Precision Cancer Therapies, Immunologic Approaches for the Treatment of Lymphoid Malignancies: From Concept to Practice

O'Connor, Owen A., Ansell, Stephen M., Gribben, John G.

  • 出版商: Wiley
  • 出版日期: 2024-02-12
  • 售價: $7,020
  • 貴賓價: 9.5$6,669
  • 語言: 英文
  • 頁數: 496
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 1119824540
  • ISBN-13: 9781119824541
  • 海外代購書籍(需單獨結帳)

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商品描述

Presents timely and authoritative information on the development of precision cancer therapies as applied to hematologic malignancies

The Precision Cancer Therapies series focuses on how to understand and translate fundamental basic science into information that can be directly applied to patients to advance care. Each volume of the series integrates the relevant biological concepts and principles necessary for translating this science to practitioners of this science.

Precision Cancer Therapies, Volume Two, focuses on sophisticated immunotherapies targeting cancers affecting the blood, bone marrow, and lymph nodes. Edited and authored by the foremost authorities in the field, this comprehensive reference text covers targeting of cell surface receptors, antibody-drug conjugates (ADC), targeting immune checkpoint, targeting macrophages, EBV-directed immunotherapies, tumor-associated antigens (TAA), and chimeric antigen receptor T-cells (CAR-T).

Divided into nine sections, Volume Two includes an overview of the history of immunotherapy development in cancer, as well as a concluding section addressing the mechanistic basis and role of immunomodulatory drugs, analytical tools to quantitate immune-mediated effects, and other topics in immunotherapy. Chapters on specific therapeutics or therapeutic classes include a basic explanation of the underlying pathway and target, the pharmacology of the drug/class, relevant preclinical and clinical data, and discussion of clinical management and potential predictive biomarkers of response. This book also:

  • Delivers a definitive, state-of-the-art review of the relevant biology and its importance in the broader context of cancer biology
  • Focuses on agents that mediate cell killing in lymphoma through a variety of immunologic mechanisms
  • Covers FDA-approved drugs and their indications, as well as drugs currently in development
  • Provides information on monotherapy and combination therapy, summary tables of trials, and discussion of toxicity and efficacy
  • Includes boxed sections highlighting major unique points about the information in the chapter

Precision Cancer Therapies, Volume Two: Immunologic Approaches for the Treatment of Lymphoid Malignancies, From Concept to Practice is an indispensable resource for medical, scientific, and allied medical professionals, advanced students, and interested general readers with background knowledge in the subject.

商品描述(中文翻譯)

「精準癌症治療」系列提供了關於精準癌症治療在血液惡性腫瘤中的發展的及時和權威資訊。該系列著重於如何理解和轉化基礎科學,以便直接應用於患者,推進護理。該系列的每一卷都整合了相關的生物概念和原則,這對於將這一科學轉化為實踐者來說是必要的。

「精準癌症治療,第二卷」專注於針對影響血液、骨髓和淋巴結的癌症的先進免疫療法。由該領域的頂尖專家編輯和撰寫的這本綜合性參考書涵蓋了針對細胞表面受體的靶向治療、抗體藥物載體(ADC)、靶向免疫檢查點、靶向巨噬細胞、EBV導向的免疫療法、腫瘤相關抗原(TAA)和嵌合抗原受體T細胞(CAR-T)。

「第二卷」分為九個部分,包括免疫療法在癌症治療中的發展歷史概述,以及一個結尾部分,討論免疫調節藥物的機制基礎和作用、分析工具以量化免疫介導效應以及免疫療法中的其他主題。關於特定治療劑或治療類別的章節包括對潛在途徑和靶點的基本解釋,藥物/類別的藥理學,相關的臨床前和臨床數據,以及對臨床管理和潛在預測性反應生物標記的討論。

本書還包括以下內容:
- 提供了有關相關生物學及其在癌症生物學更廣泛背景中的重要性的明確、最新的綜述
- 專注於通過多種免疫機制在淋巴瘤中介導細胞殺傷的藥物
- 包括FDA批准的藥物及其適應症,以及目前正在開發中的藥物
- 提供有關單一療法和聯合療法的信息,試驗的摘要表格,以及有關毒性和療效的討論
- 包括突出顯示章節信息的方框部分

「精準癌症治療,第二卷:淋巴惡性腫瘤的免疫治療方法,從概念到實踐」是醫學、科學和醫學相關專業人士、高級學生以及對該主題有背景知識的一般讀者的不可或缺的資源。

作者簡介

OWEN A. O'CONNOR, MD, PhD, American Cancer Society Research Professor; Professor of Medicine, University of Virginia Cancer Center, Charlottesville, VA, USA.

STEPHEN M. ANSELL, MD, PhD, Consultant, Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

JOHN G. GRIBBEN, MD, DSc, Hamilton-Fairley Chair of Medical Oncology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, UK.

作者簡介(中文翻譯)

OWEN A. O'CONNOR, MD, PhD,美國癌症協會研究教授;維吉尼亞大學癌症中心醫學教授,位於美國弗吉尼亞州夏洛茨維爾。

STEPHEN M. ANSELL, MD, PhD,內科醫學部血液學科顧問,位於美國明尼蘇達州羅徹斯特的梅奧診所。

JOHN G. GRIBBEN, MD, DSc,醫學腫瘤學哈密爾頓-費爾利主席,位於英國倫敦瑪麗女王大學巴茨癌症研究所的血液腫瘤學中心。