Middle Molecular Strategy: Flow Synthesis to Functional Molecules
暫譯: 中分子策略：從流動合成到功能分子

Name: Middle Molecular Strategy: Flow Synthesis to Functional Molecules
Price: 6679 TWD
Availability: OnlineOnly
Author: Fukase, Koichi, Doi, Takayuki
ISBN: 9811624577

Fukase, Koichi, Doi, Takayuki

出版商: Springer
出版日期: 2021-07-14
售價: $7,030
貴賓價: 9.5 折 $6,679
語言: 英文
頁數: 357
裝訂: Hardcover - also called cloth, retail trade, or trade
ISBN: 9811624577
ISBN-13: 9789811624575
相關分類: 化學 Chemistry、生物資訊 Bioinformatics

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商品描述

Part I: Development of bio-functional middle molecules.- 1. Introduction.- 2. Total Synthesis, Biological Evaluation and 3D Structural Analysis of Cyclodepsipeptide Natural Products.- 3. Development of the Middle-size Molecules for Alkylation to Higher-Order Structures of Nucleic Acids.- 4. In Situ Synthesis of Glycoconjugates on Cell Surface: Selective Cell Imaging Using Low-Affinity Glycan Ligands.- 5. Assembled mid-sized agents that control intracellular protein-protein interactions.- 6. Macrocyclic mid-sized peptides with new chemical modalities.- Part II: Achievement of highly efficient synthesis of bioactive middle molecules.- 7. Enantioselective Total Synthesis of Cotylenin.- 8. Flow Chemistry for the Construction of Polycyclic Skeleton.- 9. Electrochemical Synthesis of Oligosaccharides as Middle-sized Molecules.- 10. Efficient Synthesis of Biologically Active Peptides based on Micro-flow Amide Bond Formation.- 11. Design and Concise De Novo Synthesis of Artemisinin Analogs.

商品描述(中文翻譯)

第一部分：生物功能中等分子的開發。- 1. 介紹。- 2. 環狀去氨酸天然產物的總合成、生物評估及三維結構分析。- 3. 中等大小分子的開發，用於核酸的烷基化以形成高階結構。- 4. 在細胞表面原位合成糖偶聯物：使用低親和力糖苷配體的選擇性細胞成像。- 5. 組裝的中等大小試劑，控制細胞內蛋白質-蛋白質相互作用。- 6. 具有新化學模式的宏環中等大小肽。- 第二部分：高效合成生物活性中等分子的成就。- 7. Cotylenin 的對映選擇性總合成。- 8. 用於構建多環骨架的流動化學。- 9. 作為中等大小分子的寡糖的電化學合成。- 10. 基於微流動酰胺鍵形成的生物活性肽的高效合成。- 11. 青蒿素類似物的設計與簡明的去新合成。

作者簡介

Koichi Fukase graduated from the Department of Chemistry, Osaka University, in 1982 and received his Ph.D. from Osaka University (under Prof. Tetsuo Shiba) in 1987. After spending 1 year as a JSPS Postdoctoral Fellow (under Prof. Shiba), he was appointed as Assistant Professor (1988-1996) at the Department of Chemistry, School of Science, Osaka University (under Prof. Shoichi Kusumoto). In 1994, he joined Prof. W. Clark Still's group at Columbia University as a Ministry of Education Research Fellow. After returning to Osaka in 1995, he was promoted to Lecturer (1996) and Associate Professor (1998) and became Full Professor at the Department of Chemistry, Graduate School of Science, Osaka University, in 2004. He received the Chemical Society of Japan Award for Creative Work in 2011. His research interests include carbohydrate chemistry and glycobiology, synthetic organic chemistry, bio-imaging, and innate immunity.

Takayuki Doi received his Ph.D. from Tokyo Tech in 1991 (under Prof. Takashi Takahashi). After a postdoctoral scientist position under Prof. Gilbert Stork at Columbia University, he joined Tokyo Tech as Assistant Professor in 1993 and became Associate Professor in 2001. He was promoted to Full Professor at the Graduate School of Pharmaceutical Sciences, Tohoku University, in 2008 and joined the Graduate School of Life Sciences in 2018. He received the Progress Award in Synthetic Organic Chemistry, Japan in 2000, and the Pharmaceutical Society of Japan Award for Divisional Scientific Promotions in 2013.

作者簡介(中文翻譯)

福家浩一於1982年畢業於大阪大學化學系，並於1987年在大阪大學（在柴田哲夫教授指導下）獲得博士學位。在擔任日本學術振興會（JSPS）博士後研究員（在柴田教授指導下）一年後，他於1988年至1996年擔任大阪大學科學學院化學系的助理教授（在楠本昌一教授指導下）。1994年，他以教育部研究員的身份加入哥倫比亞大學的W. Clark Still教授團隊。1995年回到大阪後，他於1996年晉升為講師，1998年晉升為副教授，並於2004年成為大阪大學科學研究所化學系的正教授。他於2011年獲得日本化學會創新工作獎。其研究興趣包括碳水化合物化學和糖生物學、合成有機化學、生物成像和先天免疫。

土井隆之於1991年在東京科技大學獲得博士學位（在高橋隆教授指導下）。在哥倫比亞大學的吉爾伯特·斯托克教授指導下擔任博士後科學家職位後，他於1993年加入東京科技大學擔任助理教授，並於2001年成為副教授。他於2008年晉升為東北大學藥學研究所的正教授，並於2018年加入生命科學研究所。他於2000年獲得日本合成有機化學進步獎，並於2013年獲得日本藥學會分部科學推廣獎。