Handbook of Single-Cell Technologies
暫譯: 單細胞技術手冊

Santra, Tuhin Subhra, Tseng, Fan-Gang

Handbook of Single-Cell Technologies
  • 出版商: Springer
  • 出版日期: 2021-10-29
  • 售價: $27,100
  • 貴賓價: 9.5 折 $25,745
  • 語言: 英文
  • 頁數: 1096
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 9811089523
  • ISBN-13: 9789811089527
  • 相關分類: 生物資訊 Bioinformatics

    • 海外代購書籍(需單獨結帳)

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商品描述

This book provides a brief overview of single-cell analysis using recent advanced technologies.

The different sections cover different aspect of single cell analysis and applications with their advantages, limitations, and future challenges. The book has covered how different physical energies such as optical, electrical, and mechanical energy have been applied for single cell therapy and analysis. The recent advanced micro/nanofluidic devices have been employed for single-cell counting, manipulation, cultivation, separation, isolation, lysis, printing and patterning and host-viral interaction at single-cell level. Various chemical approaches for single-cell analysis have been discussed, such as liposome mediated materials transfer at single-cell and their analysis, discovery of antibody via single-cell, high-throughput screening of antigen-specific antibody-secreting cells, and biomolecular secretion analysis of individual cells. Moreover, different single-cell omics such as genomics, proteomics and transcriptomics have been discussed using microfluidic technologies as well as conventional approaches.

The role of single cell analysis in system biology and biocatalysis have been discussed in detail. The book describes single-cell phenotyping of heterogeneous tissue, stimulation, and instant reaction quenching technology for biochemical kinetic analysis, large scale single-cell assay for the identification of biocatalysts and analytical techniques for single-cell studies in microbiology. The role of single-cell analysis in cancer, such as single-cell adhesion and cancer progression, single-cell technologies for cancer therapy, analytical technology for single cancer cell analysis, and biophysical markers for cancer cell analysis have been discussed. The flow cytometry based high throughput single-cell analysis have been well emphasized. Finally this book has covered single-cell electrophysiology, single-cell sensing and size measurement using mechanical and microwave resonators, molecular force spectroscopy for cell adhesion measurement, micro-tweezers and force microscopy techniques for single-cell mechanobiological analysis, mass spectrometry and acoustic tweezers for single-cell manipulation and analysis.

This book is intended for academic and industrial researchers, undergraduate and graduate students in the fields of biomedical engineering, bio-micro/nanoengineering, and bio-micro/nano fabrication for single-cell analysis. It can be used for courses on bio-MEMS/bio-NEMS, biomicrofluidics, bio-micro/nanofabrications, micro/nanofluidics, biophysics, single cell analysis, bionanotechnology, drug delivery systems and biomedical microdevices. Collective contributions from respected experts, have brought diverse aspects of single-cell technologies in a single hand book. This will benefit researchers and practitioners in the biotechnology industry for different diseases analysis, therapeutics, diagnostics, drug discovery, drug screening etc.

In addition to hard copies, the book will be available online and will often be updated by the authors.

商品描述(中文翻譯)

這本書提供了使用最新先進技術進行單細胞分析的簡要概述。不同的章節涵蓋了單細胞分析及其應用的不同方面，包括其優勢、限制和未來挑戰。本書介紹了不同的物理能量，如光學、電學和機械能量，如何應用於單細胞治療和分析。最近的先進微/納米流體裝置已被用於單細胞計數、操作、培養、分離、隔離、裂解、列印和在單細胞層面上進行的宿主-病毒互動。書中討論了各種化學方法進行單細胞分析，例如在單細胞層面上透過脂質體介導的材料轉移及其分析、通過單細胞發現抗體、抗原特異性抗體分泌細胞的高通量篩選，以及個別細胞的生物分子分泌分析。此外，書中還使用微流體技術和傳統方法討論了不同的單細胞組學，如基因組學、蛋白質組學和轉錄組學。

單細胞分析在系統生物學和生物催化中的角色已詳細討論。本書描述了異質組織的單細胞表型分析、刺激和瞬時反應淬火技術用於生化動力學分析、大規模單細胞測定以識別生物催化劑，以及微生物學中單細胞研究的分析技術。單細胞分析在癌症中的角色，如單細胞黏附和癌症進展、癌症治療的單細胞技術、單個癌細胞分析的分析技術，以及癌細胞分析的生物物理標記也已被討論。基於流式細胞術的高通量單細胞分析得到了充分強調。最後，本書涵蓋了單細胞電生理學、單細胞感測和使用機械和微波共振器進行的尺寸測量、分子力光譜學用於細胞黏附測量、微夾子和力顯微技術用於單細胞機械生物學分析、質譜和聲學夾子用於單細胞操作和分析。

本書旨在為生物醫學工程、生物微/納米工程和生物微/納米製造領域的學術和工業研究人員、本科生和研究生提供參考。它可以用於生物MEMS/生物NEMS、生物微流體學、生物微/納米製造、微/納米流體學、生物物理學、單細胞分析、生物納米技術、藥物傳遞系統和生物醫學微裝置等課程。來自受尊敬專家的集體貢獻，將單細胞技術的多樣化方面匯集在一本手冊中。這將使生物技術行業的研究人員和從業者在不同疾病的分析、治療、診斷、藥物發現、藥物篩選等方面受益。

除了紙本書籍外，本書還將在線上提供，並將由作者定期更新。

作者簡介

Tuhin Subhra Santra is Assistant Professor in the Department of Engineering Design at the Indian Institute of Technology Madras, India, from July 2016. He was a tenure track "Honorary Visiting Professor" at National Tsing Hua University" Taiwan from 2108 to

2020, and he was a "Visiting Professor" at the University of Cambridge, UK, in 2019. Dr. Santra received his Ph.D. degree in Bio-Nano Electro Mechanical Systems (Bio-NEMS) from National Tsing Hua University (NTHU), Taiwan, in 2013. Dr. Santra was a Postdoctoral

Researcher at the California NanoSystems Institute (CNSI), University of California, Los Angeles (UCLA), USA, from 2015 to 2016. His main research areas are Bio-NEMS, MEMS, single cell technology, single molecule detection, biomedical micro-/nano devices, nanomedicine, etc. Currently, Dr. Santra is serving as a Guest Editor for Cells, Micromachines, MDPI Journals and Frontiers of Bioengineering and

Biotechnology. He served as a Guest Editor for Cells, MDPI, in 2020; International Journal of Molecular Sciences (IJMS) in 2018, 2017, and 2015; Sensors in 2016; Molecules in 2016; and Micromachines in 2020 and 2013, among others. He was conference chair and

committee member of IEEE-NEMS in 2017, 2020 and 2021.

Dr. Santra has received many honors and awards such as "DBT/Wellcome Trust India Alliance Fellowship" in 2018, Honorary Research Fellow from National Tsing Hua University, Taiwan, in 2018, Bharat Bikas Award in 2017, IEEE-NEMS best conference paper award in 2014, a silver medal from Vidyasagar University in 2004, etc. He is Editor of the book entitled Nanomaterials and Their Biomedical Applications by

Springer Nature, Singapore, in 2021; Microfluidics and Bio-NEMS: Devices and Applications by Jenny Stanford Publisher, Singapore, in 2020; and Essential of Single Cell Analysis Springer, Germany, in 2016, among others. He published more than 6 books, 35 SCI journals, 20 book chapters, 15 US/Taiwan/Indian patents, and 20 international conference proceedings in his research field.



Dr. Fan-Gang (kevin) Tseng received his Ph.D. degree in Mechanical Engineering from UCLA, USA, in 1998. He joined Engineering and System Department of National Tsing Hua University in 1999 and advanced to Professor in 2006. He was the Chairman of ESS Department in NTHU (2010-2013), Associate Vice President for Global Affair in NTHU (2013), a Visiting Scholar of Koch Institute of Integrated Cancer Research

in MIT USA (2014-2015), and the Dean of Nuclear Science College in NTHU (2016-2017). He is currently a distinguished professor of ESS Department as well as NEMS I., and the Vice President for R&D at NTHU (2017-present), as well as a Research Fellow with Academia

Sinica Taiwan (2006-present). He was elected an ASME fellow in 2014. His research interests are in the fields of BioNEMS, biosensors, micro-fluidics, tissue chips, and fuel cells. He received 60 patents, wrote 8 book chapters, and published more than 260 SCI

journal papers and 400 conference technical papers.He has received several awards, including Shakelton Scholar, twice National Innovation Award, twice Outstanding in Research Award, and Mr. Wu, Da-Yo Memorial Award from MOST, Taiwan, and more than20 best papers and other awards in various international conferences and competitions. He is among the editorial board of several journals including IJMS, Cells,

Micromachines, and Applied Science, and also the general co-chair for MicroTas 2018 and a board member of CBMS from 2018 to 2022.

作者簡介(中文翻譯)

Tuhin Subhra Santra 自2016年7月起擔任印度馬德拉斯印度理工學院工程設計系的助理教授。他於2018年至2020年期間擔任國立清華大學的「名譽訪問教授」，並於2019年擔任英國劍橋大學的「訪問教授」。Santra博士於2013年在國立清華大學獲得生物奈米電機系統（Bio-NEMS）博士學位。2015年至2016年，他在美國加州大學洛杉磯分校的加州奈米系統研究所（CNSI）擔任博士後研究員。他的主要研究領域包括生物奈米電機系統、微電機系統（MEMS）、單細胞技術、單分子檢測、生醫微/奈米設備、奈米醫學等。目前，Santra博士擔任《Cells》、《Micromachines》、《MDPI Journals》和《Frontiers of Bioengineering and Biotechnology》的客座編輯。他曾於2020年擔任《Cells, MDPI》的客座編輯，2018、2017和2015年擔任《International Journal of Molecular Sciences (IJMS)》的客座編輯，2016年擔任《Sensors》和《Molecules》的客座編輯，以及2020年和2013年擔任《Micromachines》的客座編輯等。他在2017、2020和2021年擔任IEEE-NEMS的會議主席和委員會成員。

Santra博士獲得了許多榮譽和獎項，包括2018年的「DBT/Wellcome Trust India Alliance Fellowship」、2018年國立清華大學的名譽研究員、2017年的Bharat Bikas Award、2014年的IEEE-NEMS最佳會議論文獎、2004年來自Vidyasagar University的銀牌等。他是2021年由Springer Nature出版的《Nanomaterials and Their Biomedical Applications》一書的編輯；2020年由Jenny Stanford Publisher出版的《Microfluidics and Bio-NEMS: Devices and Applications》；以及2016年由Springer出版的《Essential of Single Cell Analysis》等書的編輯。他在其研究領域發表了超過6本書籍、35篇SCI期刊論文、20篇書章、15項美國/台灣/印度專利，以及20篇國際會議論文集。


Dr. Fan-Gang (Kevin) Tseng 於1998年在美國加州大學洛杉磯分校獲得機械工程博士學位。他於1999年加入國立清華大學工程與系統系，並於2006年晉升為教授。他曾擔任國立清華大學ESS系主任（2010-2013）、國立清華大學全球事務副校長（2013）、美國麻省理工學院Koch綜合癌症研究所的訪問學者（2014-2015），以及國立清華大學核科學學院院長（2016-2017）。目前，他是ESS系及NEMS I的特聘教授，並擔任國立清華大學的研發副校長（2017年至今），同時也是中央研究院的研究員（2006年至今）。他於2014年被選為ASME會士。他的研究興趣包括生物奈米電機系統、生物感測器、微流體技術、組織晶片和燃料電池。他擁有60項專利，撰寫了8篇書章，並發表了超過260篇SCI期刊論文和400篇會議技術論文。他獲得了多項獎項，包括Shakelton Scholar、兩次國家創新獎、兩次研究傑出獎，以及來自台灣科技部的吳大猷紀念獎，並在各種國際會議和競賽中獲得20多項最佳論文及其他獎項。他是多本期刊的編輯委員會成員，包括IJMS、Cells、Micromachines和Applied Science，並擔任2018年MicroTas的共同主席，以及2018至2022年CBMS的董事會成員。

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