Cellular and Molecular Mechanisms in Alzheimer"s Disease Therapeutics: Volume 1: Cellular Mechanisms
暫譯: 阿茲海默症治療中的細胞與分子機制：第一卷：細胞機制

阿茲海默症（AD）是一個深刻且日益嚴重的全球健康問題，其特徵為逐漸的神經退行性變化和認知衰退。隨著對阿茲海默症潛在成因的研究不斷深入，越來越明顯的是，對其分子機制的深入理解對於開發有效的治療干預至關重要。本套新書《阿茲海默症治療中的細胞與分子機制》分為兩卷，詳細探討了驅動阿茲海默症發病和進展的細胞與分子過程。這兩卷書匯集了領域內的專家，提供了對於阿茲海默症病理中複雜的細胞與分子途徑的見解，以及潛在的治療靶點和創新的治療策略。

《第一卷：阿茲海默症治療中的細胞機制》提供了對於阿茲海默症中涉及的細胞過程的詳細且最新的探討，重點在於這些過程對治療干預的影響。本書全面理解了各種細胞機制如何影響疾病病理，例如突觸功能障礙、神經炎症、線粒體損傷和蛋白質聚集等。主題包括阿茲海默症中的血腦屏障功能障礙、基於基因剖析的個性化醫療方法、微小RNA在疾病管理中的作用等。

《第二卷：阿茲海默症治療中的分子機制》提供了對於疾病在分子層面的全面理解，涵蓋了淀粉樣β蛋白和tau蛋白的錯誤摺疊與聚集、細胞穩態的破壞、線粒體功能障礙和神經炎症等問題。本卷介紹了一些新興工具和新型治療方法，並討論了神經退行性疾病的藥理調節、行為干預和認知訓練在阿茲海默症管理中的應用、根據個體的基因和分子特徵定制治療、臨床試驗和研究中的倫理考量、國際間在阿茲海默症研究和治療方面的努力等。本卷彌合了分子研究與治療應用之間的鴻溝，揭示了與疾病機制相關的最新發現，如氧化壓力、突觸變化和神經炎症途徑的角色。

與其他文本不同，這兩卷書整合了最新的生物標記、藥物開發和創新治療策略的研究，提供了一個全面且最新的資源。對於基礎科學和實用治療應用的獨特關注，使這套兩卷書成為研究人員、臨床醫生和學生在推進對疾病的理解和治療方面的寶貴指南。通過聚焦於這種疾病的細胞和分子見解，這些卷書為激發針對神經退行性變化根本原因的新型治療方法鋪平了道路。

Prashant Tiwari, PhD, is an Associate Professor in the Department of Pharmacology at the College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, India. He has over a decade of experience in the field of teaching and research related to pharmacology. His expertise includes drug screening, method validation for brain-targeted drug delivery, drug-induced dyskinesia revalidation, and the neuroprotective effects of benzimidazole derivatives. His research has explored the dopaminergic pathway, prolactin inhibition, and neuroprotection, with notable studies on nanoemulsions containing Lepidium sativum oil for Parkinson's disease and Muntingia calabura leaf extract for Alzheimer's disease. For his outstanding work, Dr. Tiwari received the Dr. P. D. Patil National Award for Best Thesis in Pharmaceutical Sciences (2022). In addition to his research, Dr. Tiwari has authored five books, edited five books, and co-authored six book chapters. He has filed seven patents, two of which have been granted. He organized a national e-seminar on targeted drug delivery against neurodegenerative diseases, sponsored by the Department of Biotechnology (DBT), Government of India. Dr. Tiwari has been honored with various awards as well. He supervises five PhD students and has guided nine MPharm students. He is also an active member of professional bodies and serves as a peer reviewer for international journals. His research interests span neurodegenerative disorders, drug interactions, pharmacokinetics/pharmacodynamics, and metabolic disorders. He holds a PhD from Siksha O Anusandhan University, Bhubaneswar, and was a fellow of the Indian Council of Medical Research (ICMR), New Delhi, India.

Sunil Kumar Kadiri, PhD, is currently working as a Professor in the College of Pharmaceutical Sciences at Dayananda Sagar University, Bengaluru, Karnataka, India. He has 16 years of experience in teaching. His area of interest is neuropharmacology and drug interactions. He has over 50 research and review publications to his credit as well as four books and three patents. He is a professional member of the Association of Pharmaceutical Teachers of India. Dr. Kadiri completed his PhD in Pharmaceutical Sciences at JNTU Hyderabad, Telangana, India.

Kunjbihari Sulakhiya, PhD, is working as an Assistant Professor at the Department of Pharmacy, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh, India. He has published over 20 research papers, seven review articles, and more than 10 book chapters. He has received 13 awards and fellowships, including six travel awards to present his research papers at international conferences in the USA, Canada, Japan, France, and Macau. He is a member of various professional societies, including the Indian Academy of Neurosciences, the International Society for Neurochemistry, Asia Pacific Society for Neurochemistry, Association of Pharmaceutical Teachers of India, etc. He is serving as an editorial member and reviewer for various reputed journals. His area of research is pre-clinical research in the field of neuropharmacology. He earned his MPharm and PhD in Pharmacology and Toxicology at the National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam, India.

**Prashant Tiwari, PhD**，是印度班加羅爾Dayananda Sagar大學藥學院藥理學系的副教授。他在藥理學相關的教學和研究領域擁有超過十年的經驗。他的專長包括藥物篩選、針對大腦的藥物傳遞方法驗證、藥物引起的運動障礙再驗證，以及苯並咪唑衍生物的神經保護效果。他的研究探討了多巴胺能通路、催乳素抑制和神經保護，並對含有Lepidium sativum油的納米乳劑用於帕金森病以及Muntingia calabura葉提取物用於阿茲海默病進行了顯著研究。因其卓越的工作，Tiwari博士於2022年獲得了Dr. P. D. Patil藥學最佳論文國家獎。除了研究外，Tiwari博士還著作五本書籍，編輯五本書籍，並共同撰寫六個書章。他已申請七項專利，其中兩項已獲得批准。他組織了一場由印度政府生物技術部（DBT）贊助的針對神經退行性疾病的靶向藥物傳遞全國電子研討會。Tiwari博士也獲得了多項獎項。他指導五名博士生，並指導九名碩士生。他還是多個專業機構的活躍成員，並擔任國際期刊的同行評審。他的研究興趣涵蓋神經退行性疾病、藥物相互作用、藥物代謝動力學/藥效學以及代謝疾病。他擁有印度Bhubaneswar的Siksha O Anusandhan大學的博士學位，並曾是印度醫學研究委員會（ICMR）新德里的研究員。

**Sunil Kumar Kadiri, PhD**，目前在印度卡納塔克邦班加羅爾的Dayananda Sagar大學藥學院擔任教授。他擁有16年的教學經驗。他的研究興趣是神經藥理學和藥物相互作用。他擁有超過50篇研究和綜述出版物，以及四本書籍和三項專利。他是印度藥學教師協會的專業成員。Kadiri博士在印度特倫甘納邦的JNTU Hyderabad完成了藥學博士學位。

**Kunjbihari Sulakhiya, PhD**，在印度中央邦Amarkantak的Indira Gandhi國立部落大學藥學系擔任助理教授。他已發表超過20篇研究論文、七篇綜述文章和超過10個書章。他獲得了13項獎項和獎學金，包括六項旅行獎，以在美國、加拿大、日本、法國和澳門的國際會議上發表研究論文。他是多個專業學會的成員，包括印度神經科學學會、國際神經化學學會、亞太神經化學學會、印度藥學教師協會等。他擔任多個知名期刊的編輯成員和評審。他的研究領域是神經藥理學的臨床前研究。他在印度阿薩姆邦的國立藥學教育與研究所（NIPER）獲得藥理學和毒理學的碩士和博士學位。