Ferroptosis in Health and Disease
暫譯: 健康與疾病中的鐵死亡
Tang, Daolin
- 出版商: Springer
- 出版日期: 2024-10-29
- 售價: $9,690
- 貴賓價: 9.5 折 $9,206
- 語言: 英文
- 頁數: 490
- 裝訂: Quality Paper - also called trade paper
- ISBN: 303139173X
- ISBN-13: 9783031391736
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相關分類:
生物資訊 Bioinformatics
海外代購書籍(需單獨結帳)
商品描述
This updated and expanded volume gives new insights on ferroptosis - an iron-dependent form of non-apoptotic cell death. The collection of chapters discusses the two major pathways through which ferroptosis can occur: the extrinsic or transporter-dependent pathway and the intrinsic or enzyme-regulated pathway.
Readers will gain an understanding of the multiple levels, on which this special cell death is regulated. Hence, the contributions will take a closer look at epigenetic, transcriptional, posttranscriptional and posttranslational layers. Among the described regulators and transcription factors are GPX4, ACSL4 and NFE2L2.
This edited volume collects reviews related to current knowledge on the integrated molecular machinery of ferroptosis, thereby also describing how dysregulated ferroptosis is involved in human diseases.
商品描述(中文翻譯)
這本更新和擴充的卷冊提供了對鐵死亡（ferroptosis）這一依賴鐵的非凋亡細胞死亡形式的新見解。各章節討論了鐵死亡可能發生的兩個主要途徑：外源性或運輸依賴途徑，以及內源性或酶調控途徑。
讀者將能夠理解這種特殊細胞死亡的多個調控層面。因此，這些貢獻將更深入地探討表觀遺傳、轉錄、轉錄後和翻譯後的層面。在所描述的調控因子和轉錄因子中包括 GPX4、ACSL4 和 NFE2L2。
這本編輯的卷冊收集了與鐵死亡整合分子機制相關的當前知識的綜述，並描述了失調的鐵死亡如何與人類疾病相關。
作者簡介
Daolin Tang
Dr Tang's work chiefly focuses on designing and conducting molecular, cellular, and animal studies to investigate the mechanisms of damage-associated molecular pattern molecule (DAMP) release and activity in autophagy and cell death, and to evaluate novel drug candidates for the treatment of various inflammatory diseases, including cancer. His past contributions to biomedical science include the initial description of the role of high-mobility group box 1 (HMGB1), a classical DAMP, in autophagy. His recent contributions to DAMP biology include the identification of a novel function and activity of HMGB1 in infection and sterile inflammation. More recently, he has also identified a number of regulators of necroptosis, ferroptosis, pyroptosis, and alkaliptosis. In summary, Dr Tang is an outstanding investigator with a proven track record of innovation and achievement in the fields of DAMP, autophagy, and cell death.
作者簡介(中文翻譯)
唐道林博士
唐博士的研究主要集中在設計和進行分子、細胞及動物研究，以探討與損傷相關的分子模式分子（DAMP）釋放及其在自噬和細胞死亡中的作用機制，並評估新型藥物候選者以治療各種炎症性疾病，包括癌症。他在生物醫學科學方面的過去貢獻包括首次描述高流動性群體盒1（HMGB1）這一經典DAMP在自噬中的作用。他最近在DAMP生物學方面的貢獻包括識別HMGB1在感染和無菌炎症中的新功能和活性。更近期，他還識別出多種壞死性凋亡、鐵死亡、焦亡和鹼性凋亡的調節因子。總之，唐博士是一位傑出的研究者，在DAMP、自噬和細胞死亡領域擁有創新和成就的良好記錄。
