商品描述
This book discusses the bidirectional relationship between vitamin D and mineral ions, detailing how these interactions form a physiological feed-forward loop essential for maintaining health, which becomes dysregulated in various disease states. This book compiles the roles and regulatory mechanisms of vitamin D and mineral ions in human health and disease. The chapters focus on the diverse physiological functions of vitamin D and the critical role of magnesium in maternal-fetal development and the importance of calcium in the gut-glucose axis. The overall content of the book reemphasizes the essential roles of vitamin D and mineral ions in maintaining normal physiological functions across multiple organ systems. Vitamin D is requisite for physiological functions of cells and organs. Vitamin D facilitates the absorption of essential minerals, including calcium, phosphorus, magnesium, copper, zinc, iron, and selenium. While certain minerals, including magnesium and zinc act as cofactors to activate vitamin D. Similarly, calcium and phosphorus are involved in vitamin D-mediated signaling events. Vitamin D also enables the uptake of toxic elements, including lead, arsenic, aluminum, cobalt, and strontium. Although, vitamin D and calcium interactions are well described in the literature, more generalized roles, and regulation of vitamin D on mineral ion metabolism is not well-defined. This book will serve as a concise reference on vitamin D regulation and its diverse biological functions, including roles in mineral ion homeostasis, antimicrobial activity, immune modulation, and sleep regulation. It also addresses the clinical implications of vitamin D in brain health, fracture healing, and tumorigenesis. The content is accessible to readers with minimal prior knowledge of the field.
商品描述(中文翻譯)
本書探討維他命D與礦物離子之間的雙向關係，詳細說明這些相互作用如何形成一個對維持健康至關重要的生理前饋迴路，而在各種疾病狀態下會失調。本書彙編了維他命D和礦物離子在人類健康與疾病中的角色及調控機制。各章節專注於維他命D的多樣生理功能，以及鎂在母胎發展中的關鍵角色和鈣在腸道-葡萄糖軸中的重要性。本書的整體內容重新強調維他命D和礦物離子在維持多個器官系統正常生理功能中的基本角色。維他命D對細胞和器官的生理功能是必需的。維他命D促進必需礦物質的吸收，包括鈣、磷、鎂、銅、鋅、鐵和硒。某些礦物質，包括鎂和鋅，則作為輔因子來激活維他命D。同樣，鈣和磷也參與維他命D介導的信號事件。維他命D還能促進有毒元素的攝取，包括鉛、砷、鋁、鈷和鍶。儘管文獻中對維他命D與鈣的相互作用有詳細描述，但維他命D對礦物離子代謝的更廣泛角色和調控尚未明確界定。
本書將作為維他命D調控及其多樣生物功能的簡明參考，包括在礦物離子穩態、抗微生物活性、免疫調節和睡眠調控中的角色。它還探討了維他命D在大腦健康、骨折癒合和腫瘤生成中的臨床意涵。內容對於對該領域知識較少的讀者也易於理解。
作者簡介
Dr. Mohammed S. Razzaque is currently a Professor of Pathology at the University of Texas Rio Grande Valley (UTRGV) at Edinburg, Texas (U.S.A.). He obtained a Doctorate (Ph.D.) in pathology from Nagasaki University (Japan) and holds a degree in medicine (M.B.B.S.) from Chittagong University (Bangladesh). Dr. Razzaque is a Visiting Professor of Department of Oral Health Policy & Epidemiology at the Harvard School of Dental Medicine, Boston (U.S.A.), International Kazakh-Turkish University, Turkistan (Kazakhstan), University of Antwerp, Antwerp (Belgium), Al-Farabi Kazakh National University, Almaty (Kazakhstan), University Kuala Lumpur Royal College of Medicine Perak, Ipoh (Malaysia) and an Honorary Professor at the University of Rwanda College of Medicine & Health Sciences, Kigali (Rwanda). He also served as a Professor of Pathology at the Lake Erie College of Osteopathic Medicine (LECOM) at Erie, Pennsylvania (U.S.A.) and at Saba University School of Medicine (Dutch Caribbean), as well as an Assistant Professor of Oral Medicine at the Harvard School of Dental Medicine. His research has focused on understanding phosphate and vitamin D regulation in health and disease, and his clinical interest is renal pathology. Dr. Razzaque is a recipient of an R01 grant as a Principal Investigator from the National Institute of Health (U.S.A.).
作者簡介(中文翻譯)
穆罕默德·S·拉扎克博士目前是德克薩斯州里奧格蘭德谷大學（UTRGV）病理學教授，位於德克薩斯州埃丁堡（美國）。他在日本長崎大學獲得病理學博士學位（Ph.D.），並持有孟加拉吉大港大學的醫學學位（M.B.B.S.）。拉扎克博士是哈佛牙醫學院口腔健康政策與流行病學系的訪問教授（美國波士頓）、哈薩克-土耳其國際大學（哈薩克斯坦土庫斯坦）、安特衛普大學（比利時安特衛普）、阿爾法拉比哈薩克國立大學（哈薩克斯坦阿拉木圖）、馬來西亞怡保的吉隆坡皇家醫學院大學，以及盧旺達醫學與健康科學學院的名譽教授（盧旺達基加利）。他曾擔任賓夕法尼亞州伊利的伊利湖骨科醫學學院（LECOM）病理學教授，以及荷蘭加勒比海的薩巴大學醫學院教授，並在哈佛牙醫學院擔任口腔醫學助理教授。他的研究專注於理解磷酸鹽和維生素D在健康與疾病中的調節，其臨床興趣為腎病理學。拉扎克博士是美國國立衛生研究院（NIH）R01計畫的首席研究員獲獎者。
