Diffuse Optical Tomography: Principles and Applications (Hardcover)

Written by an authority involved in the field since its nascent stages, Diffuse Optical Tomography: Principles and Applications is a long-awaited profile of a revolutionary imaging method. Diffuse Optical Tomography (DOT) provides spatial distributions of intrinsic tissue optical properties or molecular contrast agents through model-based reconstruction algorithms using NIR measurements along or near the boundary of tissue.

Despite the practical value of DOT, many engineers from electrical or applied mathematics backgrounds do not have a sufficient understanding of its vast clinical applications and portability value, or its uncommon advantages as a tool for obtaining functional, cellular, and molecular parameters. A collection of the author’s research and experience, this book fuses historical perspective and experiential anecdotes with fundamental principles and vital technical information needed to successfully apply this technology—particularly in medical imaging.

This reference finally outlines how to use DOT to create experimental image systems and adapt the results of laboratory studies for use in clinical applications including:

• Early-stage detection of breast tumors and prostate cancer
• "Real-time" functional brain imaging
• Joint imaging to treat progressive diseases such as arthritis
• Monitoring of tumor response
• New contrast mechanisms and multimodality methods

This book covers almost every aspect of DOT—including reconstruction algorithms based on nonlinear iterative Newton methods, instrumentation and calibration methods in both continuous-wave and frequency domains, and important issues of imaging contrast and spatial resolution. It also addresses phantom experiments and the development of various image-enhancing schemes, and it describes reconstruction methods based on contrast agents and fluorescence DOT.

Offering a concise description of the particular problems involved in optical tomography, this reference illustrates DOT’s fundamental foundations and the principle of image reconstruction. It thoroughly explores computational methods, forward mathematical models, and inverse strategies, clearly illustrating solutions to key equations.

由一位從事該領域的權威人士撰寫，《散射光學斷層掃描：原理與應用》是對一種革命性成像方法的期待已久的介紹。散射光學斷層掃描（DOT）通過基於模型的重建算法，使用近紅外測量沿著或靠近組織邊界的方式，提供內在組織光學特性或分子對比劑的空間分布。

儘管DOT具有實用價值，但許多電氣或應用數學背景的工程師對其廣泛的臨床應用和可移植性價值，以及作為獲取功能、細胞和分子參數的工具的非凡優勢缺乏足夠的理解。這本書是作者的研究和經驗的結集，融合了歷史觀點和經驗故事，以及成功應用這項技術所需的基本原理和重要技術信息，特別是在醫學成像領域。

這本參考書最終概述了如何使用DOT創建實驗性影像系統，並將實驗室研究的結果應用於臨床應用，包括：

- 早期檢測乳腺腫瘤和前列腺癌
- "實時"功能性腦成像
- 關節成像以治療像關節炎等進行性疾病
- 腫瘤反應監測
- 新的對比機制和多模態方法

本書涵蓋了幾乎DOT的所有方面，包括基於非線性迭代牛頓方法的重建算法、連續波和頻率域中的儀器和校準方法，以及成像對比和空間分辨率的重要問題。它還涉及幻影實驗和各種增強影像方案的開發，並描述了基於對比劑和螢光DOT的重建方法。

本書提供了對光學斷層掃描所涉及的特定問題的簡明描述，說明了DOT的基本基礎和圖像重建原理。它徹底探討了計算方法、正向數學模型和反向策略，清楚地說明了關鍵方程的解決方案。