Carbonic Anhydrase Inhibitors
暫譯: 碳酸酐酶抑制劑

Neera Raghav
Dr. Raghav completed her PhD in Chemistry and has dedicated 30 years to the teaching profession. She has been working as a Professor since 2011 in the Department of Chemistry at Kurukshetra University, Kurukshetra, India. Her research interests include the synthesis and evaluation of enzyme inhibitors. Several of her research papers have been published in leading national and international journals. Her research group has filed a number of patents in the field of enzyme inhibitors and drug delivery systems--one has been granted, and others are currently under review.

Claudiu T. Supuran
Dr. Supuran has been a Professor of Medicinal and Pharmaceutical Chemistry at the University of Florence, Italy, since 1995. He completed his PhD at the University of Bucharest, Romania, and subsequently worked as a visiting scholar at the University of Florida, Gainesville, USA, and at Griffith University, Brisbane, Australia. He has also served as a visiting professor at the University of La Plata, Argentina, and at the University of New South Wales, Sydney, Australia.

His main research interest lies in the medicinal chemistry and biochemistry of carbonic anhydrases, a field in which he has made significant contributions. These include the design of numerous novel classes of enzyme inhibitors and activators, elucidation of their mechanisms of action at the molecular level, discovery of new isoforms and their roles in various diseases (such as cancer, obesity, epilepsy, neuropathic pain, and cognitive disorders), as well as the discovery and characterization of carbonic anhydrases from diverse organisms (including bacteria, fungi, corals, and non-human vertebrates).

Additional research interests include the X-ray crystallography of metalloenzymes, heterocyclic chemistry, the chemistry of sulfonamides, metal-based drugs, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives. He has published more than 2,300 papers in these areas, and his Hirsch index is 170. One of the compounds discovered in his laboratory (SLC-0111) is currently in Phase II clinical trials for the treatment of advanced metastatic solid tumors.

尼拉·拉哈夫
拉哈夫博士獲得化學博士學位，並在教學職業上奉獻了30年。自2011年以來，她一直在印度庫魯克舍特拉大學的化學系擔任教授。她的研究興趣包括酶抑制劑的合成與評估。她的多篇研究論文已發表於國內外知名期刊。她的研究團隊已在酶抑制劑和藥物傳遞系統領域申請了多項專利，其中一項已獲得批准，其他則正在審核中。

克勞迪烏·T·蘇普蘭
蘇普蘭博士自1995年以來一直擔任意大利佛羅倫斯大學的藥物與藥學化學教授。他在羅馬尼亞布加勒斯特大學獲得博士學位，隨後在美國佛羅里達州蓋恩斯維爾的佛羅里達大學和澳大利亞布里斯班的格里菲斯大學擔任訪問學者。他還曾在阿根廷拉普拉塔大學和澳大利亞新南威爾士大學擔任訪問教授。

他的主要研究興趣在於碳酸酐酶的藥物化學和生物化學，這是一個他做出重大貢獻的領域。這些貢獻包括設計多種新型酶抑制劑和激活劑，闡明其在分子層面的作用機制，發現新的同種型及其在各種疾病（如癌症、肥胖、癲癇、神經性疼痛和認知障礙）中的角色，以及從多種生物（包括細菌、真菌、珊瑚和非人類脊椎動物）中發現和表徵碳酸酐酶。

其他研究興趣包括金屬酶的X射線晶體學、雜環化學、磺胺類化合物的化學、金屬基藥物、環氧合酶、絲氨酸蛋白酶、基質金屬蛋白酶、細菌蛋白酶和氨基酸衍生物。他在這些領域已發表超過2300篇論文，Hirsch指數為170。他的實驗室發現的一種化合物（SLC-0111）目前正在進行第二期臨床試驗，以治療晚期轉移性實體腫瘤。