Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques
暫譯: 液相層析與相關分離技術的帶電氣溶膠檢測
Acworth, Ian N., Gamache, Paul H.
- 出版商: Wiley
- 出版日期: 2026-10-26
- 售價: $5,710
- 貴賓價: 9.5 折 $5,424
- 語言: 英文
- 頁數: 464
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 1394300603
- ISBN-13: 9781394300600
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相關分類:
化學 Chemistry
尚未上市，無法訂購
相關主題
商品描述
Updated CAD reference covering theory, optimization, and emerging applications
Charged aerosol detection offers analyte-independent response that overcomes limitations of UV detection, yet its fundamental performance characteristics remain incompletely understood. Now in its Second Edition, Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques consolidates current theoretical and practical knowledge of CAD into a single authoritative source, covering theory, experimental techniques, and end-user applications for liquid phase separations.
New to this edition is coverage of RNA-lipid nanoparticle-based vaccines for SARS-CoV-2 and polysorbate analysis in biopharmaceuticals, reflecting CAD's rapid adoption in pharmaceutical and biopharmaceutical laboratories. The book details proper use and optimization of the CAD detector, emphasizing fundamentals alongside real-world application across biochemical, environmental, food and beverage, and chemical industry contexts.
Readers will also find:
- Detailed discussion of CAD response characteristics including chemical scope, dynamic range, reproducibility, and sensitivity compared to other universal detectors
- Guidance on integrating CAD with UHPLC, novel stationary phases, and multi-dimensional separation workflows for enhanced analytical performance
- Practical examples illustrating CAD optimization strategies tailored to specific analyte classes and separation conditions across diverse laboratory settings
- Coverage of aerosol technology fundamentals that underpin charged aerosol detection, drawn from experts in aerosol science and separation sciences
- Analysis of CAD advantages over optical detection methods for analytes lacking strong chromophores or consistent ultraviolet absorption properties
This Second Edition serves scientists utilizing chromatographic techniques across academic, biopharmaceutical, biotechnology, biofuel, chemical, environmental, food and beverage, and pharmaceutical industries. It provides practicing chemists and researchers with the consolidated reference needed to implement and optimize CAD in their analytical workflows.
商品描述(中文翻譯)
更新版 CAD 參考書，涵蓋理論、最佳化與新興應用
帶電氣溶膠偵測（charged aerosol detection, CAD）能提供與分析物無關的響應，克服紫外線偵測的限制；然而，其基本性能特徵目前仍未獲得完整理解。第二版《液相層析與相關分離技術的帶電氣溶膠偵測》將 CAD 的現代理論與實務知識整合於單一權威參考來源，涵蓋液相分離的理論、實驗技術與終端使用者應用。
本版新增 SARS-CoV-2 的 RNA－脂質奈米粒子疫苗，以及生物製藥中的 polysorbate 分析，反映 CAD 在製藥與生物製藥實驗室中的快速普及。本書詳細說明 CAD 偵測器的正確使用方式與最佳化方法，除強調基礎原理外，也涵蓋其在生化、環境、食品與飲料，以及化學工業領域中的實際應用。
讀者還可以了解：
• 詳細討論 CAD 的響應特性，包括化學適用範圍、動態範圍、再現性，以及相較於其他通用型偵測器的靈敏度
• 說明如何將 CAD 整合至 UHPLC、新型固定相與多維分離工作流程，以提升分析性能
• 透過實務範例，說明如何針對不同分析物類別、分離條件與多元實驗室環境，制定 CAD 最佳化策略
• 涵蓋帶電氣溶膠偵測所依據的氣溶膠技術基礎，內容由氣溶膠科學與分離科學領域的專家共同提供
• 分析 CAD 相較於光學偵測方法的優勢，尤其適用於缺乏強發色團或無法穩定吸收紫外線的分析物
本第二版適合在學術、生物製藥、生物技術、生質燃料、化學、環境、食品與飲料，以及製藥產業中使用層析技術的科學家。本書為實務化學家與研究人員提供整合式參考資料，協助他們在分析工作流程中導入並最佳化 CAD。
作者簡介
IAN N. ACWORTH, DPhil, is a specialist supporting the Thermo Fisher chromatography marketing department with a focus on charged aerosol detection. He brings over 30 years of experience in the analytical industry, contributing deep knowledge of CAD technology and its practical applications across pharmaceutical, biopharmaceutical, and related scientific fields.
PAUL H. GAMACHE is an independent consultant specializing in universal detection for liquid chromatography. He has worked for more than 40 years within the analytical instrument industry, serving various roles in both R&D and applications development, with a career focused predominantly on chromatographic techniques.
作者簡介(中文翻譯)
IAN N. ACWORTH，DPhil，是一名專家，支援 Thermo Fisher 的 chromatography 行銷部門，專注於帶電氣溶膠偵測（charged aerosol detection）。他在分析產業擁有超過 30 年的經驗，具備深厚的 CAD 技術及其實際應用知識，涵蓋製藥、生物製藥及相關科學領域。
PAUL H. GAMACHE 是一名獨立顧問，專精於液相層析的通用型偵測（universal detection）。他在分析儀器產業服務超過 40 年，曾擔任研發與應用開發等各類職務，職涯主要專注於層析技術。
