Pharmaceutical Biotechnology: Integrating Genomics and Emerging Technologies in Modern Drug Development
暫譯: 藥物生物技術：整合基因組學與新興技術於現代藥物開發

這本書探討了藥物生物技術在現代藥物開發中的角色，突顯了基因組學、生物製藥和個人化醫療的最新進展。它探索了正在革新藥物發現、設計和交付的關鍵分子和基因組技術。導言章節描述了基本的分子生物學技術，包括下一代定序（next-generation sequencing）和CRISPR應用、基因編輯、合成生物學及其在藥物發現中的角色。此外，本書探討了藥物基因組學（pharmacogenomics）作為基因組學與藥物反應之間的聯繫，同時涵蓋了生物製藥的發現、生產和商業化。它深入討論了生物信息學在分析基因組數據以進行藥物開發中的角色，以及針對目標識別、驗證和發現對現代藥物開發至關重要的生物標記的基因組策略。本書還突顯了個人化醫療的進展，強調利用基因組數據為個別患者量身定制治療。它討論了單克隆抗體的設計和治療應用，並探索了細胞和基因療法的突破，針對其潛力及與疾病治療相關的挑戰進行探討。

主要特點：
- 提供藥物生物技術和基因組學的歷史和技術視角
- 探索先進的分子技術，包括CRISPR和下一代定序及其在藥物發現中的應用
- 討論藥物基因組學及生物標記在實現個人化醫療中的角色
- 突顯合成生物學、基因編輯和生物製藥開發等新興趨勢
- 處理基因組研究和藥物開發中的倫理問題和挑戰

本書旨在為藥物科學和生物技術的研究人員和學生提供參考。

本書的開放存取版本可在 http://www.taylorfrancis.com 獲得，並已根據創用CC [署名-非商業性-禁止改作 (CC-BY-NC-ND)] 4.0 授權條款提供。

Dr. Arshad Farid, currently serving as an Assistant Professor at Gomal Center of Biochemistry and Biotechnology, Gomal University, D.I.Khan, Pakistan. He has around seventeen years of teaching and research experience. He has supervised seventeen M.Phil. research students and are mentoring several Ph.D. candidates. He has more than 100+ publications of International and National repute. The total cumulative Impact Factor of his published papers is more than 500+. His scientific activities are highly interdisciplinary, ranging from Medicinal Plants; Natural Product Chemistry; Herbal Drug Development; Ethnopharmacology to Nanotechnology, Drug delivery and Microbiology. He has served as editor for seven books that have been accepted for publication. He has also written more than 60 book chapters in Elsevier, Springer, Apple Academic Press and Wiley Publishers etc. He holds a notable count of 27 international patents (Germany, UK, Japan and South African etc.). Moreover, he has published more than 15 abstracts in national and international conference proceedings. He's contributed significantly to the scientific community by peer reviewing papers for more than 30 esteemed journals of MDPI, Elsevier, Springer and Wiley etc. Dr. Arshad was a fellow of the British Council-Charles Wallace Fellowship program at the University of Aberdeen, Scotland, UK, in 2023. Previously, he received a fellowship for "Training in the Environmental, Agricultural, and Analytical Chemistry Laboratory Techniques" from the Department of Chemistry, University of Glasgow, Scotland, UK, in 2007. He is also a Research Fellow of INTI International University, Malaysia, from 01 June 2023 to 31 December 2025.

Dr Kifayat Ullah Shah completed his PhD in Pharmaceutics from Universiti Teknologi MARA (UiTM), Malaysia in 2017. He is currently an Assistant Professor and Head of the "Particle Design and Drug Delivery Laboratory" at the Faculty of Pharmacy, Gomal University, D.I. Khan, Pakistan, with approximately sixteen years of teaching and research experience. He is active researcher in the field of particle design and drug delivery. Dr. Shah has successfully supervised 12 Master's and 4 PhD research students. He has published 40 articles in well-reputed journals and contributed several book chapters with various renowned publishers. Dr. Shah, has completed a research project titled "Novel Particulate Carrier Designs for Pulmonary Delivery of Anti-Tubercular Drugs" and has made significant contributions to the scientific community by peer-reviewing papers for many esteemed journals.

Dr. Midrarullah is an experienced academic and researcher, with over 19 years of teaching and research experience. He is currently serving as an Associate Professor in the Department of Biotechnology at Shaheed Benazir Bhutto University (SBBU), Pakistan. Dr. Midrarullah holds a PhD in Plant Biotechnology from the University of Peshawar, as well as an MPhil in the same field from Quaid-i-Azam University. Dr. Midrarullah's academic career is distinguished by his leadership in both teaching and administration. He has served in various key roles, including Chairman of the Biotechnology Department, Director of Advance Studies & Research, and Registrar of the University. He has also contributed significantly to the strategic planning and development of the university, including his leadership in committees related to admissions, curriculum development, and faculty management. In addition to his academic and administrative roles, Dr. Midrarullah has been deeply involved in research, with numerous publications in the field of Plant Biotechnology. His research has focused on topics related to sustainable agriculture, biotechnology applications in plant breeding, and environmental conservation. Dr. Midrarullah has supervised several MPhil and PhD students, contributing to the next generation of researchers and academics in biotechnology. He was honored with the Best University Teacher Award by the Higher Education Commission of Pakistan in 2015, and he has been nominated by both the British Council of Pakistan and the Ministry of Climate Change as a speaker at various international forums. His involvement in global training programs and conferences, including those in the United Kingdom, South Korea, and Iran, reflects his commitment to continuing professional development and fostering international collaboration.

Dr Gagan Preet has been serving as a Teaching Research Fellow at the Marine Biodiscovery Research Centre, University of Aberdeen, Aberdeen, Scotland, UK, since 2019. He is an expert in marine natural products research, with a strong background in chemistry and specialized expertise in computational chemistry relevant to drug design and discovery. In April 2023, Dr Preet was awarded a Postdoctoral Research Fellowship at the Marine Biodiscovery Centre, University of Aberdeen, UK. He collaborates with the National History Museum, the National Oceanography Centre, the University of South Pacific, and other institutions on the DEFRA, UK funded project DEEPEND. This project focuses on understanding the impacts of climate change and seabed mining on the ecology, microbiology, and chemistry of deep-sea biodiversity. Dr. Preet's role involves coordinating research efforts, compiling comprehensive chemical data on deep-sea biodiversity, and mapping this information. Additionally, Dr Preet's research includes the discovery of new molecules to target the Dengue Virus (a neglected tropical disease), Mucormycosis, and Type 2 Diabetes using computational and chemoinformatics approaches. He collaborates with other scientific laboratories to perform in vitro tests on the identified leads. Dr Preet's extensive laboratory research experience is invaluable in training PhD students and early-career researchers. His primary objective in academia is to actively engage in knowledge transfer and human capacity development through teaching, training, and mentoring students, fostering their development into excellent researchers, and continuously contributing to scientific knowledge with impactful and relevant outputs.

阿爾沙德·法里德博士目前擔任巴基斯坦D.I.Khan的戈馬爾大學生物化學與生物技術中心的助理教授。他擁有約十七年的教學和研究經驗，已指導十七名碩士研究生，並且正在指導多名博士候選人。他的國內外出版物超過100篇，累計影響因子超過500。他的科學活動涵蓋多個學科，包括藥用植物、天然產品化學、草藥藥物開發、民族藥理學、納米技術、藥物傳遞和微生物學。他擔任過七本已接受出版的書籍的編輯，並在Elsevier、Springer、Apple Academic Press和Wiley等出版社撰寫了超過60章書籍。他擁有27項國際專利（德國、英國、日本和南非等）。此外，他在國內外會議論文集中發表了超過15篇摘要。他為MDPI、Elsevier、Springer和Wiley等30多本知名期刊進行同行評審，對科學社群做出了重要貢獻。阿爾沙德博士於2023年成為英國阿伯丁大學英國文化協會-查爾斯·華萊士獎學金計劃的研究員。此前，他於2007年獲得英國格拉斯哥大學化學系的「環境、農業和分析化學實驗室技術培訓」獎學金。他也是馬來西亞INTI國際大學的研究員，任期從2023年6月1日至2025年12月31日。

基法亞特·烏拉·沙博士於2017年在馬來西亞的馬來亞科技大學（UiTM）獲得藥劑學博士學位。他目前是巴基斯坦D.I. Khan的戈馬爾大學藥學院的助理教授及「顆粒設計與藥物傳遞實驗室」的負責人，擁有約十六年的教學和研究經驗。他在顆粒設計和藥物傳遞領域積極從事研究。沙博士成功指導了12名碩士和4名博士研究生。他在知名期刊上發表了40篇文章，並與多家知名出版社合作撰寫了幾章書籍。沙博士完成了一個名為「抗結核藥物的肺部傳遞新型顆粒載體設計」的研究項目，並通過為多本知名期刊進行同行評審，對科學社群做出了重要貢獻。

米德拉魯拉博士是一位經驗豐富的學者和研究人員，擁有超過19年的教學和研究經驗。他目前擔任巴基斯坦沙希德·貝納齊爾·布托大學（SBBU）生物技術系的副教授。米德拉魯拉博士擁有來自佩什瓦爾大學的植物生物技術博士學位，以及來自奎德·阿扎姆大學的同領域碩士學位。他的學術生涯因在教學和行政管理方面的領導而卓越，曾擔任生物技術系主任、高級研究與研究主任及大學註冊主任等多個重要職位。他在大學的戰略規劃和發展方面也做出了重要貢獻，包括在招生、課程開發和教職員管理相關委員會中的領導角色。除了學術和行政職位外，米德拉魯拉博士在植物生物技術領域的研究也非常活躍，發表了多篇相關論文。他的研究重點包括可持續農業、生物技術在植物育種中的應用以及環境保護。米德拉魯拉博士指導了多名碩士和博士生，為下一代生物技術研究人員和學者做出了貢獻。他於2015年獲得巴基斯坦高等教育委員會頒發的最佳大學教師獎，並被巴基斯坦英國文化協會和氣候變化部提名為多個國際論壇的演講者。他參與的全球培訓計劃和會議，包括在英國、南韓和伊朗的活動，反映了他對持續專業發展和促進國際合作的承諾。

加根·普里特博士自2019年以來一直擔任英國阿伯丁大學海洋生物發現研究中心的教學研究員。他是海洋天然產品研究的專家，擁有化學背景，並在與藥物設計和發現相關的計算化學方面具有專業知識。2023年4月，普里特博士獲得了英國阿伯丁大學海洋生物發現中心的博士後研究獎學金。他與國家歷史博物館、國家海洋中心、南太平洋大學及其他機構合作，參與DEFRA資助的DEEPEND項目。該項目專注於了解氣候變化和海床採礦對深海生物多樣性的生態學、微生物學和化學的影響。普里特博士的角色包括協調研究工作、編纂深海生物多樣性的綜合化學數據並繪製這些信息。此外，普里特博士的研究還包括使用計算和化學信息學方法發現針對登革熱病毒（被忽視的熱帶疾病）、毛黴病和2型糖尿病的新分子。他與其他科學實驗室合作，對已識別的潛在藥物進行體外測試。普里特博士在實驗室研究方面的豐富經驗對於培訓博士生和早期職業研究人員至關重要。他在學術界的主要目標是通過教學、培訓和指導學生，積極參與知識轉移和人力資源開發，促進他們成為優秀的研究人員，並持續以有影響力和相關的成果貢獻科學知識。