The Skeletal Muscle: Plasticity, Degeneration and Epigenetics
暫譯: 骨骼肌：可塑性、退化與表觀遺傳學
Ji, Li Li
- 出版商: Springer
- 出版日期: 2026-08-30
- 售價: $11,180
- 貴賓價: 9.5 折 $10,621
- 語言: 英文
- 頁數: 659
- 裝訂: Quality Paper - also called trade paper
- ISBN: 3031883632
- ISBN-13: 9783031883637
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相關主題
商品描述
Skeletal muscle is not an organ merely for locomotion with simple anatomical and metabolic features as has been viewed for a long time. The understanding that physical activity plays a vital role in health promotion and disease prevention under the slogan of "exercise is medicine" has dramatically increased the enthusiasm and demand for knowledge about the skeletal muscle. This book, "The Skeletal Muscle: Plasticity, Degeneration and Epigenetics", is a follow up of another book authored by the Editor, which provides the morphological, physiological, biochemical and molecular biological foundations for organ's response and adaptation to functional demand, and for the mechanisms and prevention for the organ's pathogenesis and degeneration. Research in the past several decades has demonstrated that skeletal muscle has a tremendous ability to undergo internal changes in response to functional, environmental, nutritional and genetic challenges, through various neural, endocrine and autocrine pathways for signal transduction. Although the contractile proteins show a relatively slow turnover, many organelles and constituents in the myocyte exhibit considerable remodeling throughout the muscle's life cycle. In this regard, mitochondrion plays a central role in the crosstalk of signaling not only in its own turnover and quality control, but also in exerting important influences on other vital cellular functions. On the opposite side, skeletal muscle is highly vulnerable to disuse and misuse that can cause injury, inflammation, degeneration and atrophy. The various chapters in this book, contributed by the experts in the field, will introduce and review the most concurrent knowledge to address important issues related to muscle plasticity, pathogenesis, disease and aging. Potential strategies to prevent and ameliorate the above problems in a whole-body perspective will be highlighted to provide the readers with the inspiration to learn and work with this important and intriguing organ.
商品描述(中文翻譯)
長久以來，骨骼肌一直被視為僅供人體移動、具有簡單解剖與代謝特徵的器官。然而，隨著「運動就是良藥」（exercise is medicine）這項理念逐漸受到重視，人們日益了解身體活動在促進健康與預防疾病方面所扮演的重要角色，也因此大幅提升了對骨骼肌相關知識的興趣與需求。
本書《骨骼肌：可塑性、退化與表觀遺傳學》（The Skeletal Muscle: Plasticity, Degeneration and Epigenetics）是本書編者另一部著作的延伸，前作為理解器官如何回應功能需求並產生適應，以及器官發病與退化的機制和預防方法，提供了形態學、生理學、生物化學與分子生物學方面的基礎。
過去數十年的研究顯示，骨骼肌具有極為驚人的能力，能透過多種神經、內分泌與自分泌訊息傳導途徑，因應功能、環境、營養與遺傳方面的挑戰而產生內部變化。儘管收縮蛋白的更新速度相對緩慢，肌細胞中的許多細胞器與組成成分，仍會在肌肉的整個生命週期中持續進行顯著的重塑。
在這方面，粒線體不僅在自身的更新與品質控制中扮演訊息交互作用的核心角色，也會對其他重要的細胞功能產生重大影響。另一方面，骨骼肌也極易受到缺乏使用與錯誤使用的影響，進而造成損傷、發炎、退化與萎縮。
本書各章由該領域的專家撰寫，將介紹並回顧與肌肉可塑性、發病機制、疾病及老化相關的重要最新知識。同時，本書也將從全身性的觀點，著重探討預防與改善上述問題的潛在策略，期望啟發讀者進一步了解並投入這個重要且引人入勝的器官之研究與實務工作。
作者簡介
Li Li Ji has been Professor and Director of the Laboratory of Physiological Hygiene and Exercise at the University of Minnesota Twin Cities since 2011. He served as the Director of School of Kinesiology during 2011-2017. Li Li Ji received his PhD (1985) and postdoctoral training (1985-87) at the Institute for Enzyme Research at University of Wisconsin-Madison and served as assistant and associate professor at University of Illinois at Urbana-Champaign (1987-1993) and associate (1994-1997) and full professor at University of Wisconsin-Madison (1997-2011), including 10 years as Chair of Kinesiology Department. Professor Ji's research expertise is cellular and molecular exercise physiology, especially the roles of free radicals and antioxidants in muscle function, adaptation to exercise, pathogenic mechanism, cell signaling and aging. He has published 200 peer-reviewed articles and book chapters and given over 180 invited international and domestic lectures. His recent research focus has been on mitochondrial quality control and redox signaling in skeletal muscle. Professor Ji has served on many editorial boards and currently is the deputy editor-in-chief for the journal Sport Medicine and Health Science. He has been a member of the National Academy of Kinesiology (NAK) since 2006, a Fellow of the American College of Sports Medicine (ACSM) since 1990, and Fellow of the Society for Redox Biology and Medicine (SfRBM) since 2022. His scholarly work has received 25,000 citations and earned a Google Scholar h-index of 80. Professor Ji received the prestigious Citation Award from ACSM in 2023 and was granted an Honorary Doctorate Degree (Doctor Honoris Causa) from Hungarian National University of Sport Science in 2020. He has established broad collaborations with universities and research institutions over the world. In 2023 Professor Ji received a Special Contribution Award from the Chinese Physiological Society for his decades-long collaboration with China in Exercise Physiology.
作者簡介(中文翻譯)
Li Li Ji 自 2011 年起擔任 University of Minnesota Twin Cities 生理衛生與運動實驗室教授兼主任，並於 2011 至 2017 年期間擔任運動機能學院院長。
Li Li Ji 於 1985 年取得博士學位，並於 1985 至 1987 年在 University of Wisconsin-Madison 的酵素研究所接受博士後訓練。1987 至 1993 年間，他於 University of Illinois at Urbana-Champaign 擔任助理教授及副教授；1994 至 1997 年於 University of Wisconsin-Madison 擔任副教授，並自 1997 至 2011 年擔任教授，其中有 10 年兼任運動機能學系系主任。
Ji 教授的研究專長為細胞與分子運動生理學，尤其聚焦於自由基與抗氧化劑在肌肉功能、運動適應、致病機制、細胞訊號傳遞及老化等方面所扮演的角色。他已發表 200 篇經同儕審查的學術論文與書籍章節，並受邀在國際及國內發表超過 180 場演講。
近年來，他的研究重點為骨骼肌中的粒線體品質控制與氧化還原訊號傳遞。Ji 教授曾擔任多本期刊的編輯委員，目前是期刊 Sport Medicine and Health Science 的副總編輯。
自 2006 年起，他一直是 National Academy of Kinesiology（NAK）會員；自 1990 年起為 American College of Sports Medicine（ACSM）會士；自 2022 年起為 Society for Redox Biology and Medicine（SfRBM）會士。他的學術研究已獲得 25,000 次引用，Google Scholar h-index 達 80。
Ji 教授於 2023 年獲 ACSM 頒發享有盛譽的 Citation Award，並於 2020 年獲 Hungarian National University of Sport Science 授予名譽博士學位（Doctor Honoris Causa）。他已與世界各地的大學及研究機構建立廣泛的合作關係。
2023 年，Ji 教授因數十年來與中國在運動生理學領域的合作，獲 Chinese Physiological Society 頒發特別貢獻獎。
