The Dna, Rna, and Histone Methylomes

Jurga, Stefan, Barciszewski, Jan

  • 出版商: Springer
  • 出版日期: 2019-10-07
  • 售價: $6,640
  • 貴賓價: 9.5$6,308
  • 語言: 英文
  • 頁數: 624
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 3030147916
  • ISBN-13: 9783030147914

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商品描述

This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions.

Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms.

This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.


作者簡介

Prof. Dr. hab. Stefan Jurga,

Adam Mickiewicz University, Nanobiomedical Center,

Poznań, Poland

stjurga@amu.edu.pl

Prof. Dr.hab Jan Barciszewski,

Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznań, Poland and

Adam Mickiewicz University, Nanobiomedical Center, Poznań, Poland

jan.barciszewski@ibch.poznan.pl