The Art of Writing Reasonable Organic Reaction Mechanisms (Paperback)
暫譯: 合理有機反應機制寫作的藝術(平裝本)

Grossman, Robert B.

  • 出版商: Springer
  • 出版日期: 2021-01-08
  • 售價: $2,150
  • 貴賓價: 9.5$2,043
  • 語言: 英文
  • 頁數: 435
  • 裝訂: Quality Paper - also called trade paper
  • ISBN: 3030287351
  • ISBN-13: 9783030287351
  • 相關分類: 工程數學 Engineering-mathematics
  • 海外代購書籍(需單獨結帳)

相關主題

商品描述

Intended for students of intermediate organic chemistry, this text shows how to write a reasonable mechanism for an organic chemical transformation. The discussion is organized by types of mechanisms and the conditions under which the reaction is executed, rather than by the overall reaction as is the case in most textbooks. The treatment emphasizes unifying principles, showing how common mechanisms link seemingly disparate reactions. Each chapter discusses common mechanistic pathways and suggests practical tips for drawing them. Worked problems are included in the discussion of each mechanism, and "common error alerts" are scattered throughout the text to warn readers about pitfalls and misconceptions that bedevil students. Each chapter is capped by a large problem set.

The author has drawn on his own research and the current literature to ensure that appropriate attention is given to topics across the range of modern organic chemistry. The text is unique in its inclusion of a chapter on reactions mediated or catalyzed by transition metals, an area in which mechanistic understanding is now essential. Relatively new topics such as olefin metathesis and cycloaromatization are covered without giving short shrift to more traditional areas such as carbonyl chemistry. The text assumes a basic knowledge of organic chemistry. It can be used either in a formal course or by students working on their own, and will be particularly useful for graduate students studying for qualifying examinations. It will also be useful to students and researchers in biochemistry, pharmacology, and inorganic chemistry.

"This is an excellent and well-presented work.... The author ... has succeeded well in treating the central ideas of reactivity and selectivity in an integrated whole. The clear style of writing, the well chosen examples, and the ... concise summaries of the main points provided at the end of each chapter should enable the reader to easily consolidate what has been learned.... The book is indeed a little work of art."

-- Jens Hartung, Angewandte Chemie International Edition

"I have taught a one-credit course with this book for three years, and, uniformly, the students have rated this book highly for its clarity and for the scope of the problems. ... This book does an excellent job at its stated goal: 'to teach students to come up with reasonable mechanisms for reactions they have never seen before.'"

-- Amy Howell, Synthesis

"I have just finished my first year of graduate studies in organic chemistry at Duke University. I just wanted to let you know how much your book got me through the past year of course work.... When it came to mechanisms, I found the clarity and thoroughness I needed only in your book. It was impressive how you were able to present so much information in a clear and comprehensive manner yet keep the book so manageable in size. In addition to the text, I also was able to benefit from the problems.... Great practice!! The on-line answers are much better than looking up answers by reference.... I am reading it again this summer in preparation for my preliminary exam next spring."

-- David Gooden

商品描述(中文翻譯)

本書針對中級有機化學的學生,展示了如何為有機化學轉化撰寫合理的機制。討論是根據機制類型及反應執行的條件來組織,而不是像大多數教科書那樣根據整體反應來組織。這本書強調統一原則,展示了常見機制如何將看似不相關的反應聯繫起來。每一章都討論了常見的機制路徑,並提供了繪製它們的實用建議。每個機制的討論中都包含了已解決的問題,並在文本中散布了「常見錯誤警示」,以提醒讀者注意困擾學生的陷阱和誤解。每一章的結尾都有一組大型問題集。

作者借鑒了自己的研究和當前文獻,以確保對現代有機化學範疇內的主題給予適當的關注。本書的獨特之處在於包含了一章關於過渡金屬介導或催化的反應,這一領域的機制理解現在已變得至關重要。相對較新的主題如烯烴重排和環狀芳香化也得到了涵蓋,而不會忽視更傳統的領域如羰基化學。本書假設讀者具備基本的有機化學知識。它可以用於正式課程或由學生自行學習,對於準備資格考試的研究生特別有用。對於生物化學、藥理學和無機化學的學生和研究人員也將非常有幫助。

「這是一本出色且呈現良好的作品……作者……成功地將反應性和選擇性的核心思想整合在一起。清晰的寫作風格、精心挑選的例子,以及每章結尾提供的主要要點的簡明總結,應該能夠幫助讀者輕鬆鞏固所學的知識……這本書確實是一件小藝術品。」

-- Jens Hartung,《應用化學國際版》

「我已經用這本書教了一門一學分的課程三年,學生們一致對這本書的清晰度和問題的範圍給予了高度評價……這本書在其所聲明的目標上做得非常出色:『教導學生提出他們從未見過的反應的合理機制。』」

-- Amy Howell,《合成》

「我剛剛完成了在杜克大學的有機化學研究生第一年。我只是想讓你知道,你的書在過去一年的課程學習中幫了我很多……當談到機制時,我發現只有在你的書中找到了我所需的清晰和徹底。你能以清晰且全面的方式呈現如此多的信息,卻又保持書籍的可管理性,這令人印象深刻。除了文本,我還能從問題中受益……很好的練習!!線上答案比查閱參考資料要好得多……我這個夏天會再次閱讀它,以準備明年春天的初試。」

-- David Gooden

作者簡介

​Robert B. Grossman earned his A.B. degree at Princeton University and his Ph.D. at MIT. He then moved from Cambridge, Massachusetts to Cambridge, England for his postdoctoral work. In 1994, he moved from the United Kingdom (UK) to the University of Kentucky (UK), where he has been ever since. At UK, Dr. Grossman maintains an active research program focused on synthetic methodology, target-directed synthesis, and biosynthesis. He is also the creator of ACE Organic, a Web-based organic chemistry homework program. Dr. Grossman has also served two terms as one of the two faculty representatives on the UK Board of Trustees.

 

作者簡介(中文翻譯)

​羅伯特·B·格羅斯曼(Robert B. Grossman)在普林斯頓大學獲得學士學位(A.B.),並在麻省理工學院(MIT)獲得博士學位(Ph.D.)。隨後,他從麻薩諸塞州的劍橋搬到英國劍橋進行博士後研究。1994年,他從英國(UK)搬到肯塔基大學(University of Kentucky, UK),並一直在那裡工作。在肯塔基大學,格羅斯曼博士維持著一個活躍的研究計畫,專注於合成方法學、目標導向合成和生物合成。他也是ACE Organic的創建者,這是一個基於網路的有機化學作業程式。格羅斯曼博士還曾擔任肯塔基大學董事會的兩位教職員代表之一,任期兩屆。