Bioorthogonal Reactions: Advances and Applications in Chemical Biology and Biomedicine
暫譯: 生物正交反應：化學生物學與生物醫學的進展與應用

Vrábel, Milan, Mikula, Hannes

Bioorthogonal Reactions: Advances and Applications in Chemical Biology and Biomedicine
  • 出版商: Springer
  • 出版日期: 2026-01-03
  • 售價: $15,130
  • 貴賓價: 9.5 折 $14,374
  • 語言: 英文
  • 頁數: 352
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 3032098203
  • ISBN-13: 9783032098207
  • 相關分類: 化學 Chemistry

    • 海外代購書籍(需單獨結帳)

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商品描述

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.

Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

商品描述(中文翻譯)

該系列《當前化學主題系列》（Topics in Current Chemistry Collections）呈現了期刊《當前化學主題》（Topics in Current Chemistry）中的關鍵評論，並以主題卷的形式組織。其涵蓋範圍包括化學科學的所有領域，並涉及與生物學、醫學和材料科學等相關學科的交界處。每個主題卷的目標是為非專業讀者（無論是在學術界還是產業界）提供對新興研究領域的全面見解，這些領域對更廣泛的科學觀眾具有興趣。

每篇評論都對該主題的一個方面進行了批判性調查，並將其置於整個卷的背景中。過去5到10年中最重要的發展將通過選定的例子來展示所討論的原則。這些內容並不旨在成為該領域的全面總結或包含大量數據，而是應該是概念性的，專注於方法論思維，使非專業讀者能夠理解所呈現的信息。貢獻還提供了該領域未來潛在發展的展望。

作者簡介

Since 2014, Milan Vrábel has led the Chemistry of Bioconjugates group at IOCB Prague. His research focuses on developing and applying bioorthogonal reactions to study, visualize, and manipulate biological systems. Situated at the intersection of chemistry and biology, his group uses chemical tools to enhance our understanding of complex biological processes. The lab also works on translating its discoveries into practical uses. Milan Vrábel received an ERC Starting Grant to develop innovative strategies for labeling and studying bioconjugates, resulting in a highly efficient method for chemically re-engineering cell surfaces and adjusting their properties. The potential of this approach in immunotherapy and related fields was further investigated with an ERC Proof of Concept grant. The team continues to improve these techniques and expand their application to a wider range of biomedical challenges.

Hannes Mikula received his Ph.D. from TU Wien in 2014. Inspired by bioorthogonal chemistry, he then joined the lab of Prof. Ralph Weissleder at the Massachusetts General Hospital & Harvard Medical School as a postdoctoral Schrödinger fellow (Austrian Science Fund, FWF). In 2016, Hannes returned to TU Wien as principal investigator and has led the 'Molecular Chemistry & Chemical Biology' group since 2018. From 2021 to 2022, he was Assistant Professor (Tenure Track), and after completing his 'Habilitation' (venia docendi), he became Associate Professor in January 2023, before being promoted to Full Professor of Chemical Biology in October 2023. His team mainly focuses on the development of bioorthogonal tools and technologies for chemical biology, medicinal chemistry and biomedical research. Hannes was awarded a START grant by the FWF in 2021 and an ERC Starting Grant in 2022, aiming for bioorthogonal strategies to navigate and control the function of molecules in cellular environments.

作者簡介(中文翻譯)

自2014年以來，Milan Vrábel 在布拉格的IOC生物化學研究所領導生物共軛化學組。他的研究專注於開發和應用生物正交反應，以研究、可視化和操控生物系統。位於化學與生物學的交叉點，他的團隊利用化學工具來增進我們對複雜生物過程的理解。該實驗室還致力於將其發現轉化為實際應用。Milan Vrábel 獲得了歐洲研究委員會（ERC）起始資助，以開發創新的標記和研究生物共軛物的策略，從而產生了一種高效的化學重組細胞表面及調整其性質的方法。這種方法在免疫療法及相關領域的潛力進一步通過ERC概念驗證資助進行了研究。該團隊持續改進這些技術，並擴展其在更廣泛生物醫學挑戰中的應用。

Hannes Mikula 於2014年在維也納科技大學（TU Wien）獲得博士學位。受到生物正交化學的啟發，他隨後加入麻省總醫院和哈佛醫學院的Ralph Weissleder教授實驗室，擔任奧地利科學基金（FWF）贊助的Schrödinger博士後研究員。2016年，Hannes回到維也納科技大學擔任主要研究員，自2018年以來領導「分子化學與化學生物學」小組。從2021年到2022年，他擔任助理教授（終身職追蹤），並在完成其「Habilitation」（venia docendi）後，於2023年1月成為副教授，並於2023年10月晉升為化學生物學的正教授。他的團隊主要專注於為化學生物學、藥物化學和生物醫學研究開發生物正交工具和技術。Hannes於2021年獲得FWF的START資助，並於2022年獲得ERC起始資助，旨在開發生物正交策略以導航和控制細胞環境中分子的功能。

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