Nanomedicine and Applications in Cancer: A Complete Guide to Nanomedicine and Cancer Applications
暫譯: 奈米醫學與癌症應用：奈米醫學與癌症應用的完整指南

納米醫學代表了癌症治療的一次範式轉變，提供了靶向藥物傳遞、降低全身毒性和提高療效。本書詳細而系統地概述了納米醫學配方及其在癌症治療領域的多樣應用。

本書從納米顆粒合成、特徵化及其在醫學中的應用的基本原則開始，然後探討關鍵的納米顆粒平台。針對聚合物基納米顆粒，考察其材料特性、生產方法及其在開發量身定制的癌症療法中的角色。一個專門的部分討論了脂質基納米顆粒，重點關注生物傳遞的複雜性、臨床成功案例以及穩定性和儲存的基本考量。自生成納米乳液（SGNEs）被引入作為提高藥物生物利用度和克服抗藥性的一種策略，並關注臨床轉化的監管途徑。

本書進一步闡明了靶向藥物傳遞，詳細介紹了通過各種配體的被動和主動靶向機制。納米醫學的診斷應用也被呈現，重點在於螢光納米顆粒、其特徵化、生物醫學用途、臨床試驗狀態以及與其他診斷方式相比的局限性。

關鍵領域如癌症免疫療法，包括預防性和治療性疫苗及腫瘤溶解病毒，以及不斷發展的基於RNA的療法，強調納米技術在其穩定性和靶向傳遞中的作用，均被徹底討論。文本最後概述了CAR-T細胞療法、相關挑戰、創新工程策略如CRISPR/Cas9、納米顆粒介導的基因傳遞及相關的臨床進展。最後，本書探討了阻礙癌症靶向納米醫學臨床轉化的多方面障礙，提出潛在解決方案和設計考量，以優化臨床結果。

Professor Imran Saleem is a distinguished Professor of Nanomedicine and leads the Nanomedicine, Formulation and Delivery Research Group within the School of Pharmacy & Biomolecular Sciences at Liverpool John Moores University, UK. He obtained his Pharmacy degree and registration as a practicing pharmacist from the same institution before earning a Ph.D. in drug delivery from Aston University, UK, in 2004.

Following his doctoral studies, Professor Saleem pursued a Postdoctoral Research Fellowship at the University of New Mexico, USA, where his research focused on dry powder inhalation for targeted delivery of anticancer agents in lung cancer. His interdisciplinary research integrates formulation science, drug delivery, nanotechnology, polymer science, chemistry, and cell and molecular biology.

Professor Saleem's current research centers on the application and fundamental understanding of novel nanocarrier systems designed to overcome biological barriers for the targeted delivery of diverse therapeutic agents, including small molecules and macromolecules, for both human and veterinary applications.

With over two decades of experience in nanoparticle formulation and drug delivery systems, Professor Saleem is a prominent figure in the field, evidenced by numerous publications in leading peer-reviewed journals, presentations at international conferences, and contributions to book chapters. His leadership continues to drive innovation in nanomedicine and drug delivery, with the potential for significant impact on therapeutic outcomes.

Professor Dr. Ahmed AH Abdellatif is a Professor at the College of Pharmacy, Qassim University, Saudi Arabia, with over two decades of research and teaching experience in pharmaceutical technology and drug delivery systems. He commenced his academic journey in Egypt, earning his Bachelor's and Master of Science degrees from Al-Azhar University, where he also served as a lecturer and professor. Registered as a pharmacist with the Egyptian Ministry of Health since 2001, Professor Abdellatif pursued his Ph.D. in Pharmaceutical Technology at the University of Regensburg, Germany, gaining expertise in drug formulation and delivery at the Institute of Chemistry and Pharmacy.

Professor Abdellatif is a leading researcher in nanobiotechnology, specializing in the synthesis and characterization of metal and polymeric nanoparticles and their applications in cell biology and biotechnology. His prolific research output includes over 100 publications, reflecting his comprehensive understanding of modern advancements in drug formulation, nanobiotechnology, and receptor targeting. His work has significantly contributed to the understanding of nanoparticle-based therapeutics for combating cancer and infectious diseases, with the potential to improve patient care globally.

Professor Dr. Ahmed AH Abdellatif's leadership in pharmaceutics, combining a strong educational foundation with practical research applications, continues to make a significant impact both within Saudi Arabia and internationally, driving advancements in pharmaceutical technology.

伊姆蘭·薩利姆教授是納米醫學領域的傑出教授，並在英國利物浦約翰摩爾斯大學的藥學與生物分子科學學院領導納米醫學、配方與傳遞研究小組。他在同一機構獲得藥學學位並註冊為執業藥師，隨後於2004年在英國阿斯頓大學獲得藥物傳遞的博士學位。

在完成博士學位後，薩利姆教授在美國新墨西哥大學追求博士後研究獎學金，研究重點是針對肺癌的抗癌劑的乾粉吸入劑的目標傳遞。他的跨學科研究整合了配方科學、藥物傳遞、納米技術、高分子科學、化學以及細胞和分子生物學。

薩利姆教授目前的研究集中在新型納米載體系統的應用及其基本理解，這些系統旨在克服生物障礙，以便針對性地傳遞各種治療劑，包括小分子和大分子，應用於人類和獸醫領域。

擁有超過二十年的納米顆粒配方和藥物傳遞系統的經驗，薩利姆教授在該領域中是一位重要人物，這從他在頂尖同行評審期刊上的多篇發表、國際會議的演講以及對書籍章節的貢獻中可見一斑。他的領導力持續推動納米醫學和藥物傳遞的創新，對治療結果有著顯著的影響潛力。

艾哈邁德·AH·阿卜杜拉提夫教授博士是沙烏地阿拉伯卡西姆大學藥學院的教授，擁有超過二十年的藥物技術和藥物傳遞系統的研究與教學經驗。他的學術旅程始於埃及，在阿茲哈爾大學獲得學士和碩士學位，並擔任講師和教授。自2001年以來，他已在埃及衛生部註冊為藥師，並在德國雷根斯堡大學獲得藥物技術的博士學位，專注於藥物配方和傳遞的化學與藥學研究所。

阿卜杜拉提夫教授是納米生物技術領域的領先研究者，專注於金屬和聚合物納米顆粒的合成與表徵及其在細胞生物學和生物技術中的應用。他的研究成果豐碩，發表超過100篇論文，反映出他對藥物配方、納米生物技術和受體靶向現代進展的全面理解。他的工作對於理解基於納米顆粒的治療方法以對抗癌症和傳染病做出了重要貢獻，並有潛力改善全球患者的護理。

艾哈邁德·AH·阿卜杜拉提夫教授博士在藥物學領域的領導力，結合了堅實的教育基礎與實用的研究應用，持續在沙烏地阿拉伯及國際上產生重大影響，推動藥物技術的進步。