Omics Approaches in Biofilm Research: Perspectives and Applications
暫譯: 生物膜研究中的組學方法：觀點與應用
Busi, Siddhardha, Pattnaik, Subhaswaraj, Prasad, Ram
- 出版商: Springer
- 出版日期: 2025-07-08
- 售價: $8,730
- 貴賓價: 9.5 折 $8,294
- 語言: 英文
- 頁數: 455
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 3031918622
- ISBN-13: 9783031918629
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相關分類:
生物資訊 Bioinformatics
海外代購書籍(需單獨結帳)
相關主題
商品描述
The increased incidence of microorganisms' selective pressure to traditional antibiotics has led to the emergence of multi-drug resistance (MDR) phenomena and has become a global health issue with a catastrophic influence on millions of lives, as well as the global economy. The inherent tendency of pathogenic microorganisms to infer MDR could be attributed to their ability to form recalcitrant biofilm matrices. The biofilm matrix not only advocates chronic nosocomial infections, but also critically provides protection against environmental stress including antibiotic therapies. Biofilm-mediated MDR has posed a serious challenge to human well-being. Henceforth, it is important to understand the pathophysiology of biofilms and the concomitant development of diagnostic & therapeutic modalities to counteract biofilm-mediated chronic infections.The lack of understanding on biofilm biology has a critical negative influence on diagnostic and therapeutic efforts. Therefore, it is imperative to discover the right course of action to understand biofilm mechanics. The advent of Omics-based approaches has provided a holistic realization to understand biofilm ecology with special reference to the pathophysiological interactions of antibiotic-resistant genes, protein-protein interactions, and response-based interactions with therapeutic agents upon infection. The inherent ability of several Omics-based approaches has provided a comprehensive understanding of biofilm dynamics at various levels of organization such as genes, mRNA, proteins, and their regulation. Omics-based tools such as metagenomics, transcriptomics, proteomics, metabolomics, etc. have provided a new horizon to understand and tackle the biofilm-mediated antibiotic resistance. The integrated approach to consider multi-Omics tools (e.g. genomics, transcriptomics, proteomics, lipidomics, metabolomics, etc.) has further improved our understanding of the mechanisms associated with biofilm resistome profile. The applications of transcriptomics, proteomics, and metabolomics profiles of biofilm matrices could provide new dimensions in relation to the characteristic properties of different ARGs, their relative expression profiles, and their metabolic intervention in biofilm mechanics. Also, advanced integrated Phenomics, Lipidomics, and Culturomics approaches could provide novel avenues to understand the diverse range of biofilm phenotypes, their macromolecular reorganization profiles, and molecular tools for identification of microbial species in the complex biofilm microenvironment.
Based on the advancement in omics-based tools, "Omics Approaches in Biofilm Research: Perspectives and Applications" integrates the current knowledge of biofilm microenvironment and innovative strategies to address biofilm mediated drug resistance. This work provides a comprehensive platform to enhance our knowledge, diagnosis and strategies to mitigate biofilms and associated diseases.
商品描述(中文翻譯)
微生物對傳統抗生素的選擇性壓力增加，導致多重藥物抗性（MDR）現象的出現，並已成為全球健康問題，對數百萬人的生命以及全球經濟產生了災難性的影響。病原微生物固有的傾向於產生MDR可歸因於其形成頑固生物膜基質的能力。生物膜基質不僅促進慢性醫院感染，還對抗生素治療等環境壓力提供了重要的保護。生物膜介導的MDR對人類健康構成了嚴重挑戰。因此，了解生物膜的病理生理學以及隨之發展的診斷和治療方法以對抗生物膜介導的慢性感染是非常重要的。對生物膜生物學的缺乏理解對診斷和治療工作產生了重大負面影響。因此，發現正確的行動方案以理解生物膜的機制是迫在眉睫的。基於Omics的方法的出現，提供了全面的認識，以理解生物膜生態，特別是抗生素抗性基因的病理生理相互作用、蛋白質-蛋白質相互作用以及在感染時與治療劑的反應性相互作用。幾種基於Omics的方法的固有能力，提供了對生物膜動力學在基因、mRNA、蛋白質及其調控等各個組織層次的全面理解。基於Omics的工具，如宏基因組學、轉錄組學、蛋白質組學、代謝組學等，為理解和應對生物膜介導的抗生素抗性提供了新的視野。考慮多種Omics工具（例如基因組學、轉錄組學、蛋白質組學、脂質組學、代謝組學等）的綜合方法，進一步改善了我們對生物膜抗性組合特徵相關機制的理解。生物膜基質的轉錄組學、蛋白質組學和代謝組學特徵的應用，可能為不同抗藥基因（ARGs）的特徵性質、相對表達特徵及其在生物膜機制中的代謝干預提供新的維度。此外，先進的綜合表型學、脂質組學和培養組學方法可能為理解多樣的生物膜表型、其大分子重組特徵以及在複雜生物膜微環境中識別微生物物種的分子工具提供新途徑。
基於Omics工具的進步，《生物膜研究中的Omics方法：觀點與應用》整合了生物膜微環境的當前知識和創新策略，以應對生物膜介導的藥物抗性。本書提供了一個全面的平台，以增強我們的知識、診斷和減輕生物膜及相關疾病的策略。
作者簡介
Dr. Siddhardha Busi, Ph.D. is an Associate Professor in the Department of Microbiology, Pondicherry University, India. He obtained his PhD from the Biology Division at CSIR-IICT in Hyderabad, India. Dr. Siddhardha has nearly 13 years of research experience in the fields of Microbiology, Microbial Pathogenesis, Antimicrobial drug discovery, and Nanobiotechnology. He has dedicated the past 13 years to the research and development of antimicrobial compounds and the discovery of antimicrobial drugs.
Dr. Subhaswaraj Pattnaik, Ph.D. is an Assistant Professor in the Department of Zoology, Govt. Women's College, Sambalpur University, Sambalpur, Odisha, India. He obtained his Ph.D. from the Department of Microbiology, School of Life Sciences, Pondicherry University, Puducherry, India. He completed his Post-Doctoral Research (National-Post-doctoral Fellowship program from DST-SERB, Govt. of India) in the Department of Biotechnology and Bioinformatics, Sambalpur University, Sambalpur, Odisha, India.
the mitigation of bacterial quorum sensing regulatory network and biofilm-associated infections, particularly in ESKAPE pathogens. He is extensively working in the field of identifying bioactive compounds from natural resources in the therapeutic management of biofilm-associated chronic infections in ESKAPE pathogens by targeting species-specific quorum sensing communication by exploring the analytical techniques and bioinformatics-based molecular tools. He is also working on the development of therapeutic moieties against UTIs using plant-derived compounds and sustainable nano-based drug formulation for the efficient management of antibiotic resistance by regulation of bacterial biofilm mechanics. Dr. Pattnaik has more than fifty publications to his credit, including several research and review papers in peer-reviewed international journals, and several book chapters in the edited books of reputed publishing groups. He is also a member of many national and international scientific societies.
Ram Prasad, Ph.D. is Associate Professor, Department of Botany, Mahatma Gandhi Central University, Motihari, Bihar, India. His research interests include applied & environmental microbiology, plant-microbe interactions, sustainable agriculture, chemistry of biology, and nanobiotechnology. Dr. Prasad has more than 250 publications to his credit including research papers, review articles & book chapters, seven patents issued or pending, and several edited or authored books. Dr. Prasad has 12 years of teaching experience and has been awarded the Young Scientist Award & Prof. J.S. Datta Munshi Gold Medal by the International Society for Ecological Communications; Fellow of Biotechnology Research Society of India; Fellow of the Society for Applied Biotechnology; the American Cancer Society UICC International Fellowship for Beginning Investigators, USA; Outstanding Scientist Award in the field of Microbiology by Venus International Foundation; BRICPL Science Investigator Award and Research Excellence Award etc. He has been serving as an editorial board member: Nanotechnology Reviews; Green Processing and Synthesis; BMC Microbiology; BMC Biotechnology; Current Microbiology; Archives of Microbiology; Annals of Microbiology; BioMed Research International,
作者簡介(中文翻譯)
Dr. Siddhardha Busi, Ph.D. 是印度龐迪榭里大學微生物學系的副教授。他在印度海得拉巴的 CSIR-IICT 生物學部獲得博士學位。Dr. Siddhardha 在微生物學、微生物致病學、抗微生物藥物發現和奈米生物技術等領域擁有近 13 年的研究經驗。他在過去的 13 年中專注於抗微生物化合物的研究與開發以及抗微生物藥物的發現。
Dr. Subhaswaraj Pattnaik, Ph.D. 是印度奧里薩邦桑巴爾普爾大學政府女子學院的助理教授。他在印度龐迪榭里大學生命科學學院的微生物學系獲得博士學位。他在印度奧里薩邦桑巴爾普爾大學的生物技術與生物信息學系完成了博士後研究（來自印度政府 DST-SERB 的國家博士後獎學金計劃）。
他專注於減緩細菌群體感應調控網絡和生物膜相關感染，特別是在 ESKAPE 病原體中。他在從自然資源中識別生物活性化合物的領域進行廣泛研究，旨在通過探索分析技術和基於生物信息學的分子工具，針對特定物種的群體感應通信來治療與生物膜相關的慢性感染。他還致力於利用植物衍生化合物開發針對尿路感染（UTIs）的治療分子，以及可持續的奈米藥物配方，以有效管理抗生素抗性，通過調節細菌生物膜的機械特性。Dr. Pattnaik 擁有超過五十篇的出版物，包括多篇在同行評審的國際期刊上發表的研究和綜述文章，以及多本知名出版集團編輯的書籍章節。他還是許多國內外科學學會的成員。
Ram Prasad, Ph.D. 是印度比哈爾邦摩提哈里甘地中央大學植物學系的副教授。他的研究興趣包括應用與環境微生物學、植物-微生物相互作用、可持續農業、生物化學和奈米生物技術。Dr. Prasad 擁有超過 250 篇的出版物，包括研究論文、綜述文章和書籍章節，擁有七項已發或待發的專利，以及多本編輯或撰寫的書籍。Dr. Prasad 擁有 12 年的教學經驗，並獲得國際生態傳播學會的青年科學家獎和 J.S. Datta Munshi 金獎；印度生物技術研究學會的研究員；應用生物技術學會的研究員；美國癌症協會 UICC 初始研究者國際獎學金；由 Venus International Foundation 頒發的微生物學領域傑出科學家獎；BRICPL 科學研究者獎和研究卓越獎等。他還擔任多本期刊的編輯委員會成員，包括奈米技術評論、綠色加工與合成、BMC 微生物學、BMC 生物技術、當前微生物學、微生物學檔案、微生物學年鑑和 BioMed Research International。
