Biomaterial-Based Additive Manufacturing in Tissue Engineering and Regeneration
暫譯: 生物材料基礎的增材製造在組織工程與再生中的應用

生物材料是經過工程設計以與生物系統互動，用於醫療和治療目的的物質。基於生物材料的增材製造在組織工程中是一個快速發展的領域，持續進行研究和開發。隨著技術的進步，它可能在再生醫學和個性化醫療的發展中扮演關鍵角色。基於生物材料的增材製造，也稱為利用可生物降解或生物可用聚合物材料的3D生物列印，是一項具有巨大潛力和前景的尖端技術，適用於組織工程和再生。這種創新方法將生物材料或工程生物材料與精確或定制的列印相結合，以開發出模擬天然組織結構和功能的複雜三維結構。在為組織工程或再生開發3D列印產品時，一個重要的方面是生物材料的選擇、使用這些生物材料開發生物墨水、細胞整合、定制、血管化以及產品的生物降解性。儘管3D生物列印在各種應用中顯示出潛力，有可能徹底改變器官移植和組織工程，但仍面臨幾個挑戰，例如確保適當的血管化、改善列印產品的機械性能，以及處理具有倫理考量的法規方面。因此，本書將強調組織工程和再生，這是一個旨在恢復、修復或替代受損或失去的生物組織的跨學科領域。此外，各章節將介紹研究的最新變化，顯示出可生物降解產品的定制製造，以及組織工程和再生的未來。

Dr. Sudarshan Singh, a Ph.D. in pharmaceutical sciences and presently working as a Frontier Proactive Researcher at the Faculty of Pharmacy, Chiang Mai University, Thailand. His current research is focused on utilization of bioinspired polymeric materisl via additive manufacturing in fabrication of composite fortified to counteract the effect of dermal inflammation followed cellular bioassay, intracellular uptake, and the development of engineered multifunctional nature originated biomaterials for incorporating them in various drug delivery. Whereas previous research investigation was emphasized on the fabrication of lipid vesicular entrapped bioactive compounds as biodegradable two dimensional scaffolds using biomaterial for enhancement of intracellular uptake in immortal keratinocyte cell and its anti-inflammatory responses on lipopolysaccharides-stimulated macrophage cells. Dr. Singh has authored several technical books and book chapters and 200 plus research/review papers in reputed peer-reviewed journals. He has registered 6 patents on his credit. He is working as reviewer of various international journals. He has eleven years of teaching experience in undergraduate and postgraduate courses of pharmacy with more than six years of postdoctoral research experience. He has guided several undergraduate and postgraduate students in their project work. He is a life member of professional bodies such as the Society of Pharmacovigilance India and a registered pharmacist at the State Pharmacy Council of Chhattisgarh, India.

Dr. Popat Mohite is a distinguished academician and researcher in the field of pharmaceutical sciences. He currently serves as the Associate Professor and Head of the Department at St. John Institute of Pharmacy and Research, Palghar, Maharashtra, India. With an impressive teaching career spanning over 18 years, he has made significant contributions to both academia and research. Throughout his career, he has demonstrated a strong commitment to scientific advancement and innovation. He has authored and co-authored over 150 plus research and review articles in prestigious national and international journals, and 30 plus book chapters reflecting his expertise and active engagement in cutting-edge pharmaceutical research. In addition to his prolific publication record, Dr. Mohite has secured research grants from the University of Pune, showcasing his ability to lead and manage funded research projects. He has mentored several postgraduate students, guiding them in their academic and research endeavours. His dedication to nurturing young minds and fostering research culture among students has been one of the cornerstones of his academic career. Dr. Mohite is also an inventor, with 2 plus patents, underscoring his innovative contributions to pharmaceutical formulation and drug development. In recognition of his outstanding work, Dr. Mohite has been honoured with several prestigious awards, including the Young Researcher Award, Young Scientist Award, and Young Faculty Award.

Dr. Deepanjan Datta is currently working as an Assistant Professor at Manipal College of Pharmaceutical Sciences, Department of Pharmaceutics, Manipal Academy of Higher Education. In the year 2022, he pursued his Ph.D. in Pharmaceutics at Birla Institute of Technology and Sciences, India. During this period, he has worked extensively in the drug delivery field, including topical or transdermal and ocular drug delivery. He has also developed microneedle, contact lenses containing a peptide for the first time. Also, he has fabricated biomedical adhesive devices for enhanced transdermal drug delivery using ionic liquids. He has also developed peptide gel formulations for the Defense Research and Development Organization (DRDO). He has also received a seed grant from the Incubation Centre of Bio-Nest NIPER Guwahati and Manipal College of Pharmaceutical Sciences for the acceptance of his research proposal. Taken together, he has published a decent number of articles and has filed 10 plus patents based on research ideation. In the year 2019, he was awarded the Young Scientist award by the Controlled Release Society in recognition of his excellent contributions to the field of controlled release. His experience includes working at Dr. Reddy's Laboratories, Hyderabad, as a formulation and research scientist in the topical and transdermal division. He is also a peer-reviewer of various SCI journals.

Dr. Sudarshan Singh 擁有藥學博士學位，目前在泰國清邁大學藥學院擔任前沿主動研究員。他目前的研究專注於利用生物啟發的聚合物材料，通過增材製造技術製作複合材料，以對抗皮膚炎症的影響，並進行細胞生物測定、細胞內攝取以及開發工程化的多功能天然來源生物材料，以便將其應用於各種藥物傳遞系統。之前的研究則強調製作脂質囊泡包裹的生物活性化合物，作為可生物降解的二維支架，使用生物材料來增強不朽角質細胞的細胞內攝取及其對脂多醣刺激的巨噬細胞的抗炎反應。Dr. Singh 已出版多本技術書籍和書章，並在知名的同行評審期刊上發表了超過200篇研究/綜述論文。他擁有6項專利，並擔任多個國際期刊的審稿人。他在藥學本科及研究生課程中擁有11年的教學經驗，並有超過6年的博士後研究經驗。他指導過多位本科及研究生學生的專案工作。他是印度藥物監測學會的終身會員，並在印度恰蒂斯加爾邦藥學委員會註冊為藥師。

Dr. Popat Mohite 是藥學領域的傑出學者和研究者。目前擔任印度馬哈拉施特拉邦帕爾加爾聖約翰藥學與研究學院的副教授及系主任。他擁有超過18年的教學經歷，對學術界和研究做出了重要貢獻。在他的職業生涯中，他展現了對科學進步和創新的強烈承諾。他在國內外知名期刊上發表了超過150篇研究和綜述文章，以及30篇書章，反映了他的專業知識和在前沿藥學研究中的積極參與。除了豐富的出版紀錄外，Dr. Mohite 還獲得了普納大學的研究資助，顯示了他領導和管理資助研究項目的能力。他指導過多位研究生，幫助他們在學術和研究方面的努力。他對培養年輕人才和促進學生研究文化的奉獻精神是他學術生涯的基石之一。Dr. Mohite 也是一位發明家，擁有2項以上的專利，突顯了他在藥物配方和藥物開發方面的創新貢獻。因其卓越的工作，Dr. Mohite 獲得了多項著名獎項，包括青年研究者獎、青年科學家獎和青年教職員獎。

Dr. Deepanjan Datta 目前在馬尼帕爾高等教育學院的馬尼帕爾藥學院擔任助理教授。2022年，他在印度比爾拉科技與科學學院獲得藥學博士學位。在此期間，他在藥物傳遞領域進行了廣泛的研究，包括局部或透皮及眼用藥物傳遞。他還首次開發了含有肽的微針和隱形眼鏡。此外，他還製作了生物醫學粘合裝置，以增強透皮藥物傳遞，使用了離子液體。他還為國防研究與發展組織（DRDO）開發了肽凝膠配方。他還獲得了來自Bio-Nest NIPER Guwahati和馬尼帕爾藥學院的孵化中心的種子資助，以支持他的研究提案。總的來說，他發表了相當數量的文章，並基於研究構思申請了10項以上的專利。在2019年，他因在控制釋放領域的卓越貢獻而獲得了控制釋放學會的青年科學家獎。他的經歷包括在海得拉巴的Dr. Reddy's Laboratories擔任局部和透皮部門的配方及研究科學家。他也是多個SCI期刊的同行評審人。