Multiple Testing Procedures with Applications to Genomics (Springer Series in Statistics)

Sandrine Dudoit, Mark J. van der Laan

  • 出版商: Springer
  • 出版日期: 2007-12-19
  • 售價: $9,507
  • 貴賓價: 9.5$9,032
  • 語言: 英文
  • 頁數: 590
  • 裝訂: Hardcover
  • ISBN: 0387493166
  • ISBN-13: 9780387493169
  • 相關分類: 機率統計學

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商品描述

This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.