Mechanotransduction and Mechanosensing: Roles and Effects on Biological Systems Under Physiological and Pathological Conditions
暫譯: 機械轉導與機械感知：在生理與病理條件下對生物系統的角色與影響
Kloc, Malgorzata, Wosik, Jarek
- 出版商: Springer
- 出版日期: 2026-06-02
- 售價: $8,900
- 貴賓價: 9.5 折 $8,455
- 語言: 英文
- 頁數: 455
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 303219508X
- ISBN-13: 9783032195081
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相關分類:
靜力學 Engineering-mechanics
海外代購書籍(需單獨結帳)
商品描述
This volume explores how cells and tissues sense and respond to mechanical forces, revealing their roles in health and disease, and presenting the latest models and therapeutic strategies in the field of mechanobiology.
All living organisms are subject to mechanical forces, such as tension, compression, shear, torsion, bending and friction. Organisms and their components must sense and respond to these forces. Cells, cellular organelles, tissues and organs detect the physical properties of their internal and external environments, including spatial topography, substrate rigidity, compactness and porosity. After sensing these mechanical cues, they transmit the information to their structural and molecular components. These components then adjust the cell's structure, molecular composition, gene expression, signalling pathways, spatial arrangement, cell cycle, longevity, and other functions.
The book looks at new developments in our understanding of these processes in various cells, describes the roles of mechanosensing and mechanotransduction in disease, and presents novel mechanosensation models and therapeutic approaches.
商品描述(中文翻譯)
本卷探討細胞和組織如何感知和回應機械力，揭示它們在健康和疾病中的角色，並介紹機械生物學領域的最新模型和治療策略。
所有生物體都受到機械力的影響，例如拉伸、壓縮、剪切、扭轉、彎曲和摩擦。生物體及其組成部分必須感知並回應這些力量。細胞、細胞器、組織和器官檢測其內部和外部環境的物理特性，包括空間地形、基質剛性、緊密度和孔隙率。在感知這些機械信號後，它們將信息傳遞給其結構和分子組件。這些組件隨後調整細胞的結構、分子組成、基因表達、信號通路、空間排列、細胞週期、壽命及其他功能。
本書探討了我們對這些過程在各種細胞中理解的新進展，描述了機械感知和機械轉導在疾病中的角色，並介紹了新穎的機械感知模型和治療方法。
作者簡介
Malgorzata Kloc: Prior to completing her postdoctoral training in Canada, Dr. Kloc was a tenured Associate Professor in the Department of Zoology at the University of Warsaw, Poland. She also served as a Research Associate in the Department of Biology at Carleton University in Ottawa, Canada. While completing her postdoctoral training, Dr. Kloc earned the AHFMR Research Award from the University of Calgary and the MRC Biotechnology Training Award from Dalhousie University. She joined the University of Texas M.D. Anderson Cancer Center as a Research Scientist in the Department of Molecular Genetics in 1987, and became an Associate Professor in the Department of Biochemistry and Molecular Biology there in 2006. Dr. Kloc joined the Houston Methodist Research Institute in 2008. Currently, Dr. Kloc is the Weill Cornell Professor of Cell and Molecular Biology at The Houston Methodist Hospital.
Jarek Wosik: After completing his PhD at the Institute of Physics, Polish Academy of Sciences in Poland in 1986, he worked as a Research Scientist at the Research and Development Center for Semiconductors, the Institute of Electron Technology, the Institute of Electronic Materials Technology, and at the Institute of Physics, Polish Academy of Science. In 1987, he moved to Houston and worked at the Department of Electrical and Computer Engineering, University of Houston, and Texas Heart Institute. In 2003, he became a Research Professor at the Department of Electrical & Computer Engineering and Texas Center for Superconductivity, University of Houston. He is a member of the American Physical Society, Material Research Society, and International Society for Magnetic Resonance in Medicine. Since 2001, he has also been a Director of High Frequency Bioengineering Laboratory. His scientific interests include designing magnetic nanoconstructs for the imaging and hyperthermia of tumor cells and neovasculature, water extraction from lunar polar ice by microwave heating, development of noninvasive sensors of metabolic activity, and electromagnetic time-reversal techniques for targeted radiofrequency cancer therapy. He also closely collaborates with Dr. M. Kloc on the magnetic field-induced cytoskeleton alteration to prevent the rejection of transplanted organs.
作者簡介(中文翻譯)
Malgorzata Kloc：在加拿大完成博士後訓練之前，Kloc 博士曾擔任波蘭華沙大學動物學系的終身副教授。她還曾在加拿大渥太華的卡爾頓大學生物學系擔任研究助理。在完成博士後訓練期間，Kloc 博士獲得了卡爾加里大學的 AHFMR 研究獎和達爾豪斯大學的 MRC 生物技術培訓獎。1987 年，她加入德克薩斯大學 M.D. 安德森癌症中心，擔任分子遺傳學系的研究科學家，並於 2006 年成為生物化學與分子生物學系的副教授。Kloc 博士於 2008 年加入休士頓衛理醫院研究所。目前，Kloc 博士是休士頓衛理醫院的韋爾醫學院細胞與分子生物學教授。
Jarek Wosik：在 1986 年於波蘭科學院物理研究所完成博士學位後，他在半導體研究與發展中心、電子技術研究所、電子材料技術研究所以及波蘭科學院物理研究所擔任研究科學家。1987 年，他移居休士頓，並在休士頓大學電機與計算機工程系及德克薩斯心臟研究所工作。2003 年，他成為休士頓大學電機與計算機工程系及德克薩斯超導中心的研究教授。他是美國物理學會、材料研究學會及國際醫學磁共振學會的成員。自 2001 年以來，他還擔任高頻生物工程實驗室的主任。他的科學興趣包括設計用於腫瘤細胞和新生血管成像及超熱治療的磁性納米結構、通過微波加熱從月球極地冰中提取水、開發非侵入性代謝活動傳感器，以及用於靶向射頻癌症治療的電磁時間反轉技術。他還與 M. Kloc 博士密切合作，研究磁場誘導的細胞骨架改變，以防止移植器官的排斥反應。
