Therapeutic Potential of Natural Products in Neurodegenerative Disorders
暫譯: 天然產品在神經退行性疾病中的治療潛力

本書回顧了天然產品在神經退行性疾病治療和管理中的潛力。導言章節提供了對神經退行性疾病的基本見解。隨後，本書涵蓋了多酚及其他藥物在肌萎縮側索硬化症（amyotrophic lateral sclerosis）中的治療潛力，天然成分在弗里德里希共濟失調（Friedreich's ataxia）中的應用，以及天然成分在亨廷頓病（Huntington's disease）治療中的聯合效果。本書還探討了路易體病（Lewy body disease）的傳統治療方案，並檢視了天然和合成藥物的協同效果。此外，各章節討論了天然提取物在脊髓性肌萎縮症（spinal muscular atrophy）管理中的應用，同時檢視了更廣泛的合成管理方法。本書的第二部分探討了用於管理神經退行性疾病的奈米傳遞系統。它討論了協同治療方法，隨後分析了電子紡絲（electron spinning）和電子噴霧（electron spraying）等先進技術及其在神經退行性疾病中的應用。本書還回顧了類黃酮（flavonoids）在管理神經退行性疾病中的治療潛力。最後，本書還檢視了在神經退行性疾病治療中使用天然療法的倫理框架。本書旨在為神經科學家及神經學、藥理學和奈米技術領域的研究人員提供參考。

Ghulam Md Ashraf is an accomplished biochemist and molecular neuroscientist with 15 years of experience in research, teaching, and innovation across the biological, health, and medical sciences. He holds a dual degree--Ph.D. in Biochemistry (Aligarh Muslim University, India) and PGDBA in Operations Management (Symbiosis Center for Distance Learning, India)--and completed the prestigious Instructional Skills Workshop (ISW) in collaboration with the University of British Columbia, Canada, enhancing his pedagogical expertise. His research focuses on molecular mechanisms and therapeutic strategies for neurodegenerative disorders, including multiple sclerosis and Alzheimer's disease. His lab investigates serotonin receptor signaling, develops selective modulators to counteract pathological protein aggregation, and advances next-generation Multiple Sclerosis therapies, including engineered interferons and nanomedicine-based neuroprotective delivery. Dr. Ashraf is recognized among the Top 2% of Scientists Worldwide since 2021 (Stanford-PLOS-Elsevier), the leading Biochemistry Scientist in the UAE (AD Scientific Index), and a World Expert in Neurodegenerative Diseases (Expertscape). He is listed in Marquis Who's Who in the World (since 2020), has received the Publons/Web of Science Top Reviewer Awards in Cross-Field and Biology & Biochemistry (2019), holds 4 international patents, and has authored nearly 450 publications with 20,000 citations (H-index 70). Dr. Ashraf has held leadership roles in research administration and laboratory management and has extensive editorial experience with journals including Journal of Advanced Research, Scientific Reports, and Plos One. He is a Fellow of the Royal Society of Medicine (FRSM), a Member of the Royal Society of Biology (MRSB), and an active member of international scientific societies such as the Canadian Academy of Neuroscience and the American Society for Biochemistry and Molecular Biology. Dr. Ashraf's work exemplifies the integration of advanced research, innovation, and global collaboration to advance biomedical science and improve human health.

Md. Habibur Rahman is Registered Pharmacist in Bangladesh and a member of the Novel Global Community Education Foundation (Australia). He earned his Ph.D. in Medical Science from Yonsei University, South Korea, and has contributed his expertise to several leading pharmaceutical organizations. His research is primarily focused on neuroscience, particularly the molecular mechanisms underlying clinical dementia, with emphasis on biomarker discovery and targeted diagnostic strategies. In addition to his neuroscience work, Dr. Rahman is an expert in molecular biology, with extensive experience in gene expression analysis, oxidative stress pathways, and neuroinflammation. He has been recognized among the top 2% of scientists worldwide (Stanford University, citation-based global ranking) for his impactful contributions. Dr. Rahman is also an active scientific communicator and public speaker, frequently presenting at international conferences and academic forums. He serves as a peer reviewer for several high-impact journals and is involved in multiple ongoing research collaborations in neuroscience and molecular medicine.

Karri V. V. S. Narayana Reddy is Associate Professor in the Department of Pharmaceutics at JSS College of Pharmacy, Ooty, India. A proud alumnus of the same institution, he completed his B.Pharm, M.Pharm, and Ph.D. in Pharmaceutics from JSS College of Pharmacy, Ooty. Recognized among the Top 2% of Scientists in the World by Stanford University for three consecutive years (2022, 2023, and 2024), Dr. Reddy has made significant contributions to pharmaceutical sciences. His expertise spans nanodrug delivery, diabetic wound healing, and biomaterials, with a particular focus on natural products and innovative formulations. He has published over 100 peer-reviewed research articles, authored several book chapters, and holds multiple patents related to advanced drug delivery systems. Dr. Reddy also serves as a research coordinator, an active Ph.D. guide, and is on the editorial board and review panels of reputed international journals.

Chenmala Karthika is Postdoctoral Fellow at the National Institute of Health in the USA. She completed her Ph.D. at JSS College of Pharmacy, Ooty, and has published more than 35 national and international research articles in journals of high repute. Over the past five years, her research has focused on cancer and its therapeutic approaches, with an additional interest in aging, COVID-19, and neurodegenerative disorders.

Ali T. Zari is Assistant Professor in the Department of Biological Sciences at the Faculty of Sciences, King Abdulaziz University in Jeddah, Saudi Arabia. He obtained his Bachelor of Science in Biology in 2007 from King Abdulaziz University and completed his Master of Science in Biology in 2014 at Laurentian University in Canada. He earned his Ph.D. in biomolecular sciences from Laurentian University in Canada in 2019. Dr. Zari's research interests encompass the examination of the effects of medicinal plants and their bioactive components on various cancer cells and other diseases using biomolecular techniques in vitro and in vivo to investigate their potential effectiveness as pharmaceutical sources. Additionally, he investigates the potential benefits and risks of using nanomaterials for therapeutic purposes. Dr. Zari is also involved in in silico prediction of cancer inhibitors and protein modeling for antitumor activity. He has diverse teaching experiences at the graduate and postgraduate levels in the fields of general biology, molecular biology, cell biology, natural products, and animal physiology at King Abdulaziz University.

Gowthamarajan Kuppusamy is Professor and Head, Department of Pharmaceutics (DST-FIST Sponsored), JSS College of Pharmacy, Ooty (JSS Academy of Higher Education & Research, Mysuru). He holds M.Pharm (1996) and Ph.D. (2007) degrees from the Tamil Nadu Dr. MGR Medical University, Chennai. With over two decades of academic and research experience, he has developed industry relevant academic programs and led collaborative projects in intranasal and nanotechnology-based drug delivery. His current focus is on optimized and personalized drug delivery systems. He has guided over 50 PG and 18 Ph.D. scholars. He has executed several government-funded projects in areas such as Alzheimer's disease, colorectal cancer, cardiovascular diseases, and space medicine, receiving grants from DST-SERB, AICTE, ICMR, DBT, and SPARC. He has played a significant role in technology transfers and serves as a consultant for multiple pharmaceutical industries. Dr. Gowthamarajan has been consistently listed among the top 2% scientists globally by Stanford University and Elsevier for the past three consecutive years (2022-2024). He has over 150 peer-reviewed publications and 23 patents and is a member of national academic bodies, editorial boards, and regulatory committees.

Ghulam Md Ashraf 是一位成就卓越的生物化學家和分子神經科學家，擁有 15 年的研究、教學和創新經驗，涵蓋生物、健康和醫學科學。他擁有雙學位——生物化學博士（印度阿里格爾穆斯林大學）和運營管理研究生文憑（印度辛比奧西斯遠程學習中心），並完成了與加拿大不列顛哥倫比亞大學合作的著名教學技能研討會（ISW），提升了他的教學專業知識。他的研究重點是神經退行性疾病的分子機制和治療策略，包括多發性硬化症和阿茲海默症。他的實驗室研究血清素受體信號傳導，開發選擇性調節劑以對抗病理性蛋白聚集，並推進下一代多發性硬化症療法，包括工程干擾素和基於納米醫學的神經保護傳遞。自 2021 年以來，Dr. Ashraf 被認定為全球前 2% 科學家（斯坦福-PLOS-Elsevier），是阿聯酋的領先生物化學科學家（AD Scientific Index），以及神經退行性疾病的世界專家（Expertscape）。他自 2020 年以來被列入《馬奎斯世界名人錄》，並在跨領域及生物學與生物化學領域獲得 Publons/Web of Science 的最佳審稿人獎（2019），擁有 4 項國際專利，並發表近 450 篇出版物，引用次數達 20,000 次（H-index 70）。Dr. Ashraf 在研究管理和實驗室管理方面擔任過領導職位，並在《Journal of Advanced Research》、《Scientific Reports》和《Plos One》等期刊擁有豐富的編輯經驗。他是英國皇家醫學會的院士（FRSM）、英國皇家生物學會的成員（MRSB），並積極參與加拿大神經科學學會和美國生物化學與分子生物學會等國際科學社團。Dr. Ashraf 的工作體現了先進研究、創新和全球合作的整合，以推進生物醫學科學並改善人類健康。

Md. Habibur Rahman 是孟加拉國的註冊藥劑師，也是新穎全球社區教育基金會（澳大利亞）的成員。他在韓國延世大學獲得醫學科學博士學位，並將他的專業知識貢獻給幾家領先的製藥機構。他的研究主要集中在神經科學，特別是臨床癡呆的分子機制，強調生物標記的發現和針對性的診斷策略。除了神經科學的工作外，Dr. Rahman 還是分子生物學的專家，擁有基因表達分析、氧化壓力途徑和神經炎症的豐富經驗。他因其影響深遠的貢獻而被認定為全球前 2% 的科學家（斯坦福大學，基於引用的全球排名）。Dr. Rahman 也是一位活躍的科學傳播者和公共演講者，經常在國際會議和學術論壇上發表演講。他擔任多本高影響力期刊的同行評審，並參與多個神經科學和分子醫學的持續研究合作。

Karri V. V. S. Narayana Reddy 是印度烏堤 JSS 藥學院藥劑學系的副教授。他是該機構的自豪校友，完成了 B.Pharm、M.Pharm 和藥劑學博士學位。Dr. Reddy 連續三年（2022、2023 和 2024）被斯坦福大學認定為全球前 2% 的科學家，對藥學科學做出了重要貢獻。他的專業涵蓋納米藥物傳遞、糖尿病傷口癒合和生物材料，特別專注於天然產品和創新配方。他發表了超過 100 篇同行評審的研究文章，撰寫了幾個書籍章節，並擁有多項與先進藥物傳遞系統相關的專利。Dr. Reddy 還擔任研究協調員，積極指導博士生，並在多本知名國際期刊的編輯委員會和審稿小組中任職。

Chenmala Karthika 是美國國立衛生研究院的博士後研究員。她在烏堤的 JSS 藥學院完成了博士學位，並在多本高聲望的期刊上發表了超過 35 篇國內外研究文章。在過去五年中，她的研究專注於癌症及其治療方法，並對衰老、COVID-19 和神經退行性疾病有額外的興趣。

Ali T. Zari 是沙烏地阿拉伯吉達阿卜杜勒阿齊茲國王大學生物科學系的助理教授。他於 2007 年在阿卜杜勒阿齊茲國王大學獲得生物學學士學位，並於 2014 年在加拿大勞倫森大學獲得生物學碩士學位。他於 2019 年在勞倫森大學獲得生物分子科學博士學位。Dr. Zari 的研究興趣包括使用生物分子技術體外和體內檢查藥用植物及其生物活性成分對各種癌細胞和其他疾病的影響，以研究其作為藥物來源的潛在有效性。此外，他還研究使用納米材料進行治療的潛在好處和風險。Dr. Zari 也參與癌症抑制劑的計算預測和抗腫瘤活性的蛋白質建模。他在阿卜杜勒阿齊茲國王大學的研究生和研究所層級擁有多樣的教學經驗，涵蓋一般生物學、分子生物學、細胞生物學、天然產品和動物生理學等領域。

Gowthamarajan Kuppusamy 是印度烏堤 JSS 藥學院（JSS 高等教育與研究學院，邁索爾）藥劑學系的教授和主任。他擁有來自印度金奈的泰米爾納德邦醫科大學的 M.Pharm（1996）和博士學位（2007）。擁有超過二十年的學術和研究經驗，他開發了與行業相關的學術課程，並主導了基於鼻用和納米技術的藥物傳遞的合作項目。他目前的重點是優化和個性化的藥物傳遞系統。他已指導超過 50 名碩士生和 18 名博士生。他執行了多個政府資助的項目，涵蓋阿茲海默症、結腸癌、心血管疾病和太空醫學等領域，並獲得了來自 DST-SERB、AICTE、ICMR、DBT 和 SPARC 的資助。他在技術轉移方面發揮了重要作用，並擔任多家製藥公司的顧問。Dr. Gowthamarajan 在過去三年（2022-2024）中持續被斯坦福大學和 Elsevier 列為全球前 2% 的科學家。他擁有超過 150 篇同行評審的出版物和 23 項專利，並是國家學術機構、編輯委員會和監管委員會的成員。