本全面的資源為研究人員、臨床醫生和從事理解和對抗癌症缺氧的專業人士提供了寶貴的參考。

主要特點
- 提供了缺氧在癌症發生和進展中的角色的徹底回顧
- 呈現了腫瘤中複雜的缺氧驅動信號通路及其對癌症發展和治療的影響
- 缺氧在維持缺氧環境中幹性及潛在治療機會的角色
- 討論了在缺氧腫瘤微環境中增強藥物療效的方法
- 探索針對缺氧腫瘤血管的治療方法

Sukhes Mukherjee is a highly esteemed academic and researcher currently serving as an Additional Professor in the Department of Biochemistry at AIIMS Bhopal, India. With over 18 years of dedicated experience in teaching and research, he has established himself as a prominent figure in the fields of cancer biology, biochemistry, and molecular biology. His prolific scholarly output includes more than 120 peer-reviewed publications, 8 edited books, reflecting his deep engagement with cutting-edge scientific inquiry and his commitment to advancing knowledge in his field. His leadership and expertise are recognized globally, evidenced by his active participation in numerous scientific societies; he is a Fellow of the Linnean Society (UK) and the Royal Society for Medicine, a member of the Royal Society of Biology (UK), a member of National Academy of Medical Sciences (India) and a Clinical Scientist of the American Society of Clinical Pathology, among others. His contributions have been acknowledged through prestigious awards such as the ISSN Award from the International Science and Technology Organization (2023), the Farha Deeba Haq Award from the Indian Academy of Biomedical Sciences (2024), and the Blackbucks Award from Medical Dialogues (2024). Furthermore, his dedication to advancing biomedical sciences, combined with his commitment to education and professional development, positions him as a leading figure in the global scientific community. Dr. Mukherjee's commitment to fostering a vibrant scientific community is evident through his active engagement in organizing conferences, symposiums, and scientific forums that facilitate knowledge dissemination and networking among researchers. Dr. Mukherjee's unwavering commitment to advancing science, fostering collaboration, and mentoring future leaders exemplifies his role as a pioneer in his field. His multifaceted career reflects a blend of scientific rigor, educational passion, and leadership acumen, making him a highly influential figure whose work continues to inspire and shape the future of biomedical sciences worldwide.

Suman Kumar Ray is a highly dedicated and accomplished researcher whose career spans over 15 years of rigorous investigation in the fields of Molecular Biology and Cancer Research. Throughout his esteemed career, he has authored more than 85 peer-reviewed research articles, contributed over several comprehensive book chapters, and presented his groundbreaking work at numerous prestigious national and international conferences, establishing himself as a prominent voice in the oncology community. His expertise in the study of hypoxia and its profound implications in tumor biology has earned him widespread recognition, reflected in his extensive publication record and invitations to deliver lectures at various academic institutions across India. Dr. Ray maintains active and influential affiliations with leading oncology-related organizations, including the American Association for Cancer Research, where he is involved in collaborative research and knowledge dissemination, and he also serves as an ambassador for the European Association for Cancer Research, promoting international cooperation in cancer science. Dr. Ray seamlessly integrates pioneering oncology research with strategic innovation, forging collaborative pathways and advancing scientific frontiers in public health through his dedicated laboratory expertise and visionary leadership. His academic journey is marked by several National Fellowships, which laid the foundation for his innovative research approach and he continues to make significant contributions through his research, editorial work for scientific journals, and content development in oncology. His unwavering commitment to advancing cancer research is complemented by his dedication to mentoring young researchers and engaging in public outreach. Dr. Ray's diverse interests and passions exemplify a well-rounded personality committed to both scientific excellence and personal growth, inspiring colleagues and apprentices alike in the pursuit of knowledge and innovation in cancer research.

Sukhes Mukherjee 是一位備受尊敬的學者和研究者，目前擔任印度博帕爾醫學科學院（AIIMS Bhopal）生物化學系的附加教授。擁有超過 18 年的教學和研究經驗，他在癌症生物學、生物化學和分子生物學領域中已建立起顯著的地位。他的學術成果豐碩，包括超過 120 篇經過同行評審的出版物和 8 本編輯書籍，反映出他對前沿科學研究的深度參與以及推進其領域知識的承諾。他的領導能力和專業知識在全球範圍內受到認可，這從他積極參與眾多科學學會中可見一斑；他是英國林奈學會（Linnean Society）和皇家醫學學會（Royal Society for Medicine）的院士，英國生物學學會（Royal Society of Biology）成員，印度醫學科學國家學院（National Academy of Medical Sciences）成員，以及美國臨床病理學會（American Society of Clinical Pathology）的臨床科學家等。他的貢獻獲得了多項榮譽獎項的肯定，如國際科學與技術組織（International Science and Technology Organization）頒發的 ISSN 獎（2023）、印度生物醫學科學學院（Indian Academy of Biomedical Sciences）頒發的 Farha Deeba Haq 獎（2024），以及醫療對話（Medical Dialogues）頒發的 Blackbucks 獎（2024）。此外，他對推進生物醫學科學的奉獻，加上對教育和專業發展的承諾，使他成為全球科學界的領軍人物。Mukherjee 博士對促進活躍的科學社群的承諾，通過他積極參與組織會議、研討會和科學論壇，促進研究者之間的知識傳播和網絡交流，得以體現。Mukherjee 博士對推進科學、促進合作和指導未來領導者的堅定承諾，展現了他在其領域中的先驅角色。他多元化的職業生涯反映出科學嚴謹性、教育熱情和領導才能的結合，使他成為一位極具影響力的人物，其工作持續激勵並塑造全球生物醫學科學的未來。

Suman Kumar Ray 是一位高度專注且成就卓越的研究者，其職業生涯跨越了超過 15 年的分子生物學和癌症研究的嚴謹調查。在他卓越的職業生涯中，他撰寫了超過 85 篇經過同行評審的研究文章，貢獻了多篇綜合性書籍章節，並在眾多國內外的知名會議上展示了他的開創性工作，確立了他在腫瘤學界的顯著聲音。他在缺氧及其對腫瘤生物學深遠影響的研究專業，使他獲得了廣泛的認可，這在他豐富的出版記錄和受邀在印度各大學術機構演講中得以體現。Ray 博士與多個領先的腫瘤學相關組織保持著活躍且有影響力的聯繫，包括美國癌症研究協會（American Association for Cancer Research），他在其中參與合作研究和知識傳播，並擔任歐洲癌症研究協會（European Association for Cancer Research）的大使，促進癌症科學的國際合作。Ray 博士將開創性的腫瘤學研究與戰略創新無縫結合，通過他專注的實驗室專業知識和前瞻性領導，開創合作途徑並推進公共衛生的科學前沿。他的學術旅程標誌著多項國家獎學金，為他的創新研究方法奠定了基礎，他繼續通過研究、科學期刊的編輯工作和腫瘤學內容的開發做出重要貢獻。他對推進癌症研究的堅定承諾，與他對指導年輕研究者和參與公共宣傳的奉獻相輔相成。Ray 博士的多元興趣和熱情體現了一個致力於科學卓越和個人成長的全面人格，激勵著同事和學徒在追求癌症研究的知識和創新中不斷前行。