Intercellular and Interorganellar Transfer and Communication in Biology and Medicine
暫譯: 生物學與醫學中的細胞間及細胞器間轉移與通訊

Kloc, Malgorzata, Kubiak, Jacek Z., Halasa, Marta

Intercellular and Interorganellar Transfer and Communication in Biology and Medicine
  • 出版商: Springer
  • 出版日期: 2024-09-07
  • 售價: $8,220
  • 貴賓價: 9.5 折 $7,809
  • 語言: 英文
  • 頁數: 579
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 3031620356
  • ISBN-13: 9783031620355
  • 相關分類: GAN 生成對抗網絡

    • 海外代購書籍(需單獨結帳)

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商品描述

This volume covers recent developments on the role, composition, and functional significance of intercellular and interorganellar transfer. It highlights the involvement of intercellular and interorganellar transfer in cell and developmental biology, differentiation, pathogen dissemination, shaping the genetic makeup of organisms, and the development of various diseases.

Animals and plants evolved different communication mechanisms and transfer of molecules and organelles between cells and between organelles within the individual cells. Tunneling nanotubes (TNTs) in animals, discovered as recently as 2004, and their functional equivalent in plants, plasmodesmata, discovered over 100 years ago, are the membranous bridges that mediate the transfer of organelles, membrane patches, vesicles, DNA/RNA, and different molecules between cells. In addition, there are other means of transfer and communication between the cells, such as cytonemes, airinames, extracellular vesicles (exosomes), and others. Variations in cytoskeletal composition, morphology, modality, and connected cells suggest that these structures play a role in development, establishment of cell fate, progenitor cell differentiation, cell reprogramming, ferroptosis, generation of cancer stem cells, and various diseases. The exchange of intact membrane patches (trogocytosis) between cells of the immune system may modify the immune response. Additionally, the transfer of genetic information between nucleus and organelles and cells of different species can shape the species and evolutionary outcome. Viral and bacterial pathogens can hijack the inter-cellular transfer routes to spread more efficiently. Cell-to-cell transfer of animal and plant pathogens can also occur by the virological synapse (VS). These specialized pathogen-induced structures share similarities and differences with neurological and immunological synapses.

商品描述(中文翻譯)

本卷涵蓋了細胞間及細胞器間轉移的角色、組成及功能意義的最新發展。它強調了細胞間及細胞器間轉移在細胞與發展生物學、分化、病原體擴散、塑造生物的遺傳組成以及各種疾病發展中的參與。

動物和植物演化出不同的溝通機制以及分子和細胞器在細胞之間及個別細胞內部的轉移。隧道納米管（TNTs）在動物中於2004年被發現，而其在植物中的功能等價物——質體連接（plasmodesmata）則在100多年前被發現，這些都是介導細胞之間轉移細胞器、膜片段、囊泡、DNA/RNA及不同分子的膜橋。此外，細胞之間還有其他轉移和溝通的方式，例如細胞突（cytonemes）、氣泡突（airinames）、細胞外囊泡（外泌體，exosomes）等。細胞骨架組成、形態、模式及連接細胞的變化表明這些結構在發展、細胞命運的確立、祖細胞分化、細胞重編程、鐵死亡（ferroptosis）、癌幹細胞的生成及各種疾病中扮演著角色。免疫系統細胞之間的完整膜片段交換（trogocytosis）可能會改變免疫反應。此外，不同物種之間的細胞核與細胞器及細胞的遺傳信息轉移可以塑造物種及其進化結果。病毒和細菌病原體可以劫持細胞間轉移路徑以更有效地擴散。動植物病原體之間的細胞對細胞轉移也可以通過病毒突觸（virological synapse，VS）發生。這些專門的病原體誘導結構在神經和免疫突觸中有相似之處和不同之處。

作者簡介

Dr. Malgorzata Kloc: Prior to completing her postdoctoral training in Canada, Dr. Kloc was a tenured Associate Professor in the Department of Zoology at the University of Warsaw, Poland. She also served as a Research Associate in the Department of Biology at Carleton University in Ottawa, Canada. While completing her postdoctoral training, Dr. Kloc earned the AHFMR Research Award from the University of Calgary and the MRC Biotechnology Training Award from Dalhousie University. She joined the University of Texas M.D. Anderson Cancer Center as a Research Scientist in the Department of Molecular Genetics in 1987, and became an Associate Professor in the Department of Biochemistry and Molecular Biology there in 2006. Dr. Kloc joined the Houston Methodist Research Institute in 2008. Currently, Dr. Kloc is the Weill Cornell Professor of Cell and Molecular Biology at The Houston Methodist Hospital and the Adjunct Professor at Department of Genetics, University ofTexas, M D Anderson Cancer Center.

Dr. Jacek Z. Kubiak is the Research Director (Professor) at the French National Research Institute CNRS in Rennes, France. His research is devoted to molecular mechanisms of early embryo development, cell cycle regulation, stem cells, cancer cells and the role of macrophages in the innate immune response. He is the author of over 180 highly cited scientific articles and the editor or co-editor of 10 books. He has graduated from the Warsaw University, Poland and worked at the University of Wisconsin-Madison, USA, Marine Biological Laboratory in Woods Hole, USA and in Jacques Monod Institute in Paris, France. He collaborates with research institute WIM-PIB in Warsaw, Poland combining stem cells, wound healing and cancer research with the prospective in medical applications. Since the COVID-19 outbreak, he co-ordinates an international research group focused on SARS-CoV-2 infection in paediatric patients and he follows up this research field.

Marta Halasa earned her PhD in medical and health science from the Medical University of Lublin, Poland, in 2022. Her research during her doctoral studies focused on epigenetic modifiers, particularly histone deacetylases, and their impact on cancer progression and metastasis. During her PhD, she completed a long-term internship at the University of Turku, Finland, where she gained expertise in 3D cell techniques. She also undertook an internal internship at the Military Institute of Medicine in Warsaw, Poland, where she investigated cell-gene therapy in Alzheimer's disease. After completing her PhD, she obtained a postdoctoral fellow position at the Houston Methodist Research Institute, USA. Currently, her research focuses on investigating the role of macrophages in chronic transplant rejection.

作者簡介(中文翻譯)

馬爾戈札塔·克洛克博士：在加拿大完成博士後訓練之前，克洛克博士是波蘭華沙大學動物學系的終身副教授。她還曾擔任加拿大渥太華卡爾頓大學生物學系的研究助理。在完成博士後訓練期間，克洛克博士獲得了卡爾加里大學的AHFMR研究獎和達爾豪斯大學的MRC生物技術培訓獎。她於1987年加入德克薩斯大學MD安德森癌症中心，擔任分子遺傳學系的研究科學家，並於2006年成為生物化學與分子生物學系的副教授。克洛克博士於2008年加入休斯頓衛理公會研究所。目前，克洛克博士是休斯頓衛理公會醫院的韋爾康奈爾細胞與分子生物學教授，以及德克薩斯大學MD安德森癌症中心遺傳學系的兼任教授。

雅采克·Z·庫比亞克博士是法國雷恩法國國家研究院CNRS的研究主任（教授）。他的研究專注於早期胚胎發育的分子機制、細胞週期調控、幹細胞、癌細胞以及巨噬細胞在先天免疫反應中的作用。他是180多篇高被引科學文章的作者，並擔任10本書的編輯或共同編輯。他畢業於波蘭華沙大學，曾在美國威斯康辛大學麥迪遜分校、美國伍茲霍爾海洋生物實驗室和法國巴黎的雅克·莫諾研究所工作。他與波蘭華沙的WIM-PIB研究所合作，結合幹細胞、傷口癒合和癌症研究，並探索其在醫療應用中的前景。自COVID-19疫情爆發以來，他協調了一個專注於兒科患者SARS-CoV-2感染的國際研究小組，並持續跟進這一研究領域。

瑪塔·哈拉薩於2022年在波蘭盧布林醫科大學獲得醫學與健康科學博士學位。她在博士研究期間專注於表觀遺傳修飾因子，特別是組蛋白去乙醯酶，及其對癌症進展和轉移的影響。在攻讀博士學位期間，她在芬蘭土爾庫大學完成了一個長期實習，獲得了3D細胞技術的專業知識。她還在波蘭華沙的軍事醫學研究所進行了內部實習，研究阿茲海默症中的細胞基因治療。完成博士學位後，她在美國休斯頓衛理公會研究所獲得博士後研究員職位。目前，她的研究專注於調查巨噬細胞在慢性移植排斥中的作用。

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