Reactive Oxygen Species in Metabolic Inflammation
暫譯: 代謝性發炎中的活性氧物種
Ashique, Sumel, Mishra, Neeraj
- 出版商: Springer
- 出版日期: 2026-02-07
- 售價: $10,150
- 貴賓價: 9.5 折 $9,642
- 語言: 英文
- 頁數: 536
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 3032117518
- ISBN-13: 9783032117519
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商品描述
Reactive oxygen species (ROS)-mediated inflammation plays a critical role in the onset and progression of various metabolic disorders, including obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD). Dysregulated ROS production leads to oxidative stress, which triggers chronic low-grade inflammation, disrupting cellular homeostasis and metabolic functions. This pathological interplay exacerbates insulin resistance, lipid accumulation, and mitochondrial dysfunction, creating a vicious cycle of metabolic dysregulation. Understanding the molecular mechanisms behind ROS-mediated inflammation is crucial for developing targeted therapeutic interventions to break this cycle and mitigate disease progression.
This comprehensive book bridges the gap between fundamental molecular insights and translational therapeutic strategies. It begins by delving into the signaling pathways involved, such as NF-κB and Nrf2, and highlighting the role of key players like mitochondria and antioxidant systems. Later chapters explore emerging therapeutic approaches, including postbiotics, natural antioxidants, and pharmacological agents, offering practical solutions for managing metabolic disorders. By addressing this critical intersection of inflammation, oxidative stress, and metabolism, this book is a valuable guide for researchers, clinicians, and healthcare professionals who aim to tackle the global burden of metabolic diseases effectively.
商品描述(中文翻譯)
反應性氧種（Reactive oxygen species, ROS）介導的炎症在各種代謝疾病的發生和進展中扮演著關鍵角色，包括肥胖、糖尿病和非酒精性脂肪肝病（NAFLD）。不當的ROS產生導致氧化壓力，進而觸發慢性低度炎症，擾亂細胞的穩態和代謝功能。這種病理性相互作用加劇了胰島素抵抗、脂質積累和線粒體功能障礙，形成代謝失調的惡性循環。了解ROS介導的炎症背後的分子機制對於開發針對性的治療干預措施以打破這一循環並減緩疾病進展至關重要。
這本綜合性的書籍彌合了基本分子見解與轉化治療策略之間的鴻溝。它首先深入探討了相關的信號通路，如NF-κB和Nrf2，並強調了線粒體和抗氧化系統等關鍵角色。後面的章節探討了新興的治療方法，包括後生物製劑（postbiotics）、天然抗氧化劑和藥理學劑，提供了管理代謝疾病的實用解決方案。通過解決炎症、氧化壓力和代謝之間的這一關鍵交集，本書是研究人員、臨床醫生和醫療專業人員的寶貴指南，旨在有效應對全球代謝疾病的負擔。
作者簡介
Sumel Ashique has been working as an assistant professor at Department of Pharmaceutical Technology, Bharat Technology, Uluberia-711316, West Bengal, India. He has knowledge in drug delivery, nanotechnology and targeted treatment strategy. Currently he has edited 18+ books under CRC Press, Taylor and Francis, Wiley, Nova Science and Springer. Recently, honored to be in World Top 2% Scientists by prestigious Stanford University, CA, USA and Elsevier in 2025.
Dr. Neeraj Mishra is working as Professor in Amity Institute of Pharmacy, Gwalior since July 2019. He has around twenty years of teaching and research experience. He has more than 150 publications of International and National repute in recent concepts of novel drug delivery systems, localized drug delivery, targeted and controlled drug delivery etc. He has also written 25 Books and 45 book chapters in Elsevier, Bentham, Springer and Wiley Publication etc. Recently, honored to be in World Top 2% Scientists by prestigious Stanford University, CA, USA and Elsevier in 2025.
作者簡介(中文翻譯)
Sumel Ashique 目前在印度西孟加拉邦 Uluberia-711316 的 Bharat Technology 藥物技術系擔任助理教授。他在藥物傳遞、奈米技術和靶向治療策略方面具有專業知識。目前，他已編輯超過 18 本書籍，出版於 CRC Press、Taylor and Francis、Wiley、Nova Science 和 Springer。最近，他榮獲美國加州史丹佛大學及 Elsevier 頒發的 2025 年全球前 2% 科學家榮譽。
Neeraj Mishra 博士自 2019 年 7 月以來在 Amity Institute of Pharmacy 擔任教授。他擁有約二十年的教學和研究經驗。他在新型藥物傳遞系統、局部藥物傳遞、靶向和控制藥物傳遞等方面擁有超過 150 篇國際和國內知名的出版物。他還在 Elsevier、Bentham、Springer 和 Wiley 等出版商撰寫了 25 本書和 45 章書籍。最近，他榮獲美國加州史丹佛大學及 Elsevier 頒發的 2025 年全球前 2% 科學家榮譽。
