Studies of Epithelial Transporters and Ion Channels: Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 3
暫譯: 上皮運輸蛋白與離子通道研究：健康與疾病中的上皮離子通道與運輸蛋白 - 第三卷

Hamilton, Kirk L., Devor, Daniel C.

Studies of Epithelial Transporters and Ion Channels: Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 3
  • 出版商: Springer
  • 出版日期: 2021-03-05
  • 售價: $5,460
  • 貴賓價: 9.5 折 $5,187
  • 語言: 英文
  • 頁數: 1244
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 3030554538
  • ISBN-13: 9783030554538
  • 相關分類: 生物資訊 Bioinformatics

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商品描述

This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across all epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases.
Its focus lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians

商品描述(中文翻譯)

本書討論了位於各種器官的上皮組織中的獨特離子通道和運輸蛋白，包括腎臟、腸道、胰臟和呼吸道。作者將展示這些通道和運輸蛋白在所有上皮組織中進行跨上皮離子和液體運輸的關鍵角色，以及它們在維持內穩態中的責任。讀者將了解上皮離子運輸的基本原理，包括功能、建模、調控、運輸、結構和藥理學。本書是三卷系列中的第三卷，突顯了上皮離子通道和運輸蛋白在基本生理學和人類疾病病理生理學中的重要性。

本書的重點在於不同的離子通道和運輸蛋白家族。此外，本卷受益於藥物學貢獻者及其對近期臨床前藥物發現努力和臨床試驗結果的見解。整體而言，這些章節提供了比第一版更全面的個別上皮離子通道和運輸蛋白的覆蓋，並新增了十一個章節。因此，第三卷對生理學學生、科學家和臨床醫生來說是一個有見地的貢獻。

作者簡介

Kirk L. Hamilton was born in Baltimore, Maryland in 1953. He gained his undergraduate (biology/chemistry) and M.Sc. (ecology) degrees from the University of Texas at Arlington. He obtained his Ph.D. at Utah State University under the tutelage of Dr. James A. Gessaman, where he studied incubation physiology of Barn owls. His first post-doctoral position was at the University of Texas Medical Branch in Galveston, Texas under the mentorship of Dr. Douglas C. Eaton where he studied epithelial ion transport, specifically, the epithelial sodium channel (ENaC). He then moved to the Department of Physiology at the University of Alabama, Birmingham for additional post-doctoral training under the supervision of the late Dr. Dale J. Benos where he further studied ENaC, and non-specific cation channels. He took his first academic post in the Department of Biology at Xavier University of Louisiana in New Orleans (1990-1994). He then joined the Department of Physiology at the University of Otago in 1994, and he is currently an Associate Professor. He has focused his research on the molecular physiology and trafficking of potassium channels (specifically KCa3.1). He has published more than 60 papers and book chapters. His research work has been funded by the NIH, American Heart Association, Cystic Fibrosis Foundation, and Lottery Health Board New Zealand. Dr. Devor and he have been collaborators since 1999. When he not working, he enjoys playing guitar (blues and jazz) and volleyball. Kirk is married to Judith Rodda, a recent Ph.D. graduate in spatial ecology. They have 2 children, Nathan (b. 1995) and Emma (b. 1998).
Daniel C. Devor was born in Vandercook Lake, Michigan in 1961. His education took him through Southampton College of Long Island University, where he studied Marine Biology, before entering SUNY Buffalo for his Ph.D., under the guidance of Dr. Michael E. Duffey. During this time, he studied the role of basolateral potassium channels in regulating transepithelial ion transport. He subsequently did his post-doctoral work at the University of Alabama, Birmingham, under the mentorship of Dr. Raymond A. Frizzell, where he studied both apical CFTR and basolateral KCa3.1 in intestinal and airway epithelia. He joined the University of Pittsburgh faculty in 1995 where he is currently a Professor of Cell Biology. During this time, he has continued to study the regulation, gating and trafficking of KCa3.1 as well as the related family member, KCa2.3, publishing more than 50 papers on these topics. These studies have been funded by the NIH, Cystic Fibrosis Foundation, American Heart Association and pharmaceutical industry. When not in the lab, he enjoys photography and growing exotic plants. Dan is married to Catherine Seluga, an elementary school teacher. They have 3 children, Caitlin (b. 1990), Emily (b. 1993) and Daniel (b. 1997).

作者簡介(中文翻譯)

**Kirk L. Hamilton** 於1953年出生於馬里蘭州巴爾的摩。他在德克薩斯州阿靈頓大學獲得了生物學/化學的學士學位和生態學的碩士學位。他在猶他州立大學獲得博士學位，指導教授為James A. Gessaman博士，研究對於 Barn owls 的孵化生理學。他的第一個博士後職位是在德克薩斯州加爾維斯頓的德克薩斯大學醫學分校，指導教授為Douglas C. Eaton博士，研究上皮離子運輸，特別是上皮鈉通道（ENaC）。隨後，他轉到阿拉巴馬大學伯明翰分校的生理學系進行進一步的博士後訓練，指導教授為已故的Dale J. Benos博士，進一步研究ENaC和非特異性陽離子通道。他於1990年至1994年在路易斯安那州新奧爾良的薩維爾大學生物學系擔任第一個學術職位。1994年，他加入奧塔哥大學的生理學系，目前擔任副教授。他的研究專注於鉀通道的分子生理學和運輸（特別是KCa3.1）。他已發表超過60篇論文和書籍章節。他的研究工作得到了NIH、美國心臟協會、囊性纖維化基金會和新西蘭彩票健康委員會的資助。自1999年以來，他與Devor博士一直是合作夥伴。當他不在工作時，他喜歡彈吉他（藍調和爵士）和打排球。Kirk 與最近獲得空間生態學博士學位的Judith Rodda結婚。他們有兩個孩子，Nathan（1995年出生）和Emma（1998年出生）。

**Daniel C. Devor** 於1961年出生於密歇根州的Vandercook Lake。他的教育背景包括在長島大學的Southampton College學習海洋生物學，然後進入紐約州立大學布法羅分校攻讀博士學位，指導教授為Michael E. Duffey博士。在此期間，他研究了基底側鉀通道在調節跨上皮離子運輸中的作用。隨後，他在阿拉巴馬大學伯明翰分校進行博士後研究，指導教授為Raymond A. Frizzell博士，研究腸道和氣道上皮中的頂端CFTR和基底側KCa3.1。他於1995年加入匹茲堡大學的教職，目前擔任細胞生物學教授。在此期間，他持續研究KCa3.1的調節、開關和運輸，以及相關的家族成員KCa2.3，並在這些主題上發表了超過50篇論文。這些研究得到了NIH、囊性纖維化基金會、美國心臟協會和製藥行業的資助。當不在實驗室時，他喜歡攝影和種植異國植物。Dan 與小學教師Catherine Seluga結婚。他們有三個孩子，Caitlin（1990年出生）、Emily（1993年出生）和Daniel（1997年出生）。

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