Oxidative Stress in Cardiovascular-Metabolic Diseases
暫譯: 心血管代謝疾病中的氧化壓力
Eid, Ali Hussein, Kobeissy, Firas, El-Yazbi, Ahmed
- 出版商: Springer
- 出版日期: 2024-08-08
- 售價: $7,200
- 貴賓價: 9.5 折 $6,840
- 語言: 英文
- 頁數: 325
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 3031621301
- ISBN-13: 9783031621307
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相關分類:
化學 Chemistry
海外代購書籍(需單獨結帳)
商品描述
The book dissects the role of oxidative stress in the pathogenesis of the leading causes of global morbidity and mortality, i.e.cardiovascular and metabolic diseases. The chapters discuss topics related to the role reactive oxygen species (ROS) play in hypertension, atherosclerosis, diabetes, obesity and related pathologies. The authors also shed light on gender differences in the onset and pathologies of some of these diseases. Moreover, how ROS and aging interplay to precipitate cardiovasculo-metabolic disease is discussed and highlighted. Preventive measures that can abrogate ROS-induced cardiovasclo-metabolic disease are discussed and clarified in the hope of reducing such a debilitating battery of diseases. A section dedicated to antioxidants as potential therapy is also included. Furthermore, given the complexity of the mechanisms implicated in ROS-modulated responses, it remains challenging to assert a conclusive argument and pre-determined regimen for incorporating antioxidants into conventional therapies. Nonetheless, results from some clinical trials appear promising, warranting the addition of a chapter dedicated to such human trials.
In all of the chapters, the molecular, cellular, genetic, and pharmacological mechanisms implicated are covered from an applied science perspective.
This is an ideal book for basic researchers in the biomedical field, graduate students in biological and biomedical fields, medical students, instructors in medical and graduate schools, and professionals working for pharmaceutical companies.
商品描述(中文翻譯)
本書剖析了氧化壓力在全球主要疾病（即心血管疾病和代謝疾病）發病機制中的角色。各章節討論了活性氧種（reactive oxygen species, ROS）在高血壓、動脈粥樣硬化、糖尿病、肥胖及相關病理中的作用。作者還闡明了這些疾病在發病及病理上性別差異的問題。此外，書中探討並強調了ROS與老化如何相互作用以促進心血管代謝疾病的發展。針對能夠減少ROS引起的心血管代謝疾病的預防措施進行了討論和說明，希望能減少這些令人衰弱的疾病。書中還包括了一個專門討論抗氧化劑作為潛在療法的部分。此外，考慮到涉及ROS調節反應的機制的複雜性，確定將抗氧化劑納入傳統療法的結論性論點和預定方案仍然具有挑戰性。然而，一些臨床試驗的結果似乎顯示出希望，因此增添了一章專門討論這些人類試驗的內容。
在所有章節中，從應用科學的角度涵蓋了涉及的分子、細胞、遺傳和藥理機制。
這是一本理想的書籍，適合生物醫學領域的基礎研究人員、生物及生物醫學領域的研究生、醫學生、醫學及研究生院的講師，以及在製藥公司工作的專業人士。
作者簡介
Dr. Ali Hussein Eid, PhD, is an Associate Professor of Pharmacology at Qatar University.
Firas H. Kobaissy received a Ph.D. in molecular Neuroscience from the University of Florida (Gainesville) under the direction of Dr. Kevin K. Wang and Dr. Mark S. Gold. Most of his research focused on brain injury due to mechanical insult or due to drug abuse neurotoxicity using rat model. Dr. Kobaissy utilizes the state of the art proteomics tools to investigate cell death mechanisms involved in different brain insults.
Ahmed F. El-Yazbi graduated from the Faculty of Pharmacy, Alexandria University, Egypt in June 2001 with top honors. He moved on to get his PhD degree from the Faculty of Medicine at the University of Alberta in Edmonton, Canada, which was awarded in 2007. After the conclusion of his PhD, Dr. El-Yazbi was awarded two fellowships from the Canadian Institutes for Health Research and Alberta Innovates-Health Solutions, during which he conducted a research program studying the regulation of cerebral blood flow at the Faculty of Medicine in the University of Calgary, Canada. He is also a licensed Clinical Pharmacist and a Board-Certified Pharmacotherapy Specialist with extensive experience in highly specialized pharmaceutical services. Dr. El-Yazbi has a very solid university-level teaching and research track record evident in over 15 years of experience teaching to pharmacy and medical students in Canadian, Egyptian, and Lebanese universities. He also has over nine years of experience as a clinical pharmacist. He has over 30 original research articles published in international peer-reviewed journals and serves as an independent reviewer for a number of scientific/professional journals and bodies. Dr. El-Yazbi's contributions are recognized by invitations to present, speak, and chair scientific sessions in multiple national, regional, and international venues. Ahmed's current research and teaching interests at University level focus on investigating the mechanisms of vascular dysfunction in early stages of metabolic disease together with the identification of possible targets for therapeutic intervention with these detrimental pathways, in addition to related Pharmacy Practice and Therapeutic issues.
作者簡介(中文翻譯)
阿里·侯賽因·艾德博士（Dr. Ali Hussein Eid, PhD）是卡塔爾大學的藥理學副教授。
費拉斯·H·科巴伊西（Firas H. Kobaissy）在佛羅里達大學（University of Florida, Gainesville）獲得分子神經科學博士學位，指導教授為凱文·K·王博士（Dr. Kevin K. Wang）和馬克·S·戈德博士（Dr. Mark S. Gold）。他的研究主要集中在使用大鼠模型研究由機械損傷或藥物濫用神經毒性引起的腦損傷。科巴伊西博士利用最先進的蛋白質組學工具來研究不同腦損傷中涉及的細胞死亡機制。
艾哈邁德·F·艾爾-雅茲比（Ahmed F. El-Yazbi）於2001年6月以優異成績畢業於埃及亞歷山大大學藥學院。隨後，他在加拿大埃德蒙頓的阿爾伯塔大學醫學院獲得博士學位，於2007年頒發。完成博士學位後，艾爾-雅茲比博士獲得了來自加拿大健康研究院（Canadian Institutes for Health Research）和阿爾伯塔創新健康解決方案（Alberta Innovates-Health Solutions）的兩項獎學金，在此期間，他在加拿大卡爾加里大學醫學院進行了一項研究計劃，研究腦血流的調節。他也是一名持牌臨床藥師和經董事會認證的藥物治療專家，擁有豐富的專業藥學服務經驗。艾爾-雅茲比博士在加拿大、埃及和黎巴嫩的多所大學擁有超過15年的大學教學和研究經驗，並且擔任臨床藥師超過九年。他在國際同行評審期刊上發表了超過30篇原創研究文章，並擔任多個科學/專業期刊和機構的獨立審稿人。艾爾-雅茲比博士的貢獻獲得了多個國家、地區和國際會議的邀請，擔任演講者和科學會議的主席。艾哈邁德目前在大學的研究和教學興趣集中在調查代謝疾病早期階段的血管功能障礙機制，以及識別這些有害途徑的治療干預可能目標，並涉及相關的藥學實踐和治療問題。
