Microarray Bioinformatics

This book is a comprehensive guide to all of the mathematics, statistics and computing you will need to successfully operate DNA microarray experiments. It is written for researchers, clinicians, laboratory heads and managers, from both biology and bioinformatics backgrounds, who work with, or who intend to work with microarrays. The book covers all aspects of microarray bioinformatics, giving you the tools to design arrays and experiments, to analyze your data, and to share your results with your organisation or with the international community. There are chapters covering sequence databases, oligonucleotide design, experimental design, image processing, normalisation, identifying differentially expressed genes, clustering, classification and data standards. The book is based on the highly successful Microarray Bioinformatics course at Oxford University, and therefore is ideally suited for teaching the subject at postgraduate or professional level.

本書是一本全面指南，涵蓋了您在操作DNA微陣列實驗中所需的所有數學、統計和計算知識。它針對生物學和生物信息學背景的研究人員、臨床醫生、實驗室主管和管理人員撰寫，他們與微陣列一起工作或打算開展微陣列工作。本書涵蓋了微陣列生物信息學的所有方面，為您提供設計陣列和實驗、分析數據以及與組織或國際社區分享結果的工具。書中包含了關於序列數據庫、寡核苷酸設計、實驗設計、圖像處理、歸一化、鑒定差異表達基因、聚類、分類和數據標準的章節。本書基於牛津大學非常成功的微陣列生物信息學課程，因此非常適合在研究生或專業水平上教授這一主題。