DNA Nanotechnology for Cell Research: From Bioanalysis to Biomedicine

Comprehensive coverage of DNA nanotechnology with a focus on its biomedical applications in disease diagnosis, gene therapy, and drug delivery

Bringing together multidisciplinary aspects of chemical, material, and biological engineering, DNA Nanotechnology for Cell Research: From Bioanalysis to Biomedicine presents an overview of DNA nanotechnology with emphasis on a variety of different applications in cell research and engineering, covering a unique collection of DNA nanotechnology for fundamental research and engineering of living cells, mostly in cellulo and in vivo, for the first time. Broad coverage of this book ranges from pioneering concepts of DNA nanotechnology to cutting-edge reports regarding the use of DNA nanotechnology for fundamental cell science and related biomedical engineering applications in sensing, bioimaging, cell manipulation, gene therapy, and drug delivery.

The text is divided into four parts. Part I surveys the progress of functional DNA nanotechnology tools for cellular recognition. Part II illustrates the use of DNA-based biochemical sensors to monitor and image intracellular molecules and processes. Part III examines the use of DNA to regulate biological functions of individual cells. Part IV elucidates the use of DNA nanotechnology for cell-targeted medical applications.

Sample topics covered in DNA Nanotechnology for Cell Research include:

• Selections and applications of functional nucleic acid toolkits, including DNA/RNA aptamers, DNAzymes, and riboswitches, for cellular recognition, metabolite detection, and liquid biopsy.
• Developing intelligent DNA nanodevices implemented in living cells for amplified cell imaging, smart intracellular sensing, and in cellulo programmable biocomputing.
• Harnessing dynamic DNA nanotechnology for non-genetic cell membrane engineering, receptor signaling reprogramming, and cellular behavior regulation.
• Construction of biocompatible nucleic acid nanostructures as precisely controlled vehicles for drug delivery, immunotherapy, and tissue engineering.

Providing an up-to-date tutorial style overview along with a highly valuable in-depth perspective, DNA Nanotechnology for Cell Research is an essential resource for the entire DNA-based nanotechnology community, including analytical chemists, biochemists, materials scientists, and bioengineers.

細胞研究的DNA納米技術

全面介紹DNA納米技術，重點關注其在疾病診斷、基因治療和藥物傳遞方面的生物醫學應用

結合化學、材料和生物工程的多學科方面，《從生物分析到生物醫學的細胞研究的DNA納米技術》概述了DNA納米技術，重點介紹了細胞研究和工程中不同應用的DNA納米技術，首次全面涵蓋了對活體細胞的基礎研究和工程的獨特集合，主要是在細胞內和體內進行。本書廣泛涵蓋了DNA納米技術的先驅概念，以及關於在感知、生物成像、細胞操作、基因治療和藥物傳遞等基礎細胞科學和相關生物醫學工程應用中使用DNA納米技術的尖端報告。

本文分為四個部分。第一部分概述了功能性DNA納米技術工具在細胞識別方面的進展。第二部分介紹了使用基於DNA的生化傳感器監測和成像細胞內分子和過程的方法。第三部分探討了使用DNA調節個別細胞生物功能的方法。第四部分闡明了使用DNA納米技術進行針對細胞的醫學應用的方法。

《細胞研究的DNA納米技術》涵蓋的示例主題包括：

• 功能性核酸工具包的選擇和應用，包括DNA/RNA適配體、DNA酶和核酸開關，用於細胞識別、代謝物檢測和液體活檢。
• 開發智能DNA納米裝置，用於活體細胞中的放大細胞成像、智能細胞內感測和細胞內可編程生物計算。
• 利用動態DNA納米技術進行非遺傳性細胞膜工程、受體信號重編程和細胞行為調節。
• 構建生物相容性核酸納米結構，作為精確控制的藥物傳遞、免疫治療和組織工程載體。

提供最新的教程風格概述和深入的觀點，《細胞研究的DNA納米技術》是整個基於DNA的納米技術社區的重要資源，包括分析化學家、生物化學家、材料科學家和生物工程師。

Zhou Nie is Professor at the College of Chemistry and Chemical Engineering, Hunan University, China. His research is focused on the development of new nucleic acid nanotechnology-based toolkits for detection and regulation of key factors in crucial biological events, such as cellular signal transduction and transcription regulation. He was awarded by the National Science Fund for Distinguished Young Scholars in 2017, the WuXi AppTec Life Chemistry Research Award in 2022, and the Chinese Chemical Society Young Chemist Award in 2015.

周聶是中國湖南大學化學與化學工程學院的教授。他的研究專注於開發基於核酸納米技術的新型工具，用於檢測和調控關鍵生物事件中的重要因子，例如細胞信號傳導和轉錄調控。他於2017年獲得國家自然科學基金傑出青年科學家獎，2022年獲得無錫華大基因生命化學研究獎，以及2015年獲得中國化學學會青年化學家獎。