商品描述
Advanced Extraction Techniques: Anti-Doping & Forensic Approaches for Drug Testing delivers a comprehensive and practical guide to the modern extraction strategies essential for detecting drugs and toxic agents in complex biological matrices. Emphasizing the foundational role of sample preparation, this book shows how carefully optimized extraction methods shape the accuracy, sensitivity, and legal defensibility of toxicological results across forensic, clinical, and anti-doping environments. The book explores a broad range of biological specimens, from routine matrices such as blood, urine, and plasma to alternative samples including hair, oral fluid, nails, vitreous humor, and meconium. It also addresses key analytical challenges such as matrix effects, protein binding, phospholipid interference, and analyte instability. Readers gain clear insight into how extraction influences downstream performance in LC-MS/MS and other related techniques. Key highlights include: - Comprehensive discussion of liquid-liquid extraction, solid-phase extraction, microextraction techniques etc. - Practical guidance for enhancing detection of amphetamines, antihistamines, NSAIDs, corticosteroids, anabolic steroids, peptides, bisphosphonates, ITPP, and quaternary ammonium drugs - Detailed workflows that connect extraction decisions to robust analytical outcomes. - Focused coverage of anti-doping applications aligned with international testing and accreditation standards. Ideal for forensic toxicologists, analytical chemists, pharmacologists, anti-doping specialists, and graduate students, this volume bridges scientific principles with applied practice. By demonstrating how optimized extraction boosts analytical reliability, reduces variability, and extends detection windows, the book strengthens the scientific foundation of forensic investigations, clinical diagnostics, public health monitoring, and sports medicine.
商品描述(中文翻譯)
《先進的萃取技術：反興奮劑與法醫方法 於藥物測試》提供了一本全面且實用的指南，介紹現代萃取策略，這些策略對於在複雜生物基質中檢測藥物和有毒物質至關重要。本書強調樣本準備的基礎性角色，展示了如何通過精心優化的萃取方法來影響法醫、臨床和反興奮劑環境中毒理學結果的準確性、敏感性和法律可辯護性。
本書探討了各種生物樣本，從常規基質如血液、尿液和血漿，到包括頭髮、口腔液、指甲、玻璃體和胎便等替代樣本。它還針對關鍵的分析挑戰，如基質效應、蛋白質結合、磷脂干擾和分析物不穩定性進行了討論。讀者將清楚了解萃取如何影響LC-MS/MS及其他相關技術的下游性能。
主要亮點包括：
- 涵蓋液-液萃取、固相萃取、微萃取技術等的全面討論。
- 提供增強安非他命、抗組胺藥、非類固醇抗炎藥、皮質類固醇、合成類固醇、肽類、雙磷酸鹽、ITPP和季銨藥物檢測的實用指導。
- 詳細的工作流程，將萃取決策與穩健的分析結果相連接。
- 專注於與國際測試和認證標準相一致的反興奮劑應用的覆蓋。
本書非常適合法醫毒理學家、分析化學家、藥理學家、反興奮劑專家和研究生，將科學原則與應用實踐相結合。通過展示如何優化萃取以提高分析可靠性、減少變異性和延長檢測窗口，本書加強了法醫調查、臨床診斷、公共健康監測和運動醫學的科學基礎。
作者簡介
Dr. Abdul Khader Karakka Kal is a senior researcher and Head of the Scientific Research Section at the Equine Forensic Unit, Central Veterinary Research Laboratory, Dubai. He holds a Ph.D. in Chemistry and brings nearly twenty years of experience in analytical chemistry, forensic toxicology, discovery chemistry, and anti-doping science. His work focuses on improving the detection of drugs and emerging performance-enhancing substances in biological samples. Dr. Karakka Kal has authored over 40 peer-reviewed publications in high-impact journals, several of which have been recognized as Top Cited Articles. His research includes the development of advanced extraction methods, mass spectrometric applications, and metabolic investigations of novel performance-enhancing substances. His expertise uniquely positions him to bridge the gap between method development and real-world forensic and anti-doping applications. By combining deep technical knowledge with practical laboratory leadership, Dr. Kal brings a comprehensive perspective to advancing extraction techniques for forensic and clinical toxicology. Dr. Michael Subhahar serves as Chief Analyst at the Equine Forensic Unit, Central Veterinary Research Laboratory, Dubai, bringing over 30 years of expertise in forensic racing chemistry. He earned his Ph.D. in Forensic Science from the University of Central Lancashire, U.K., and specializes in method development, screening, detection, and confirmatory analysis of performance-enhancing substances in horses and camels. Dr. Subhahar manages a team analyzing more than 13,500 racehorse samples annually using advanced LC/MS, GC/MS, ICP/MS, and QTOF-MS platforms. He has been instrumental in establishing anti-doping laboratories, including the Camel Forensic Laboratory, and has led pioneering research on metabolic studies in race animals. His scholarly contributions include over 25 peer-reviewed publications in Rapid Communications in Mass Spectrometry, Drug Testing and Analysis, and Journal of Analytical Toxicology. A Fellow of the Association of Biomedical Scientists and a member of the Association of Official Racing Chemists, Dr. Subhahar is internationally recognized for advancing doping control in veterinary sports. Dr. Tajudheen K. Karatt is an accomplished scientist with over 19 years of expertise in Racing Chemistry and Discovery Drug Chemistry. He currently serves as Deputy Technical Manager at the Equine Forensic Unit, Central Veterinary Research Laboratory, Dubai, where he oversees technical and scientific operations, and leads analytical method development, validation, and forensic research. Dr. Karatt holds a Ph.D. in Chemistry from Bharathidasan University, India and has a distinguished academic record, earning First Rank and Gold Medals in both his bachelor and master degree in Industrial Chemistry. His professional journey includes significant roles at Biocon- Bristol Myers Squibb Research Center in India, where he specialized in medicinal and synthetic chemistry before transitioning to forensic analytical science in the UAE. Dr. Karatt is a Professional Member of the Association of Official Racing Chemists (AORC) and has contributed to over 30 research publications in reputed international journals. His career is marked by numerous awards, international trainings, and certifications, making him a recognized leader in his field.
作者簡介(中文翻譯)
阿卜杜勒·卡德爾·卡拉卡·卡爾博士是迪拜中央獸醫研究實驗室馬匹法醫單位的高級研究員及科學研究部門負責人。他擁有化學博士學位，並在分析化學、法醫毒理學、發現化學及反興奮劑科學方面擁有近二十年的經驗。他的工作重點在於改善生物樣本中藥物及新興表現增強物質的檢測。卡拉卡·卡爾博士在高影響力期刊上發表了超過40篇經過同行評審的論文，其中幾篇被認可為高引用文章。他的研究包括先進提取方法的開發、質譜應用及新型表現增強物質的代謝研究。他的專業知識使他能夠有效地將方法開發與實際的法醫及反興奮劑應用相結合。通過將深厚的技術知識與實際的實驗室領導能力相結合，卡爾博士為推進法醫及臨床毒理學的提取技術提供了全面的視角。 邁克爾·蘇巴哈博士擔任迪拜中央獸醫研究實驗室馬匹法醫單位的首席分析師，擁有超過30年的法醫賽馬化學專業知識。他在英國中央蘭開夏大學獲得法醫科學博士學位，專注於馬匹和駱駝中表現增強物質的檢測、篩選及確認分析的技術開發。蘇巴哈博士管理一個團隊，每年分析超過13,500個賽馬樣本，使用先進的LC/MS、GC/MS、ICP/MS和QTOF-MS平台。他在建立反興奮劑實驗室方面發揮了重要作用，包括駱駝法醫實驗室，並在賽馬動物的代謝研究中領導了開創性研究。他的學術貢獻包括在《質譜快速通訊》、《藥物檢測與分析》和《分析毒理學期刊》上發表的超過25篇經過同行評審的論文。作為生物醫學科學家協會的會員及官方賽馬化學家協會的成員，蘇巴哈博士在推進獸醫運動中的興奮劑控制方面享有國際聲譽。 塔尤丁·K·卡拉特博士是一位成就卓著的科學家，擁有超過19年的賽馬化學和新藥化學專業知識。他目前擔任迪拜中央獸醫研究實驗室馬匹法醫單位的副技術經理，負責技術和科學運作，並領導分析方法的開發、驗證及法醫研究。卡拉特博士在印度巴拉特迪薩大學獲得化學博士學位，並在工業化學的學士和碩士學位中均獲得第一名和金獎，擁有卓越的學術成就。他的職業生涯包括在印度Biocon-布里斯托-邁爾斯·史奧比研究中心的重要角色，專注於藥物化學和合成化學，然後轉向阿聯酋的法醫分析科學。卡拉特博士是官方賽馬化學家協會（AORC）的專業會員，並在多個國際知名期刊上發表了超過30篇研究論文。他的職業生涯中獲得了眾多獎項、國際培訓和認證，使他成為該領域的公認領袖。
