Fundamentals of Molecular Bioengineering

Di Paola, Luisa

  • 出版商: Springer
  • 出版日期: 2024-06-04
  • 售價: $4,370
  • 貴賓價: 9.5$4,152
  • 語言: 英文
  • 頁數: 271
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 3031420217
  • ISBN-13: 9783031420214
  • 海外代購書籍(需單獨結帳)

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商品描述

This textbook covers the scientific basics of molecular bioengineering, a new field where technology meets biology and chemistry, and the fundamental knowledge required for students to understand molecular mechanisms beyond biological phenomena. The textbook focuses on the role of proteins in biomolecular machinery, and it is divided into 2 parts: Part I covers the molecular thermodynamics of biological systems, and Part II discusses the computational aspects behind protein structure prediction and molecular dynamics.

In the first part of the textbook, students will find comprehensive explanations of thermodynamics and statistical mechanics, which are the basis to understand how molecular properties translate into macroscopic. Part I also offers an introduction to proteins and concepts like intermolecular forces, volumetric properties of fluids, ionization equilibria and salting-out, and protein binding and protein-protein interactions. In the second part of the textbook, students will learn about protein structure prediction and analysis, systems biology and structure-based protein networks, and computational tools and approaches for molecular dynamics simulations and protein binding and protein-protein interactions.

This textbook adds to the scholarly debate with a unique contribution, addressing important new areas of biophysical chemistry and molecular biophysics not covered in currently available textbooks. Given its breadth, the textbook is suitable for courses in molecular biophysics, biochemistry, physical chemistry and bioengineering, and will also appeal to researchers and professionals in these fields.

Part I of this book is a translation from its Italian original manuscript done with the help of artificial intelligence. A subsequent human revision of the content was done by the author. Springer Nature works continuously to further the development of tools for the production of books and on the related technologiesto support the authors.

商品描述(中文翻譯)

本教科書涵蓋了分子生物工程的科學基礎,這是一個結合技術、生物學和化學的新領域,並提供學生理解生物現象背後分子機制所需的基礎知識。教科書專注於蛋白質在生物分子機器中的作用,分為兩個部分:第一部分介紹生物系統的分子熱力學,第二部分討論蛋白質結構預測和分子動力學的計算方面。

在教科書的第一部分,學生將找到對熱力學和統計力學的全面解釋,這是理解分子性質如何轉化為宏觀性質的基礎。第一部分還介紹了蛋白質和相關概念,如分子間力、流體的體積性質、離子平衡和鹽析,以及蛋白質結合和蛋白質間相互作用。在教科書的第二部分,學生將學習蛋白質結構預測和分析、系統生物學和基於結構的蛋白質網絡,以及分子動力學模擬和蛋白質結合和蛋白質間相互作用的計算工具和方法。

本教科書在學術辯論中提供了獨特的貢獻,涵蓋了目前可用教科書中未涉及的重要生物物理化學和分子生物物理領域。由於其廣度,本教科書適用於分子生物物理學、生物化學、物理化學和生物工程等課程,同時也適合這些領域的研究人員和專業人士。

本書的第一部分是從原始意大利手稿經由人工智能的幫助進行翻譯。作者隨後對內容進行了人工修訂。Springer Nature不斷努力發展用於圖書製作和相關技術的工具,以支持作者的工作。

作者簡介

​Luisa Di Paola is an Assistant Professor at the Campus Bio-Medico University of Rome (Italy), where she lectures graduate and undergraduate courses like Chemical Engineering of Artificial Organs, Molecular Thermodynamics of Biological Systems, and Environment and Chemical Engineering Fundamentals. She holds a PhD in Industrial Chemical Processing from the University of Rome La Sapienza, and from March 2021 to July 2022 she received a Fullbright Scholar award for advanced research and university lecturing in the United States, with the project "Unravelling Allostery Dynamics Combining Perturbation Methods and Protein Contact Networks Approach" at the University of Nevada, Rena, USA. With 100+ articles published in international journals, Di Paola has been focusing her attention on molecular thermodynamics of complex systems, including phase equilibria and physicochemical properties of protein solutions, purification of protein compounds and polymeric systems rheology. She has also been interested on artificial organs, complex systems analysis with emphasis on biomedical and biological systems, protein systems biology, and compartmental models for the dynamic analysis of biomedical images.

作者簡介(中文翻譯)

Luisa Di Paola是羅馬Campus Bio-Medico大學的助理教授,她在該校教授研究生和本科課程,如人工器官化學工程、生物系統的分子熱力學以及環境和化學工程基礎等。她擁有羅馬拉斯佩齊亞大學的工業化學加工博士學位,並於2021年3月至2022年7月獲得富布萊特學者獎,進行在美國的高級研究和大學講學,項目名為“結合干擾方法和蛋白質接觸網絡方法解析變態動力學”,地點為美國內華達大學雷諾分校。Di Paola在國際期刊上發表了100多篇文章,專注於複雜系統的分子熱力學,包括相平衡和蛋白質溶液的物理化學性質,蛋白質化合物和聚合物系統的純化以及流變學。她還對人工器官、生物醫學和生物系統的複雜系統分析、蛋白質系統生物學以及用於動態分析生物醫學影像的區域模型感興趣。