Fundamentals of Bioinformatics and Computational Biology: Methods and Exercises in MATLAB (Modeling and Optimization in Science and Technologies)

Gautam B. Singh

  • 出版商: Springer
  • 出版日期: 2014-10-08
  • 售價: $7,610
  • 貴賓價: 9.5$7,230
  • 語言: 英文
  • 頁數: 339
  • 裝訂: Hardcover
  • ISBN: 3319114026
  • ISBN-13: 9783319114026
  • 相關分類: Matlab生物資訊 Bioinformatics
  • 海外代購書籍(需單獨結帳)

商品描述

This book offers comprehensive coverage of all the core topics of bioinformatics, and includes practical examples completed using the MATLAB bioinformatics toolbox™. It is primarily intended as a textbook for engineering and computer science students attending advanced undergraduate and graduate courses in bioinformatics and computational biology. The book develops bioinformatics concepts from the ground up, starting with an introductory chapter on molecular biology and genetics. This chapter will enable physical science students to fully understand and appreciate the ultimate goals of applying the principles of information technology to challenges in biological data management, sequence analysis, and systems biology. The first part of the book also includes a survey of existing biological databases, tools that have become essential in today’s biotechnology research. The second part of the book covers methodologies for retrieving biological information, including fundamental algorithms for sequence comparison, scoring, and determining evolutionary distance. The main focus of the third part is on modeling biological sequences and patterns as Markov chains. It presents key principles for analyzing and searching for sequences of significant motifs and biomarkers. The last part of the book, dedicated to systems biology, covers phylogenetic analysis and evolutionary tree computations, as well as gene expression analysis with microarrays. In brief, the book offers the ideal hands-on reference guide to the field of bioinformatics and computational biology.

商品描述(中文翻譯)

本書全面介紹了生物信息學的所有核心主題,並包含使用MATLAB生物信息學工具箱™完成的實際示例。它主要是為工程和計算機科學專業的本科和研究生生物信息學和計算生物學課程的學生而設計的教科書。本書從基礎開始發展生物信息學概念,首先介紹了分子生物學和遺傳學的基礎知識。這一章將使理科學生能夠充分理解和欣賞將信息技術原則應用於生物數據管理、序列分析和系統生物學挑戰的最終目標。本書的第一部分還包括對現有生物數據庫的調查,這些數據庫已成為當今生物技術研究中不可或缺的工具。本書的第二部分涵蓋了檢索生物信息的方法,包括用於序列比較、評分和確定進化距離的基本算法。第三部分的主要重點是將生物序列和模式建模為馬爾可夫鏈。它介紹了分析和搜索具有重要模式和生物標記的序列的關鍵原則。本書的最後一部分專門介紹了系統生物學,包括親緣分析和演化樹計算,以及使用微陣列進行基因表達分析。總之,本書提供了生物信息學和計算生物學領域的理想實踐參考指南。