Rodent Quality Control: Genes and Bugs: Monitoring Health and Genetics of Laboratory Animals
暫譯: 實驗動物的基因與健康監控：鼠類品質控制與病原體分析
Benavides, Fernando J., Hansen, Axel Kornerup
相關主題
商品描述
This book shows how and why quality assurance programmes should be implemented in laboratory rodent facilities to monitor animal health and genetic status. It covers common practice to assure the desired level of microbiological and genetic surveillance of both genetically standardized and genetically altered laboratory mice and rats. In particular, the book introduces readers to the standardized genetic nomenclature and provides step-by-step protocols for genetic monitoring of the animals. International standards of health monitoring programs are discussed and statistical aspects thereof are explored. Furthermore, the book reviews common infectious diseases in laboratory rodents and guides the reader in monitoring the animals' health status through application of current diagnostic methods.
This book adresses researchers, technicians and zookeepers working in laboratory rodent facilities.
商品描述(中文翻譯)
本書展示了為什麼以及如何在實驗室鼠類設施中實施品質保證計劃，以監測動物的健康和遺傳狀態。內容涵蓋了確保對基因標準化和基因改造的實驗室小鼠及大鼠進行微生物和遺傳監測所需的常見做法。特別地，本書向讀者介紹了標準化的遺傳命名法，並提供了動物遺傳監測的逐步操作流程。書中討論了健康監測計劃的國際標準，並探討了相關的統計方面。此外，本書回顧了實驗室鼠類中常見的傳染病，並指導讀者通過應用當前的診斷方法來監測動物的健康狀態。
本書針對在實驗室鼠類設施工作的研究人員、技術人員和動物園飼養員。
作者簡介
Dr. Fernando Benavides is Professor and Director of the Laboratory Animal Genetic Services at MD Anderson Cancer Center, Houston, Texas. Dr. Benavides received a DVM and a PhD in Genetics from the University of Buenos Aires, Argentina. His PhD training on Mouse Genetics was done at Institut Pasteur, Paris, France. Dr. Benavides is a diplomate of the American College of Laboratory Animal Medicine (ACLAM) since 2003 and he serves as IACUC veterinarian for the MD Anderson Cancer Center since 2006. Dr. Benavides has a strong background in positional cloning of spontaneous mutations and has described several new mouse models. He has published 70 peer-reviewed papers in scientific journals, several books, chapters and reviews on Mouse Genetics and Genetic Quality Controls in mice and rats.
Dr. Axel Kornerup Hansen graduated in 1985 as DVM from the Royal Veterinary and Agricultural University in Copenhagen, Denmark. After two years in a small animal hospital, he became head of laboratories at Møllegaard Breeding Center, today part of Taconic Ltd. In 1993 he became associate director at the Department of Experimental Medicine at the Faculty of Health & Medical Sciences at the University of Copenhagen. In 1996 he was awarded the degree of Dr. Vet. Sci. based upon his thesis on the impact of bacteria in laboratory rats. From 1997 he has been professor in laboratory animal science and welfare at the Royal Veterinary and Agricultural University, which in 2007 became a part of University of Copenhagen. In 2000 Dr. Hansen was made charter diplomat and was together with six others founding the European College of Laboratory Animal Medicine. His research area has primarily been on how infections and the microbiota have an impact on laboratory animal models for human diseases and how this works in conjunction with the diet, but he has also published work on laboratory animal welfare. Dr. Hansen has published 223 peer-reviewed papers in scientific journals, 20 proceedings papers, 17 papers in non-peer journals, and two full textbooks, i.e. 'The Laboratory Swine' and 'Handbook of Laboratory Animal Bacteriology' from CRC Press. He is chairing the board of the Danish National Centre for the 3Rs.
作者簡介(中文翻譯)
費爾南多·貝納維德斯博士是德克薩斯州休士頓MD安德森癌症中心實驗動物遺傳服務的教授及主任。貝納維德斯博士於阿根廷布宜諾斯艾利斯大學獲得獸醫學博士（DVM）及遺傳學博士（PhD）。他的博士研究專注於小鼠遺傳學，於法國巴黎的巴斯德研究所完成。自2003年以來，貝納維德斯博士是美國實驗動物醫學學會（ACLAM）的認證專家，自2006年以來擔任MD安德森癌症中心的IACUC獸醫。貝納維德斯博士在自發性突變的定位克隆方面具有深厚的背景，並描述了幾個新的小鼠模型。他在科學期刊上發表了70篇經過同行評審的論文，以及幾本書籍、章節和有關小鼠遺傳學及小鼠和大鼠的遺傳質量控制的評論。
阿克塞爾·科爾內魯普·漢森博士於1985年畢業於丹麥哥本哈根的皇家獸醫與農業大學，獲得獸醫學博士（DVM）。在一家小動物醫院工作兩年後，他成為Møllegaard繁殖中心的實驗室負責人，該中心如今是Taconic Ltd.的一部分。1993年，他成為哥本哈根大學健康與醫學科學學院實驗醫學系的副主任。1996年，他基於對實驗室大鼠中細菌影響的論文獲得獸醫科學博士（Dr. Vet. Sci.）學位。自1997年以來，他一直擔任皇家獸醫與農業大學的實驗動物科學與福利教授，該大學於2007年成為哥本哈根大學的一部分。2000年，漢森博士成為特許外交官，並與其他六人共同創立了歐洲實驗動物醫學學院。他的研究領域主要集中在感染和微生物群如何影響人類疾病的實驗動物模型，以及這如何與飲食相互作用，但他也發表了有關實驗動物福利的研究。漢森博士在科學期刊上發表了223篇經過同行評審的論文、20篇會議論文、17篇非同行評審期刊的論文，以及兩本完整的教科書，即CRC Press出版的《實驗室豬》和《實驗室動物細菌學手冊》。他擔任丹麥國家3Rs中心的董事會主席。
