Gene Regulation and Metabolism: Postgenomic Computational Approaches
Julio Collado-Vides , Ralf Hofestdt
- 出版商: MIT
- 出版日期: 2004-08-20
- 售價: $1,050
- 貴賓價: 9.8 折 $1,029
- 語言: 英文
- 頁數: 320
- 裝訂: Paperback
- ISBN: 0262532689
- ISBN-13: 9780262532686
As exciting as the new field of genomics is, it has not yet produced a basic conceptual change in biology. The fundamental problems remain: the origin of life, cell organization, the pathways of differentiation, aging, and the molecular and cellular capabilities of the brain. What has occurred is an explosion of molecular information obtained by genomic sequences, which will soon be followed by exhaustive catalogs of protein interactions and protein function. This wealth of information can be analyzed and manipulated only with the help of computers. The rapidly expanding role of computers in biology may usher in a profound conceptual change in how we study living systems in the laboratory.
This book focuses on current computational approaches to understanding the complex networks of metabolic and gene regulatory capabilities of the cell. The contributors look well beyond the state of the art in computational biology to anticipate what biological research will be like in a post-genomic world.
Julio Collado-Vides is Professor and Head of the Laboratory of Computational Biology at the Universidad Nacional Autónoma de México, Cuernavaca. He is coeditor of Integrative Approaches to Molecular Biology (MIT Press, 1996).
Ralf Hofestädt is Professor of Bioinformatics and Medical Informatics at the University of Bielefeld.
Table of Contents:
|1||Are the Eyes Homologous?
Jeremy C. Ahouse
|I||Information and Knowledge Representation||17|
|2||Automation of Protein Sequence Characterization and Its
Application in Whole Proteome Analysis
Rolf Apweiler, Margaret Biswas, Wolfgang Fleischmann, Evgenia V. Kriventseva and Nicola Mulder
|3||Information Fusion and Metabolic Network
Andreas Freier, Ralf Hofestädt, Matthias Lange and Uwe Scholz
|II||Gene Regulation: From Sequence to Networks||85|
|4||Specificity of Protein-DNA Interactions
Gary D. Stormo
|5||Genomics of Gene Regulation: The View from
Julio Collado-Vides, Gabriel Moreno-Hagelsieb, Ernesto Pérez-Rueda, Heladia Salgado, Araceli M. Huerta, Rosa Maria Gutiérrez, David A. Rosenblueth, Andrés Christen, Esperanza Benitez-Bellon, Arturo Medrano-Soto, Socorro Gama-Castro, Alberto Santos-Zavaleta, César Bonavides-Martinez, Edgar Diaz-Peredo, Fabiola Sanchez-Solano and Dulce Maria Millan
|6||Discovery of DNA Regulatory Motifs
Abigail Manson McGuire and George M. Church
|7||Gene Networks Description and Modeling in the GeneNet
Nikolay A. Kolchanov, Elena A. Ananko, Vitali A. Likhoshvai, Olga A. Podkolodnaya, Elena V. Ignatieva, Alexander V. Ratushny and Yuri G. Matushkin
|8||Regulation of Cellular States in Mammalian Cells from a
|9||Predicting Protein Function and Networks on a
Edward M. Marcotte
Steffen Schmidt and Thomas Dandekar
|11||Toward Computer Simulation of the Whole