Protein Interaction Networks: Computational Analysis (Hardcover)

Aidong Zhang

  • 出版商: Cambridge University Press
  • 出版日期: 2009-04-06
  • 定價: USD $98.00
  • 售價: $3,612
  • 貴賓價: 9.5$3,431
  • 語言: 英文
  • 頁數: 292
  • 裝訂: Hardcover
  • ISBN: 0521888956
  • ISBN-13: 9780521888950

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商品描述

The analysis of protein-protein interactions is fundamental to the understanding of cellular organization, processes, and functions. Recent large-scale investigations of protein-protein interactions using such techniques as two-hybrid systems, mass spectrometry, and protein microarrays have enriched the available protein interaction data and facilitated the construction of integrated protein-protein interaction networks. The resulting large volume of protein-protein interaction data has posed a challenge to experimental investigation. This book provides a comprehensive understanding of the computational methods available for the analysis of protein-protein interaction networks. It offers an in-depth survey of a range of approaches, including statistical, topological, data-mining, and ontology-based methods. The author discusses the fundamental principles underlying each of these approaches and their respective benefits and drawbacks, and she offers suggestions for future research.