The Biology of RNA: Long and Small Non-Coding Rnas
暫譯: RNA的生物學：長小非編碼RNA
Haseltine, William A., Patarca, Roberto
- 出版商: Springer
- 出版日期: 2026-08-22
- 售價: $4,300
- 貴賓價: 9.5 折 $4,085
- 語言: 英文
- 頁數: 401
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 3032302692
- ISBN-13: 9783032302694
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相關分類:
生物資訊 Bioinformatics
海外代購書籍(需單獨結帳)
商品描述
In the early stages of an RNA revolution, the potential of RNA technology to transform human and veterinary medicine, agriculture, and industry, is emergent in much the same way as the advent of recombinant DNA in the 1980s, which created and disrupted products and markets. The revolution has been heralded by the realization that RNA plays a more fundamental role in biology than that reflected in the classical central molecular biology dogma--DNA to RNA to protein to phenotype. The new consensus is that RNA plays a more fundamental role in biology, directly regulating protein function and phenotype. Non-protein coding RNA accounts for more than 95% of the transcriptional output of human, animal, and plant genomes and regulates gene expression, chromatin remodeling, and cellular growth. The number of noncoding RNAs exceeds that of protein-coding RNAs, including inherited changes, significantly increasing the number of inherited genes.
This textbook offers a comprehensive overview of the biology of RNA and is a companion volume to The Biology of RNA: The Fundamentals, The Practical Applications of RNA: Medicine, and The Practical Applications of RNA: Agriculture and Industry. Chapters are structured to enhance learning and retention with the use of overviews, learning objectives, and clearly highlighted key concepts, definitions, and points to remember. Chapters are rounded out with case studies, exercises, and quizzes to encourage readers to think and apply new knowledge. Capturing the state of research and offering insight on emerging topics and future knowledge trends, this textbook is a pivotal resource for advanced students and researchers in molecular biology, and any reader interested in learning more about this rapidly advancing field.
商品描述(中文翻譯)
在RNA革命的早期階段，RNA技術在改變人類和獸醫醫學、農業及工業方面的潛力，正以與1980年代重組DNA的出現相似的方式浮現，後者創造並顛覆了產品和市場。這場革命的到來是因為人們意識到RNA在生物學中扮演著比傳統的中心分子生物學教條（DNA轉錄為RNA，再轉譯為蛋白質，最後表現為表型）更根本的角色。新的共識是RNA在生物學中扮演著更基本的角色，直接調控蛋白質功能和表型。非蛋白質編碼RNA佔據了人類、動物和植物基因組轉錄產出的95%以上，並調控基因表達、染色質重塑和細胞生長。非編碼RNA的數量超過蛋白質編碼RNA，包括遺傳變化，顯著增加了遺傳基因的數量。
本教科書提供了RNA生物學的全面概述，並作為《RNA生物學：基礎》、《RNA的實際應用：醫學》和《RNA的實際應用：農業與工業》的伴隨卷。各章節的結構旨在通過概述、學習目標以及清晰突出的關鍵概念、定義和要點來增強學習和記憶。章節中還包含案例研究、練習和測驗，以鼓勵讀者思考並應用新知識。本教科書捕捉了研究的現狀，並提供對新興主題和未來知識趨勢的見解，是分子生物學高級學生和研究人員的重要資源，亦適合任何對這一快速發展領域感興趣的讀者。
作者簡介
Dr. Willaiam A. Haseltine, Founder of Human Genome Sciences, Founder and Chair of ACCESS Health International, former Professor at Harvard Medical School and Dana-Farber Cancer Institute. He is the author of more than 200 peer-reviewed articles and Professor of Regenerative Medicine at the Feinstein Institutes for Medical Research. With over 50 years of experience, he has worked extensively with RNA. He co-discovered enhancers during his professional work at the Dana Farber Cancer Institute. Later, as founder and CEO of Human Genome Sciences, the company became the first in the world to isolate a complete set of protein-coding messenger RNAs and hundreds of thousands of other noncoding mRNAs. He continues to work on the fundamental role of RNA in biology and its medical applications.
Dr. Roberto Patarca, MD, PhD is the Chief Medical Officer at ACCESS Health International, former faculty at Harvard Medical School and the University of Miami, and medical device company executive and has published over 100 manuscripts and nine books, served as Editor-in-Chief and Book Series Editor for Haworth Medical Press, and was elected member of the Academy of Sciences of Latin America. Their contributions have sparked progressive dialogues within the scientific community.
作者簡介(中文翻譯)
威廉·A·哈塞爾廷博士（Dr. William A. Haseltine），人類基因組科學公司的創始人，ACCESS Health International的創始人及主席，曾任哈佛醫學院及丹娜法伯癌症研究所的教授。他是200多篇經過同行評審的文章的作者，並且是費恩斯坦醫學研究所再生醫學的教授。擁有超過50年的經驗，他在RNA方面有廣泛的研究。他在丹娜法伯癌症研究所的專業工作中共同發現了增強子（enhancers）。後來，作為人類基因組科學公司的創始人兼首席執行官，該公司成為全球首個分離出完整蛋白質編碼信使RNA（messenger RNAs）及數十萬種其他非編碼mRNA的公司。他持續研究RNA在生物學中的基本角色及其醫學應用。
羅伯托·帕塔卡醫生（Dr. Roberto Patarca），醫學博士、哲學博士，是ACCESS Health International的首席醫療官，曾任哈佛醫學院及邁阿密大學的教職，並在醫療器械公司擔任高管，已發表超過100篇手稿和九本書籍，曾擔任霍沃斯醫學出版社的主編及書系列編輯，並當選為拉丁美洲科學院的成員。他們的貢獻在科學社群中引發了進步的對話。
