Organoids for Preclinical Disease Modeling and Personalized Medicine
暫譯: 器官類器官在臨床前疾病模型與個人化醫療中的應用

Özge Sezin Somuncu is the Organoid Center Director and Senior Scientist in the Department of Radiation Oncology at Dana-Farber Cancer Institute. Her research focuses on cancer biology, with special expertise in patient-derived organoids, DNA damage and repair mechanisms (notably replication stress, USP1 and PARG pathways), and precision oncology. She earned her PhD from Yeditepe University and has held academic positions including Assistant Professor at Bahçeşehir University. Her recent work has concentrated on identifying functional biomarkers for drug sensitivity in ovarian cancer models. She has authored numerous peer-reviewed publications, contributed to patent applications, and currently leads collaborative translational projects aimed at improving therapeutic strategies. She currently leads and supports organoid-based translational research, oversees collaborative studies between lab researchers and clinicians and helps integrate organoids into preclinical drug development pipelines.

Özge Sezin Somuncu 是 Dana-Farber 癌症研究所放射腫瘤學系的器官類似物中心主任及高級科學家。她的研究專注於癌症生物學，特別專長於患者衍生的器官類似物、DNA 損傷與修復機制（特別是複製壓力、USP1 和 PARG 路徑）以及精準腫瘤學。她在 Yeditepe 大學獲得博士學位，並曾擔任 Bahçeşehir 大學的助理教授。她最近的工作集中於識別卵巢癌模型中藥物敏感性的功能性生物標記。她已發表多篇經過同行評審的論文，參與專利申請，並目前領導協作轉譯項目，旨在改善治療策略。她目前主導並支持基於器官類似物的轉譯研究，監督實驗室研究人員與臨床醫生之間的合作研究，並協助將器官類似物整合進入臨床前藥物開發流程。