Paratransgenesis and Vector-Borne Disease Control
暫譯: 旁轉基因技術與媒介傳播疾病控制

本書概述了旁轉基因技術（paratransgenesis），這是一種控制傳染病的創新方法。在旁轉基因干預中，節肢動物媒介的細菌共生體被轉化為表達針對目標病原體的分子。該媒介通過誘餌配方接種轉化後的細菌。細菌在媒介中繁殖並輸出抗病原體分子，從而中斷疾病傳播。旁轉基因技術提供了一種可持續、環保的替代方案，取代了使用農藥進行媒介根除的方法，後者受到環境毒性、成本和媒介抗性發展的限制。

Dr. Ravi Durvasula is Chief of Infectious Diseases, Director of The Center for Global Health and Professor of Medicine at University of New Mexico School of Medicine. For nearly 15 years, Dr. Durvasula has been developing paratransgenic methods for control of important arthropod-borne infectious diseases. Dr. Durvasula's lab has developed novel control systems using engineered symbiotic and commensal bacteria of arthropods. His work on triatomine bug vectors of Chagas disease has been funded through NIH RO1 grants and he is currently establishing collaborative ties for validation of the approach in Argentina. Through a series of grants from the US Department of Agriculture, Dr. Durvasula's group has developed paratransgenic strategies to reduce transmission of plant pathogens via the pest arthropod, Glassy Winged Sharpshooter. In collaboration with investigators in India, Tunisia and Iran, the Durvasula group is developing paratransgenic approaches to control of transmission of leishmania parasites by sand flies.

Through the Center for Global Health at University of New Mexico School of Medicine, Dr. Durvasula maintains active collaborations across the globe, to further both research programs and clinical exchange with the United States. The author of over 100 manuscripts, book chapters and conference abstracts, Dr. Durvasula is widely recognized for his contributions to infectious diseases and, in particular, vector-borne diseases. In 2009, he was elected to The American Society for Clinical Investigation and he serves on numerous Study Sections of The National Institutes of Health, Department of Defense and The Burroughs Wellcome Foundation.

Scott Matthews has worked in the laboratory of Ravi V. Durvasula since 2002. His work in paratransgenesis is extensive and includes development of the first risk assessment framework for paratransgenesis. He received a Master of Public Health degree from Yale University and is scheduled to graduate as an M. D. from the University of New Mexico School of Medicine in May of 2015.

拉維·杜瓦蘇拉博士是新墨西哥大學醫學院傳染病科主任、全球健康中心主任及醫學教授。近15年來，杜瓦蘇拉博士一直在開發控制重要節肢動物傳播的傳染病的旁轉基因方法。杜瓦蘇拉博士的實驗室已經開發出使用工程化的共生和共棲細菌的創新控制系統。他在查加斯病的三角蟲媒介方面的研究得到了NIH RO1獎助金的資助，目前他正在阿根廷建立合作關係以驗證這一方法。通過美國農業部的一系列獎助金，杜瓦蘇拉博士的團隊已經開發出旁轉基因策略，以減少通過害蟲玻璃翅尖蝨傳播植物病原體的風險。杜瓦蘇拉團隊與印度、突尼西亞和伊朗的研究人員合作，正在開發旁轉基因方法以控制沙蠅傳播利什曼原蟲的傳播。

通過新墨西哥大學醫學院的全球健康中心，杜瓦蘇拉博士在全球範圍內保持活躍的合作，以促進研究計劃和與美國的臨床交流。杜瓦蘇拉博士是超過100篇手稿、書籍章節和會議摘要的作者，因其對傳染病，特別是媒介傳播疾病的貢獻而廣受認可。2009年，他當選為美國臨床研究學會會員，並在多個國家衛生研究院、國防部和巴羅克威爾康基金會的研究小組中任職。

斯科特·馬修斯自2002年以來一直在拉維·杜瓦蘇拉的實驗室工作。他在旁轉基因方面的工作非常廣泛，包括開發旁轉基因的第一個風險評估框架。他獲得了耶魯大學的公共衛生碩士學位，並計劃於2015年5月從新墨西哥大學醫學院畢業，獲得醫學博士學位。