Nanotechnology in Diabetes: Advancements in Diagnosis, Therapy, and Personalized Care
暫譯: 糖尿病奈米科技：診斷、治療與個人化照護的進展

《糖尿病奈米技術：診斷、治療與個人化照護的進展》探討奈米技術在糖尿病診斷、治療及長期管理上的應用。開篇章節概述糖尿病、其盛行情形、複雜性，以及目前管理技術的限制。本書也探討奈米技術在再生醫學中的作用，尤其是其在胰島細胞再生方面的潛力。此外，本書回顧奈米生物感測器（nano-biosensors）在連續血糖監測方面的發展，強調其進行精確、即時血糖監測的潛力，進而改善患者的治療成效。書中亦討論奈米技術在個人化醫療中的作用，根據個別患者的特徵量身訂製治療計畫，為糖尿病照護提供客製化方法。接著，本書檢視將奈米技術整合至臨床實務時所涉及的倫理、法規與實務考量。最後，本書討論此領域的新興趨勢與未來創新，並介紹目前持續進行且可望推動未來糖尿病管理發展的研究。

主要特色

• 探討奈米技術在改變糖尿病管理方面的潛力，涵蓋血糖監測至先進藥物遞送系統等領域。
• 探索奈米技術根據個別患者特徵實現糖尿病治療個人化的潛力，以提供更有效的照護。
• 提供奈米技術應用於胰島細胞再生的前沿見解，為糖尿病的長期解決方案帶來希望。
• 討論將奈米技術整合至糖尿病照護臨床環境中所面臨的倫理、法規與實務挑戰。
• 強調可能透過奈米技術徹底革新糖尿病治療未來的新興研究、未來創新與發展趨勢。

因此，本書適合奈米技術、藥學、生物醫學工程及再生醫學領域的研究人員與專業人士閱讀。

Pankaj Sharma is a Professor of Pharmaceutics and Head of the Department at ShriRam College of Pharmacy, Banmore, Morena (M.P.), India, with over 14 years of teaching and research experience in pharmaceutical sciences. He earned his PhD in Pharmaceutical Sciences from Jiwaji University, Gwalior, where his doctoral research focused on the development of nanoemulsion-based transdermal drug delivery systems for malaria therapy. He also holds an M.Pharm in Pharmaceutics, supported by an AICTE-GPAT fellowship.

Dr. Sharma's research interests span nanomedicine, smart polymers, transdermal and targeted drug delivery systems, pharmaceutical nanotoxicology, artificial intelligence in healthcare, and advanced formulation development. He has made significant contributions to academia through 60+ peer-reviewed publications, including articles in Scopus- and Web of Science-indexed journals, along with numerous book chapters published by leading international publishers.

He is the editor/author of multiple international books published or accepted by CRC Press, Elsevier, Apple Academic Press (Taylor & Francis), and Bentham Science, and actively contributes to interdisciplinary research at the intersection of nanotechnology, AI, and personalized medicine. Dr. Sharma is also an approved M.Pharm guide, having successfully supervised several postgraduate research projects.

In recognition of his academic excellence, he has received the "Best Doctorate Award" from the Indian Pharma Educational Society and holds a UK design patent for a smart pharmaceutical monitoring system. His commitment to teaching, research mentorship, and innovation continues to support the advancement of pharmaceutical education and translational research.

Shashi Ravi Suman Rudrangi is a Chartered Scientist and senior pharmaceutical leader with over 14 years of international experience spanning formulation research and development, Manufacturing Science and Technology (MSAT), end-to-end Chemistry, Manufacturing and Controls (CMC) strategy, and the commercialisation of oral solid dosage products. He currently serves as Associate Director, CMC Drug Product Manufacturing, at Olema Oncology in Dublin, Ireland. where he leads strategic CMC manufacturing activities supporting the development and commercialisation of innovative oncology therapies.

Prior to joining Olema Oncology, Dr Rudrangi served as Senior Drug Product Development and Commercialisation Manager (Technical Head) at Kent-Athlone Pharma Group in the United Kingdom and Ireland, where he led multidisciplinary teams responsible for the development and scale-up of oral solid dosage formulations. Throughout his career, he has directed complex technology transfer programmes and contributed to the successful commercial launch of pharmaceutical products across multiple European markets. His expertise includes formulation and process development, Quality by Design (QbD), process validation, GMP manufacturing, and product lifecycle management.

Dr. Rudrangi earned his PhD in Pharmaceutics and MSc in Formulation Science from the University of Greenwich, UK, and a Bachelor of Pharmacy from Kakatiya University, India. His research interests include advanced drug delivery systems, solubility enhancement technologies, amorphous solid dispersions, particle engineering, pharmaceutical process optimisation, and the translation of innovative formulations from laboratory development to commercial manufacturing. Earlier in his career, he served as a lecturer in pharmaceutics at universities in the United Kingdom.

An internationally recognised scientist, Dr. Rudrangi is a Fellow of the Royal Society of Chemistry (FRSC), a Chartered Chemist (CChem), and a Chartered Scientist (CSci). He is an active member of several leading international scientific and professional organisations. His professional recognition includes the Royal Society of Chemistry Inspirational Committee Award and the Best Young Researcher Forum Award at the World Drug Delivery Summit (USA). He has also served as Conference Chair for multiple Royal Society of Chemistry Formulation Science & Technology Group conferences, fostering scientific collaboration and innovation within the global pharmaceutical community.

Vinay Jain has always been astounded by the medicinal properties that plants possess. To use them in the welfare of mankind has always been there in his contemplation until his graduation (2002), which he completed from SOS, Pharmacy from Jiwaji University, Gwalior. This motivated him to select Pharmacognosy as one of his subjects in Major. He completed M. Pharm (2007) in Pharmacognosy from Barkatullah University Bhopal. Having completed his postgraduation, he started exploring phytochemicals in his professional journey as Assistant Professor in ShriRam College of Pharmacy, Banmore. Concurrently, he got a chance to be part of the training & placement team. This developed his soft skills to a large extent. He successfully defended his thesis entitled "Phytochemical and Pharmacological investigation of Arisaema leschenaultii" for Ph. D. He was awarded Ph. D in Pharmaceutical science and technology from Berhampur University, Odisha. He was Co-convener of Indo-Caribbean conference which was hosted by Shri Ram College of Pharmacy in 2018. He was also the organising secretary of national conference on "The Future Prospect in Pharma Marketing" hosted in association with IPGA. Till date, he has guided more than 20 undergraduate and post graduate students in major projects. His CV today hosts about 30 papers which have been published in distinguished journals/books of international and national repute which are indexed in SCI and SCOPUS. He has presented more than 20 papers in national and international seminars and conferences. He was also privileged to get grants from technical professional bodies like AICTE and MPCST for organising conferences. He is a life time member of Indian Society of Pharmacognosy. He always tries to keep his staff highly motivated with his open-door policy for grievance redressal and with efficient leadership skills because he believes that only a highly motivated team creates a highly efficient institution.

Pankaj Sharma 是印度中央邦 Morena 的 Banmore ShriRam College of Pharmacy 藥劑學教授兼系主任，在藥學領域擁有超過 14 年的教學與研究經驗。他於 Gwalior 的 Jiwaji University 取得藥學博士學位，博士研究著重於開發以奈米乳劑為基礎、用於瘧疾治療的經皮藥物遞送系統。他亦持有藥劑學 M.Pharm 學位，並獲得 AICTE-GPAT fellowship 支持。

Sharma 博士的研究興趣涵蓋奈米醫學、智慧型聚合物、經皮與標靶藥物遞送系統、藥物奈米毒理學、醫療領域的人工智慧，以及先進製劑開發。他透過 60 多篇經同儕審查的出版品對學術界作出重要貢獻，其中包括發表於 Scopus 與 Web of Science 收錄期刊的論文，以及由國際主要出版社出版的多部書籍章節。

他是多部國際書籍的編者／作者，相關著作已由 CRC Press、Elsevier、Apple Academic Press（Taylor & Francis）及 Bentham Science 出版或獲接受出版；同時積極投入奈米科技、AI 與個人化醫療交會領域的跨學科研究。Sharma 博士亦是獲認可的 M.Pharm 指導教授，並已成功指導多項研究所研究計畫。

為表彰其學術成就，他曾獲 Indian Pharma Educational Society 頒發「最佳博士獎」（Best Doctorate Award），並擁有一項智慧型藥品監測系統的英國設計專利。他對教學、研究指導與創新的投入，持續支持藥學教育與轉譯研究的發展。

Shashi Ravi Suman Rudrangi 是一名特許科學家（Chartered Scientist）及資深藥學領導者，擁有超過 14 年的國際經驗，涵蓋製劑研究與開發、製造科學與技術（Manufacturing Science and Technology, MSAT）、端到端化學、製造與管制（Chemistry, Manufacturing and Controls, CMC）策略，以及口服固體劑型產品的商業化。目前他任職於愛爾蘭都柏林的 Olema Oncology，擔任 CMC 藥品製造副主任（Associate Director, CMC Drug Product Manufacturing），負責領導支援創新腫瘤治療藥物開發與商業化的策略性 CMC 製造活動。

加入 Olema Oncology 前，Rudrangi 博士曾於英國與愛爾蘭的 Kent-Athlone Pharma Group 擔任資深藥品開發與商業化經理（技術主管）（Senior Drug Product Development and Commercialisation Manager, Technical Head），領導負責口服固體劑型配方開發與放大試驗的跨學科團隊。在其職業生涯中，他曾主導複雜的技術移轉計畫，並協助藥品在多個歐洲市場成功商業上市。他的專長包括配方與製程開發、品質源於設計（Quality by Design, QbD）、製程確效、GMP 製造，以及產品生命週期管理。

Rudrangi 博士於英國 Greenwich University 取得藥劑學博士學位及配方科學碩士學位，並於印度 Kakatiya University 取得藥學學士學位。他的研究興趣包括先進藥物遞送系統、溶解度提升技術、非晶態固體分散體、粒子工程、藥物製程最佳化，以及將創新配方從實驗室開發轉化至商業製造。在職涯早期，他曾於英國多所大學擔任藥劑學講師。

Rudrangi 博士是國際知名科學家，身為 Royal Society of Chemistry Fellow（FRSC）、特許化學家（Chartered Chemist, CChem）及特許科學家（Chartered Scientist, CSci），並積極參與多個國際領先的科學與專業組織。他曾獲 Royal Society of Chemistry Inspirational Committee Award，以及在 World Drug Delivery Summit（美國）獲頒 Best Young Researcher Forum Award。他也曾擔任多場 Royal Society of Chemistry Formulation Science & Technology Group 會議的會議主席，促進全球藥學社群中的科學合作與創新。

Vinay Jain 一直對植物所具有的藥用特性深感驚嘆。自求學期間起，他便持續思考如何運用這些特性造福人類；他於 2002 年畢業於 Gwalior 的 Jiwaji University，取得 SOS, Pharmacy 學位。這促使他在主修課程中選擇藥用植物學（Pharmacognosy）作為學習科目之一。2007 年，他於 Bhopal 的 Barkatullah University 取得藥用植物學 M.Pharm 學位。

完成研究所學業後，他在 Banmore 的 ShriRam College of Pharmacy 擔任助理教授，開始於職業生涯中探索植物化學成分（phytochemicals）。同時，他也有機會成為訓練與就業安置團隊的一員，這大幅培養了他的軟實力。他成功為題為「Arisaema leschenaultii 的植物化學與藥理學研究」（Phytochemical and Pharmacological Investigation of Arisaema leschenaultii）的論文進行口試答辯，並於 Odisha 的 Berhampur University 取得藥學科學與技術博士學位。

2018 年，他擔任由 Shri Ram College of Pharmacy 主辦之 Indo-Caribbean conference 的共同召集人。他亦曾擔任與 IPGA 合作主辦的全國性會議「藥品行銷的未來展望」（The Future Prospect in Pharma Marketing）的籌備秘書。截至目前，他已指導超過 20 名大學部與研究所學生完成專題研究。他目前的學術履歷包括約 30 篇論文，發表於國際與印度國內享有聲譽、並收錄於 SCI 與 SCOPUS 的優良期刊及書籍中。他曾在國內外研討會與會議發表超過 20 篇論文。

此外，他也曾獲得 AICTE 與 MPCST 等技術專業機構提供的經費補助，用於舉辦會議。他是 Indian Society of Pharmacognosy 的終身會員。他始終透過開放式管理政策處理教職員的問題，並運用有效的領導能力，努力維持團隊高度的工作動力，因為他相信，只有高度投入的團隊，才能建立高效率的機構。