Epigenetic Mechanisms in Breast Cancer Therapy and Resistance
暫譯: 乳癌治療與抗藥性的表觀遺傳機制
Bhatnagar, Sanchita
- 出版商: Springer
- 出版日期: 2025-11-26
- 售價: $8,120
- 貴賓價: 9.5 折 $7,714
- 語言: 英文
- 頁數: 106
- 裝訂: Quality Paper - also called trade paper
- ISBN: 3031666887
- ISBN-13: 9783031666889
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商品描述
Epigenetic mechanisms are essential for normal mammalian development and maintenance of gene expression patterns. Disruption of epigenetic processes can lead to altered transcriptional regulation, gene levels, and malignant cellular transformation. Global alterations of the epigenetic landscape are a hallmark of tumorigenesis and metastasis. Conventionally, cancer was thought to be a genetic disease, but recent advancement in the field identified an abundance of epigenetic abnormalities along with genetic alterations. The extensive reprogramming of epigenetic machinery in cancer includes DNA methylation, histone modifications, nucleosome positioning and non-coding RNAs, specifically microRNA expression. Additionally, the reversible nature of epigenetic aberrations has led to the emergence of the promising field of epigenetic therapy, and recent FDA approval of epigenetic drugs for cancer treatment.
This book focuses on the epigenetic mechanisms in breast cancertherapy and resistance. It is organized into three sections, including epigenetic mechanisms in breast cancer, targeting epigenetic mechanisms for new therapies, and new and emerging methodologies to study epigenetic alterations in breast cancer. Chapters highlight various epigenetic regulations that prevent breast cancer growth and progression, as well as epigenetic alterations that contribute to breast cancer progression. This text is a useful methodology book for researchers and students interested in epigenetics in breast cancer and the fundamentals of cancer biology.
商品描述(中文翻譯)
表觀遺傳機制對於正常的哺乳動物發育及基因表達模式的維持至關重要。表觀遺傳過程的中斷可能導致轉錄調控、基因水平的改變以及惡性細胞轉化。表觀遺傳景觀的全球性改變是腫瘤生成和轉移的特徵。傳統上，癌症被認為是一種遺傳疾病，但最近該領域的進展發現了大量的表觀遺傳異常與遺傳改變並存。癌症中表觀遺傳機制的廣泛重編程包括DNA甲基化、組蛋白修飾、核小體定位和非編碼RNA，特別是微小RNA的表達。此外，表觀遺傳異常的可逆性促成了表觀遺傳治療這一有前景的領域的出現，以及最近FDA對癌症治療的表觀遺傳藥物的批准。
本書專注於乳腺癌治療及抗藥性中的表觀遺傳機制。內容分為三個部分，包括乳腺癌中的表觀遺傳機制、針對表觀遺傳機制的新療法，以及研究乳腺癌中表觀遺傳改變的新興方法。各章節強調了防止乳腺癌生長和進展的各種表觀遺傳調控，以及促進乳腺癌進展的表觀遺傳改變。本書是一本對於對乳腺癌中的表觀遺傳學及癌症生物學基礎感興趣的研究人員和學生非常有用的方法論書籍。
作者簡介
Dr. Bhatnagar received her Ph.D. in Infectious diseases from the University of Notre Dame in 2007. She carried out her postdoctoral research with Dr. Michael R. Green at the University of Massachusetts Medical School in Worcester, MA. It was there that Dr. Bhatnagar began her work in understanding the epigenetic regulation of mammalian gene expression.
Dr. Bhatnagar began her independent research career at the University of Virginia School of Medicine in 2015, where she was an Associate Professor in Biochemistry and Molecular Genetics. Recently, Dr. Bhatnagar joined the Medical Microbiology and Immunology department at University of California Davis. Dr. Bhatnagar's research program focuses on (i) understanding epigenetic silencing mechanisms in the control of mammalian gene expression, (ii) investigate how these mechanisms are deployed during development, and (iii) identify critical steps that, when altered, disrupt normal function.
作者簡介(中文翻譯)
巴特納博士於2007年在聖母大學獲得傳染病的博士學位。她在麻薩諸塞州伍斯特的麻薩諸塞大學醫學院與邁克爾·R·格林博士進行了博士後研究。在那裡，巴特納博士開始了對哺乳動物基因表達的表觀遺傳調控的研究。
巴特納博士於2015年在維吉尼亞大學醫學院開始她的獨立研究生涯，擔任生物化學與分子遺傳學的副教授。最近，巴特納博士加入了加州大學戴維斯分校的醫學微生物學與免疫學系。巴特納博士的研究計劃專注於（i）理解在控制哺乳動物基因表達中的表觀遺傳沉默機制，（ii）研究這些機制在發育過程中如何被運用，以及（iii）識別當改變時會破壞正常功能的關鍵步驟。
