Model-Oriented Design of Experiments
暫譯: 模型導向的實驗設計

Fedorov, Valerii V., Hackl, Peter

Model-Oriented Design of Experiments

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商品描述

This book presents the basic ideas of statistical methods in the design of optimal experiments. This new edition now includes sections on design techniques based on the elemental Fisher information matrices (as opposed to Pearson information/moment matrices), allowing a seamless extension of the design techniques to inferential problems where the shape of distributions is essential for optimal design construction. Topics include designs for nonlinear models, models with random parameters and models with correlated observations, designs for model discrimination and misspecified (contaminated) models, and designs in functional spaces.

The authors avoid technical details, assuming a moderate background in calculus, matrix algebra, and statistics. In many places, however, suggestions are made as to how the ideas presented in this book can be extended and elaborated for use in real scientific research and practical engineering problems.

商品描述(中文翻譯)

本書介紹了在最佳實驗設計中統計方法的基本概念。這一新版現在包含了基於基本 Fisher 資訊矩陣的設計技術部分（與 Pearson 資訊/矩陣不同），使得設計技術能夠無縫擴展到推論問題中，這些問題中分佈的形狀對於最佳設計構建至關重要。主題包括非線性模型的設計、隨機參數模型和相關觀察模型的設計、模型區分的設計以及錯誤指定（污染）模型的設計，還有在函數空間中的設計。

作者避免了技術細節，假設讀者具備中等程度的微積分、矩陣代數和統計學背景。然而，在許多地方，書中提出了如何將這些概念擴展和詳細說明，以便用於實際的科學研究和工程問題的建議。

作者簡介

Valerii V. Fedorov is an independent consultant. During the last two decades, he has been involved in the development of optimal design methods for pharmaceutical research; he was Vice President, Innovation Center, ICON plc; Vice President and Head of Predictive Analytics, Quintiles; Head of the Research Statistics Unit, GlaxoSmithKline inc. Professor Fedorov is the author of over 200 publications, including several books. His monograph The Theory of Optimal Experiments (1972, Academic Press) is one of the first books on optimal experimental design; his Optimal Design for Nonlinear Response Models (co-authored with Dr. Sergei Leonov, 2014, CRC) describes methods developed for pharmaceutical research. Valerii is an ASA Fellow, an Honorary Professor of Cardiff University, UK, an Adjunct Scholar of the University of Pennsylvania, USA, and an elected member and former Council member of the International Statistical Institute.

Peter Hackl, born in Linz, Austria, is Professor of Statistics at the Vienna University of Economics and Business. He is an internationally recognized expert in statistical methods and applications and has published on topics such as time series analysis, econometric methods, optimal design of experiments, as well as for statistical methods for process control, quality improvement, and customer satisfaction measurement. He is the author of five books, editor of two, and has published more than 120 articles in refereed scientific journals.

作者簡介(中文翻譯)

瓦列里·V·費多羅夫（Valerii V. Fedorov）是一位獨立顧問。在過去的二十年中，他參與了藥物研究的最佳設計方法的開發；曾擔任ICON plc創新中心的副總裁；Quintiles的副總裁及預測分析部門負責人；以及葛蘭素史克（GlaxoSmithKline Inc.）研究統計單位的負責人。費多羅夫教授是200多篇出版物的作者，包括幾本書籍。他的專著《最佳實驗理論》（The Theory of Optimal Experiments，1972年，Academic Press）是關於最佳實驗設計的首批書籍之一；他的《非線性響應模型的最佳設計》（Optimal Design for Nonlinear Response Models，與謝爾蓋·列昂諾夫（Dr. Sergei Leonov）合著，2014年，CRC）描述了為藥物研究開發的方法。瓦列里是美國統計協會（ASA）會士，英國卡迪夫大學的榮譽教授，美國賓夕法尼亞大學的兼任學者，以及國際統計學會的當選成員和前理事會成員。

彼得·哈克爾（Peter Hackl）出生於奧地利林茨，是維也納經濟與商業大學的統計學教授。他是統計方法和應用的國際公認專家，發表過有關時間序列分析、計量經濟學方法、實驗的最佳設計，以及過程控制、質量改進和顧客滿意度測量的統計方法等主題的文章。他是五本書的作者，兩本書的編輯，並在經過審核的科學期刊上發表了超過120篇文章。

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